There are 9 ways to get from Charlotte to Middlesboro by plane, car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Mcghee Tyson Airport, drive
best- Fly from Charlotte Douglas International Airport (CLT) to Mcghee Tyson Airport (TYS)plane CLT - TYS
- Drive from Mcghee Tyson Airport (TYS) to Middlesborocar
4h 25m$90–622Drive 249.2 mi
cheapest- Drive from Charlotte to Middlesborocar 249.2 mi
4h 54m$46–66Bus, drive
- Take the bus from Charlotte Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Londonbus
- Drive from London to Middlesborocar
12h 36m$88–182Fly to Tri-Cities Regional Tn/Va Airport, drive
- Fly from Charlotte Douglas International Airport (CLT) to Tri-Cities Regional Tn/Va Airport (TRI)plane CLT - TRI
- Drive from Tri-Cities-Regional-Airport-TRI to Middlesborocar
4h 28m$64–408Fly to Asheville Regional Airport, drive
- Fly from Charlotte Douglas International Airport (CLT) to Asheville Regional Airport (AVL)plane CLT - AVL
- Drive from Asheville-Airport-AVL to Middlesborocar
5h 23m$57–302Fly to Blue Grass Airport, drive
- Fly from Charlotte Douglas International Airport (CLT) to Blue Grass Airport (LEX)plane CLT - LEX
- Drive from Lexington-Airport-LEX to Middlesborocar
5h 38m$65–327Fly to Chattanooga Metropolitan Airport, drive
- Fly from Charlotte Douglas International Airport (CLT) to Chattanooga Metropolitan Airport (CHA)plane CLT - CHA
- Drive from Chattanooga Metropolitan Airport (CHA) to Middlesborocar
5h 55m$66–327Fly to Greenville–Spartanburg International Airport, drive
- Fly from Charlotte Douglas International Airport (CLT) to Greenville–Spartanburg International Airport (GSP)plane CLT - GSP
- Drive from Greenville–Spartanburg International Airport (GSP) to Middlesborocar
6h 22m$277–607Bus, drive via Sandy Springs
- Take the bus from Charlotte to Atlantabus
- Take the bus from Atlanta Bus Station to Londonbus
- Drive from London to Middlesborocar
16h 17m$127–287
Charlotte Douglas International Airport (CLT) to Mcghee Tyson Airport (TYS) flights
Questions & Answers
The cheapest way to get from Charlotte to Middlesboro is to drive which costs $45 - $70 and takes 4h 54m.
The fastest way to get from Charlotte to Middlesboro is to fly and drive which takes 4h 25m and costs $90 - $650.
The distance between Charlotte and Middlesboro is 259 miles. The road distance is 250.6 miles.
It takes approximately 4h 25m to get from Charlotte to Middlesboro, including transfers.
Yes, the driving distance between Charlotte to Middlesboro is 251 miles. It takes approximately 4h 54m to drive from Charlotte to Middlesboro.
There are 25+ hotels available in Middlesboro.
What companies run services between Charlotte, NC, USA and Middlesboro, KY, USA?
There is no direct connection from Charlotte to Middlesboro. However, you can take the line 5 bus to Charlotte Douglas Airport, walk to Charlotte Douglas International Airport (CLT) airport, fly to Mcghee Tyson Airport (TYS), then drive to Middlesboro. Alternatively, you can take a bus from Charlotte Bus Station to Middlesboro via Atlanta Bus Station and London in around 12h 36m.
- Website
- aa.com
Flights from Charlotte Douglas International Airport to Mcghee Tyson Airport
- Ave. Duration
- 1h 21m
- When
- Every day
- Estimated price
- $75–600
Flights from Charlotte Douglas International Airport to Tri-Cities Regional Tn/Va Airport
- Ave. Duration
- 1h 13m
- When
- Every day
- Estimated price
- $45–380
Flights from Charlotte Douglas International Airport to Asheville Regional Airport
- Ave. Duration
- 1h 2m
- When
- Every day
- Estimated price
- $30–260
Flights from Charlotte Douglas International Airport to Blue Grass Airport
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $40–290
Flights from Charlotte Douglas International Airport to Chattanooga Metropolitan Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- $35–280
Flights from Charlotte Douglas International Airport to Greenville–Spartanburg International Airport
- Ave. Duration
- 57 min
- When
- Every day
- Estimated price
- $35–330
- Website
- delta.com
Flights from Charlotte Douglas International Airport to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 3h 29m
- When
- Monday, Tuesday, Wednesday, and Saturday
- Estimated price
- $100–700
Flights from Charlotte Douglas International Airport to Blue Grass Airport via Atlanta
- Ave. Duration
- 3h 48m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $55–330
Flights from Charlotte Douglas International Airport to Chattanooga Metropolitan Airport via Atlanta
- Ave. Duration
- 3h 22m
- When
- Every day
- Estimated price
- $40–300
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Charlotte Bus Station to Atlanta Bus Station
- Ave. Duration
- 4h 10m
- Frequency
- 4 times a day
- Estimated price
- $28–50
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Charlotte Bus Station to Atlanta Bus Station
- Ave. Duration
- 4h 40m
- Frequency
- 5 times a day
- Estimated price
- $40–75
- Website
- https://www.greyhound.com/
Bus from Atlanta Bus Station to London
- Ave. Duration
- 6h 5m
- Frequency
- Once daily
- Estimated price
- $50–95
- Website
- https://www.greyhound.com/
- Phone
- +1 888 358 6762
- info@tornadobus.com
- Website
- tornadobus.com
Bus from Charlotte to Atlanta
- Ave. Duration
- 5h 50m
- Frequency
- Once daily
- Estimated price
- $60–170
- Schedules at
- tornadobus.com
- Adults 11-59
- $60–170
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide





