Tuscany to Isernia Trains

Tuscany to Isernia trains

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Trip Overview

The average train between Tuscany and Isernia takes 5h 50m and the fastest train takes 4h 24m. The train service runs several times per day from Tuscany to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 50m
Duration: 447 km
Distance: €66
Average price: 5 times a day
Frequency

Train (Trenitalia)

best

Take the train from Firenze S.M.N. to Roma Terminitrain Fr
Take the train from Roma Termini to Iserniatrain Re

€51–115

Tuscany to Isernia train times

Trains run 5 times a day between Tuscany and Isernia. The earliest departure is at 6:00 AM in the morning, and the last departure from Tuscany is at 10:14 PM which arrives into Isernia at 8:27 AM. All services require a transfer, and take on average 5h 50m. The schedules shown below are for the next available departures.

Departing Saturday, August 22, 2026

10:14 PM → 8:27 AM
Arrives next day
10h 13m • 1 change

Departing Sunday, August 23, 2026

12:14 PM → 4:40 PM
4h 26m • 1 change
3:14 PM → 7:55 PM
4h 41m • 1 change
5:59 PM → 10:23 PM
4h 24m • 1 change
10:14 PM → 8:27 AM
Arrives next day
10h 13m • 1 change

Departing Monday, August 24, 2026

6:00 AM → 11:15 AM
5h 15m • 1 change
10:59 AM → 3:23 PM
4h 24m • 1 change
12:14 PM → 4:40 PM
4h 26m • 1 change
5:48 PM → 10:26 PM
4h 38m • 1 change
Show more

Departing Tuesday, August 25, 2026

6:00 AM → 11:15 AM
5h 15m • 1 change
10:59 AM → 3:23 PM
4h 24m • 1 change
12:14 PM → 4:40 PM
4h 26m • 1 change
5:48 PM → 10:26 PM
4h 38m • 1 change
Show more

Departing Wednesday, August 26, 2026

6:00 AM → 11:15 AM
5h 15m • 1 change
10:59 AM → 3:23 PM
4h 24m • 1 change
12:14 PM → 4:40 PM
4h 26m • 1 change
5:48 PM → 10:26 PM
4h 38m • 1 change
Show more

Departing Thursday, August 27, 2026

6:00 AM → 11:15 AM
5h 15m • 1 change
10:59 AM → 3:23 PM
4h 24m • 1 change
12:14 PM → 4:40 PM
4h 26m • 1 change
5:48 PM → 10:26 PM
4h 38m • 1 change
Show more

Departing Friday, August 28, 2026

6:00 AM → 11:15 AM
5h 15m • 1 change
10:59 AM → 3:23 PM
4h 24m • 1 change
12:14 PM → 4:40 PM
4h 26m • 1 change
5:48 PM → 10:26 PM
4h 38m • 1 change

Frequently asked questions

Want to know about travelling from Tuscany to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.