What is the cheapest way to get from Tupelo to Middlesboro?

The cheapest way to get from Tupelo to Middlesboro is to drive which costs $70 - $110 and takes 7h 47m.

What is the fastest way to get from Tupelo to Middlesboro?

The fastest way to get from Tupelo to Middlesboro is to fly and drive which takes 4h 52m and costs $160 - $900.

How far is it from Tupelo to Middlesboro?

The distance between Tupelo and Middlesboro is 446 miles. The road distance is 408.2 miles.

How long does it take to get from Tupelo to Middlesboro?

It takes approximately 6h 13m to get from Tupelo to Middlesboro, including transfers.

What is the time difference between Tupelo and Middlesboro?

Middlesboro is 1h ahead of Tupelo. It is currently 3:23 PM in Tupelo and 4:23 PM in Middlesboro.

Can I drive from Tupelo to Middlesboro?

Yes, the driving distance between Tupelo to Middlesboro is 408 miles. It takes approximately 7h 47m to drive from Tupelo to Middlesboro.

Where can I stay near Middlesboro?

There are 20+ hotels available in Middlesboro.

Tupelo to Middlesboro - 5 ways to travel via car, plane, and bus

There are 5 ways to get from Tupelo to Middlesboro by car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Drive to Golden Triangle Regional Airport, fly, drive
best
1. Drive from Tupelo to Golden Triangle Regional Airport (GTR)car
2. Fly from Golden Triangle Regional Airport (GTR) to Mcghee Tyson Airport (TYS)plane GTR - TYS
3. Drive from Mcghee Tyson Airport (TYS) to Middlesborocar
6h 13m
$144–836
Drive 405.8 mi
cheapest
1. Drive from Tupelo to Middlesborocar 405.8 mi
7h 47m
$75–107
Bus, drive (Greyhound)
1. Take the bus from Tupelo to Atlanta Bus Stationbus
2. Take the bus from Atlanta Bus Station to Londonbus
3. Drive from London to Middlesborocar
14h 25m
$110–178
Bus to Memphis, fly, drive
1. Take the bus from Tupelo to Memphis Bus Stationbus
2. Fly from Memphis (MEM) to Mcghee Tyson Airport (TYS)plane MEM - TYS
3. Drive from Mcghee Tyson Airport (TYS) to Middlesborocar
6h 59m
$181–961
Fly from Tupelo Regional Airport, drive
1. Fly from Tupelo Regional Airport (TUP) to Mcghee Tyson Airport (TYS)plane TUP - TYS
2. Drive from Mcghee Tyson Airport (TYS) to Middlesborocar
4h 52m
$168–887

Golden Triangle Regional Airport (GTR) to Mcghee Tyson Airport (TYS) flights

12Weekly Planes

4h 29mAverage Duration

$122Cheapest Price

See schedules

Comparing Your Travel Options

Map of how to get from Tupelo to Middlesboro.

Launch map view

Distance: 443.1 mi
Duration: 6h 13m

What companies run services between Tupelo, MS, USA and Middlesboro, KY, USA?

There is no direct connection from Tupelo to Middlesboro. However, you can drive to Golden Triangle Regional Airport (GTR) airport, fly to Mcghee Tyson Airport (TYS), then drive to Middlesboro. Alternatively, you can take a vehicle from Tupelo to Middlesboro via Tupelo, Atlanta Bus Station, and London in around 14h 25m.

Airlines

Bus operators

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How to get fromTupelo to Middlesboroby car, plane, or bus

There are 5 ways to get from Tupelo to Middlesboro by car, plane, or bus

Drive to Golden Triangle Regional Airport, fly, drive

Drive 405.8 mi

Bus, drive (Greyhound)

Bus to Memphis, fly, drive

Fly from Tupelo Regional Airport, drive