Rome2Rio

How to get fromPittsburgh to Middlesboroby bus, car or plane

Find Transport to Middlesboro

See all options

There are 7 ways to get from Pittsburgh to Middlesboro by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, drive via Columbus

    best
    1. Take the bus from Pittsburgh Intermodal Station to Columbus Bus Stationbus
    2. Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Cincinnati, OHbus
    3. Take the bus from Cincinnati Bus Station to Londonbus
    4. Drive from London to Middlesborocar
    11h 46m
    $92–217

  2. Fly to Tri-Cities Regional Tn/Va Airport, drive

    cheapest
    1. Fly from Pittsburgh International Airport (PIT) to Tri-Cities Regional Tn/Va Airport (TRI)planePIT - TRI
    2. Drive from Tri-Cities-Regional-Airport-TRI to Middlesborocar
    7h 58m
    $82–404

  3. Drive 451.8 mi

    1. Drive from Pittsburgh to Middlesborocar451.8 mi
    8h 29m
    $83–120

  4. Fly to Mcghee Tyson Airport, drive

    1. Fly from Pittsburgh International Airport (PIT) to Mcghee Tyson Airport (TYS)planePIT - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Middlesborocar
    7h 37m
    $131–687

  5. Bus, drive (Greyhound)

    1. Take the bus from Pittsburgh Intermodal Station to Dayton Trotwood Bus Stationbus
    2. Take the bus from Dayton Trotwood Bus Station to Londonbus
    3. Drive from London to Middlesborocar
    13h 31m
    $99–192

  6. Bus, drive #2

    1. Take the bus from Pittsburgh Intermodal Station to Columbusbus
    2. Take the bus from Columbus to Dayton Trotwood Bus Stationbus
    3. Take the bus from Dayton Trotwood Bus Station to Londonbus
    4. Drive from London to Middlesborocar
    13h 41m
    $91–229

  7. Fly to Greenville–Spartanburg International Airport, drive

    1. Fly from Pittsburgh International Airport (PIT) to Greenville–Spartanburg International Airport (GSP)planePIT - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Middlesborocar
    7h 42m
    $195–499

Pittsburgh International Airport (PIT) to Mcghee Tyson Airport (TYS) flights

Calendar116Weekly Planes
Duration4h 34mAverage Duration
Ticket$118Cheapest Price
See schedules

Questions & Answers

What companies run services between Pittsburgh, PA, USA and Middlesboro, KY, USA?

There is no direct connection from Pittsburgh to Middlesboro. However, you can take the bus to Columbus Bus Station, take the bus to Cincinnati, OH, walk to Cincinnati Bus Station, take the bus to London, then drive to Middlesboro. Alternatively, you can drive from Pittsburgh to Middlesboro in around 8h 29m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Trips from Pittsburgh

Trips to Middlesboro

Popular routes