There are 10 ways to get from Philadelphia to Middlesboro by plane, car, bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Philadelphia International Airport to Mcghee Tyson Airport, drive
best- Fly from Philadelphia International Airport (PHL) to Mcghee Tyson Airport (TYS)plane PHL - TYS
- Drive from Mcghee Tyson Airport (TYS) to Middlesborocar
5h 9m$186–1,023Fly Philadelphia International Airport to Blue Grass Airport, drive
cheapest- Fly from Philadelphia International Airport (PHL) to Blue Grass Airport (LEX)plane PHL - LEX
- Drive from Lexington-Airport-LEX to Middlesborocar
6h 1m$106–518Bus, drive
- Take the bus from Philadelphia Bus Station to New York City Chinatownbus
- Take the bus from New York, NY to Knoxville, TNbus Ny
- Drive from Knoxville, TN to Middlesborocar
17h 3m$127–160Drive 596.4 mi
- Drive from Philadelphia to Middlesborocar 596.4 mi
10h 59m$109–158Fly Philadelphia International Airport to Asheville Regional Airport, drive
- Fly from Philadelphia International Airport (PHL) to Asheville Regional Airport (AVL)plane PHL - AVL
- Drive from Asheville-Airport-AVL to Middlesborocar
6h 19m$108–523Train to Baltimore-Washington International Airport, fly to Mcghee Tyson Airport, drive
- Take the train from 30th Street Station to BWI Thurgood Marshalltrain
- Fly from Baltimore-Washington International Airport (BWI) to Mcghee Tyson Airport (TYS)plane BWI - TYS
- Drive from Mcghee Tyson Airport (TYS) to Middlesborocar
5h 56m$167–1,428Train to Laguardia Airport, fly to Mcghee Tyson Airport, drive
- Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain
- Fly from Laguardia Airport (LGA) to Mcghee Tyson Airport (TYS)plane LGA - TYS
- Drive from Mcghee Tyson Airport (TYS) to Middlesborocar
7h 25m$222–1,633Fly Philadelphia International Airport to Greenville–Spartanburg International Airport, drive
- Fly from Philadelphia International Airport (PHL) to Greenville–Spartanburg International Airport (GSP)plane PHL - GSP
- Drive from Greenville–Spartanburg International Airport (GSP) to Middlesborocar
7h 20m$158–808Bus, drive via Farragut
- Take the bus from Philadelphia Bus Station to New York Midtownbus
- Take the bus from New York to Knoxvillebus Nyc
- Drive from Knoxville to Middlesborocar
17h 6m$132–196Bus, drive via Dayton (Greyhound)
- Take the bus from Philadelphia Bus Station to Dayton Trotwood Bus Stationbus
- Take the bus from Dayton Trotwood Bus Station to Londonbus
- Drive from London to Middlesborocar
20h 31m$119–222
Philadelphia International Airport (PHL) to Mcghee Tyson Airport (TYS) flights
Questions & Answers
The cheapest way to get from Philadelphia to Middlesboro is to drive which costs $100 - $160 and takes 10h 59m.
The fastest way to get from Philadelphia to Middlesboro is to fly and drive which takes 5h 9m and costs $180 - $1,100.
The distance between Philadelphia and Middlesboro is 639 miles. The road distance is 599.9 miles.
It takes approximately 5h 9m to get from Philadelphia to Middlesboro, including transfers.
Yes, the driving distance between Philadelphia to Middlesboro is 600 miles. It takes approximately 10h 59m to drive from Philadelphia to Middlesboro.
There are 20+ hotels available in Middlesboro.
What companies run services between Philadelphia, PA, USA and Middlesboro, KY, USA?
There is no direct connection from Philadelphia to Middlesboro. However, you can take the train to Airport Terminal A, walk to Philadelphia International Airport (PHL) airport, fly to Mcghee Tyson Airport (TYS), then drive to Middlesboro. Alternatively, you can take a bus from Philadelphia Bus Station to Middlesboro via New York, NY and Knoxville, TN in around 17h 3m.
- Website
- aa.com
Flights from Philadelphia International Airport to Mcghee Tyson Airport
- Ave. Duration
- 2h 8m
- When
- Every day
- Estimated price
- $170–1,000
Flights from Philadelphia International Airport to Mcghee Tyson Airport via Charlotte
- Ave. Duration
- 4h 11m
- When
- Every day
- Estimated price
- $180–1,100
Flights from Philadelphia International Airport to Blue Grass Airport
- Ave. Duration
- 1h 50m
- When
- Every day
- Estimated price
- $80–480
Flights from Philadelphia International Airport to Blue Grass Airport via Charlotte
- Ave. Duration
- 4h 13m
- When
- Every day
- Estimated price
- $100–550
Flights from Philadelphia International Airport to Asheville Regional Airport
- Ave. Duration
- 1h 59m
- When
- Every day
- Estimated price
- $80–480
Flights from Philadelphia International Airport to Asheville Regional Airport via Charlotte
- Ave. Duration
- 4h 22m
- When
- Every day
- Estimated price
- $85–490
Flights from Baltimore-Washington International Airport to Mcghee Tyson Airport via Charlotte
- Ave. Duration
- 3h 48m
- When
- Every day
- Estimated price
- $140–850
Flights from Laguardia Airport to Mcghee Tyson Airport
- Ave. Duration
- 2h 17m
- When
- Every day
- Estimated price
- $180–1,000
Flights from Laguardia Airport to Mcghee Tyson Airport via Reagan Washington
- Ave. Duration
- 4h 13m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $180–1,000
Flights from Laguardia Airport to Mcghee Tyson Airport via Charlotte
- Ave. Duration
- 4h 18m
- When
- Every day
- Estimated price
- $190–1,100
Flights from Philadelphia International Airport to Greenville–Spartanburg International Airport
- Ave. Duration
- 1h 56m
- When
- Monday to Friday
- Estimated price
- $120–750
Flights from Philadelphia International Airport to Greenville–Spartanburg International Airport via Charlotte
- Ave. Duration
- 4h 3m
- When
- Monday to Tuesday
- Estimated price
- $120–750
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from 30th Street Station to BWI Thurgood Marshall
- Ave. Duration
- 1h 25m
- Frequency
- Hourly
- Estimated price
- $28–65
- Website
- Amtrak
Train from 30th Street Station to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 1h 24m
- Frequency
- Every 30 minutes
- Estimated price
- $24–55
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Philadelphia Bus Station to New York City Chinatown
- Ave. Duration
- 2h 30m
- Frequency
- Twice daily
- Estimated price
- $19–35
- Schedules at
- Flixbus USA
Bus from Philadelphia Bus Station to New York Midtown
- Ave. Duration
- 2h 10m
- Frequency
- Hourly
- Estimated price
- $20–35
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide







