The average train between Tuscany and Isernia takes 6h 4m and the fastest train takes 3h 55m. The train service runs several times per day from Tuscany to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Tuscany and Isernia. The earliest departure is at 10:43 AM in the morning, and the last departure from Tuscany is at 8:28 PM which arrives into Isernia at 8:27 AM. All services require a transfer, and take on average 6h 4m. The schedules shown below are for the next available departures.

4h 40m • 1 change

4h 12m • 1 change

4h 23m • 1 change
Arrives next day

11h 59m • 1 change

4h 40m • 1 change

4h 12m • 1 change

4h 23m • 1 change
Arrives next day

11h 59m • 1 change

4h 12m • 1 change

4h 27m • 1 change

3h 55m • 1 change
Arrives next day

11h 59m • 1 change

4h 40m • 1 change

4h 12m • 1 change

4h 23m • 1 change
Arrives next day

11h 59m • 1 change
Want to know about travelling from Tuscany to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Tuscany to Isernia. However, there are services departing from Tuscany station and arriving at Isernia station via Roma Termini. The journey, including transfers, takes approximately 6h 4m.
Tuscany to Isernia train services, operated by ItaloTreno, depart from Firenze Santa Maria Novella station.
Tuscany to Isernia train services, operated by ItaloTreno, arrive at Isernia station.
Book your Tuscany to Isernia train tickets online with ItaloTreno and Trenitalia.
The distance between Tuscany and Isernia is 327.4 km. The road distance is 447 km.
You can take a train from Firenze Santa Maria Novella to Isernia via Roma Termini in around 4h 44m.