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How to get fromIndianapolis to Middlesboroby bus, car or plane

Find Transport to Middlesboro

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There are 6 ways to get from Indianapolis to Middlesboro by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, drive

    best
    1. Take the bus from Indianapolis, IN to Greyhound Station Cincinnatibus bus
    2. Take the bus from Cincinnati Bus Station to Londonbus bus
    3. Drive from London to Middlesborocar car
    8h 41m
    $58–133

  2. Drive 301.9 mi

    cheapest
    1. Drive from Indianapolis to Middlesborocar car 301.9 mi
    5h 40m
    $56–80

  3. Fly Indianapolis to Mcghee Tyson Airport, drive

    1. Fly from Indianapolis (IND) to Mcghee Tyson Airport (TYS)plane plane IND - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Middlesborocar car
    7h 5m
    $145–822

  4. Bus, drive via Cincinnati

    1. Take the bus from Indianapolis to Cincinnatibus bus
    2. Take the bus from Cincinnati Bus Station to Londonbus bus
    3. Drive from London to Middlesborocar car
    9h 1m
    $60–197

  5. Fly Indianapolis to Tri-Cities Regional Tn/Va Airport, drive

    1. Fly from Indianapolis (IND) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane IND - TRI
    2. Drive from Tri-Cities-Regional-Airport-TRI to Middlesborocar car
    7h 31m
    $109–578

  6. Bus to Chicago O'Hare International Airport, fly to Mcghee Tyson Airport, drive

    1. Take the bus from Indianapolis to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Middlesborocar car
    8h 59m
    $148–681

Indianapolis (IND) to Mcghee Tyson Airport (TYS) flights

Calendar103Weekly Planes
Duration4h 37mAverage Duration
Ticket$138Cheapest Price
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Questions & Answers

What companies run services between Indianapolis, IN, USA and Middlesboro, KY, USA?

There is no direct connection from Indianapolis to Middlesboro. However, you can take the bus to Greyhound Station Cincinnati, walk to Cincinnati Bus Station, take the bus to London, then drive to Middlesboro. Alternatively, you can drive from Indianapolis to Middlesboro in around 5h 40m.

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Need to know: Greyhound

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