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How to get fromPittsburgh to Middlesboroby bus, car or plane

Find Transport to Middlesboro

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There are 7 ways to get from Pittsburgh to Middlesboro by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, drive via Columbus

    best
    1. Take the bus from Pittsburgh Intermodal Station to Columbus Bus Stationbus
    2. Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Cincinnati, OHbus
    3. Take the bus from Cincinnati Bus Station to Londonbus
    4. Drive from London to Middlesborocar
    11h 46m
    $92–217

  2. Fly to Tri-Cities Regional Tn/Va Airport, drive

    cheapest
    1. Fly from Pittsburgh International Airport (PIT) to Tri-Cities Regional Tn/Va Airport (TRI)planePIT - TRI
    2. Drive from Tri-Cities-Regional-Airport-TRI to Middlesborocar
    8h 11m
    $82–404

  3. Drive 451.8 mi

    1. Drive from Pittsburgh to Middlesborocar451.8 mi
    8h 29m
    $83–120

  4. Fly to Mcghee Tyson Airport, drive

    1. Fly from Pittsburgh International Airport (PIT) to Mcghee Tyson Airport (TYS)planePIT - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Middlesborocar
    7h 49m
    $131–687

  5. Bus, drive (Greyhound)

    1. Take the bus from Pittsburgh Intermodal Station to Dayton Trotwood Bus Stationbus
    2. Take the bus from Dayton Trotwood Bus Station to Londonbus
    3. Drive from London to Middlesborocar
    13h 31m
    $99–192

  6. Bus, drive #2

    1. Take the bus from Pittsburgh Intermodal Station to Columbusbus
    2. Take the bus from Columbus to Dayton Trotwood Bus Stationbus
    3. Take the bus from Dayton Trotwood Bus Station to Londonbus
    4. Drive from London to Middlesborocar
    13h 41m
    $91–229

  7. Fly to Greenville–Spartanburg International Airport, drive

    1. Fly from Pittsburgh International Airport (PIT) to Greenville–Spartanburg International Airport (GSP)planePIT - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Middlesborocar
    7h 55m
    $195–499

Pittsburgh International Airport (PIT) to Mcghee Tyson Airport (TYS) flights

Calendar116Weekly Planes
Duration4h 34mAverage Duration
Ticket$118Cheapest Price
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Questions & Answers

What companies run services between Pittsburgh, PA, USA and Middlesboro, KY, USA?

There is no direct connection from Pittsburgh to Middlesboro. However, you can take the bus to Columbus Bus Station, take the bus to Cincinnati, OH, walk to Cincinnati Bus Station, take the bus to London, then drive to Middlesboro. Alternatively, you can drive from Pittsburgh to Middlesboro in around 8h 29m.

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