Rome2Rio

How to get fromTupelo to Middlesboroby car, plane or bus

Find Transport to Middlesboro

See all options

There are 5 ways to get from Tupelo to Middlesboro by car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Golden Triangle Regional Airport, fly to Mcghee Tyson Airport, drive

    best
    1. Drive from Tupelo to Golden Triangle Regional Airport (GTR)car
    2. Fly from Golden Triangle Regional Airport (GTR) to Mcghee Tyson Airport (TYS)planeGTR - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Middlesborocar
    6h 6m
    $114–586

  2. Drive 405.9 mi

    cheapest
    1. Drive from Tupelo to Middlesborocar405.9 mi
    7h 44m
    $75–107

  3. Bus, drive (Greyhound)

    1. Take the bus from Tupelo to Atlanta Bus Stationbus
    2. Take the bus from Atlanta Bus Station to Londonbus
    3. Drive from London to Middlesborocar
    14h
    $109–236

  4. Drive to Golden Triangle Regional Airport, fly to Tri-Cities Regional Tn/Va Airport, drive

    1. Drive from Tupelo to Golden Triangle Regional Airport (GTR)car
    2. Fly from Golden Triangle Regional Airport (GTR) to Tri-Cities Regional Tn/Va Airport (TRI)planeGTR - TRI
    3. Drive from Tri-Cities-Regional-Airport-TRI to Middlesborocar
    6h 43m
    $83–382

  5. Fly Tupelo Regional Airport to Mcghee Tyson Airport, drive

    1. Fly from Tupelo Regional Airport (TUP) to Mcghee Tyson Airport (TYS)planeTUP - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Middlesborocar
    5h 51m
    $159–639

Golden Triangle Regional Airport (GTR) to Mcghee Tyson Airport (TYS) flights

Calendar17Weekly Planes
Duration4h 12mAverage Duration
Ticket$90Cheapest Price
See schedules

Questions & Answers

What companies run services between Tupelo, MS, USA and Middlesboro, KY, USA?

There is no direct connection from Tupelo to Middlesboro. However, you can drive to Golden Triangle Regional Airport (GTR) airport, fly to Mcghee Tyson Airport (TYS), then drive to Middlesboro. Alternatively, you can take a vehicle from Tupelo to Middlesboro via Tupelo, Atlanta Bus Station, and London in around 14h.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Trips from Tupelo

Trips to Middlesboro

Popular routes