There are 5 ways to get from Tuscany to Isernia by train (Trenitalia), bus, car, plane, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train
best- Take the train from Florence Santa Maria Novella to Roma Terminitrain 8959 / ...
- Take the train from Roma Termini to Iserniatrain Re
4h 40m€34–67Bus via Rome
cheapest- Take the bus from Florence to Roma, Autostazione Tiburtinabus N520 / ...
- Take the bus from Roma, Autostazione Tiburtina to Iserniabus Rome Tiburtina
6h 35m€15–41Drive 428.2 km
- Drive from Florence to Iserniacar 428.2 km
4h 6m€66–96Fly, train
- Fly from Florence Peretola Airport (FLR) to Fiumicino International Airport (FCO)plane FLR - FCO
- Take the train from Roma Termini to Iserniatrain
6h 3m€76–217Bus
- Take the bus from Florence Villa Constanza Bus Station to Caianellobus
- Take the bus from Casello - A1 Ingresso Caianello to Iserniabus 6
8h 53m€34–55
Tuscany to Isernia by train
Questions & Answers
The cheapest way to get from Tuscany to Isernia is to bus via Rome which costs €15 - €45 and takes 6h 35m.
The fastest way to get from Tuscany to Isernia is to drive which takes 4h 6m and costs €65 - €95.
No, there is no direct bus from Tuscany to Isernia. However, there are services departing from Florence and arriving at Isernia via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 6h 35m.
No, there is no direct train from Tuscany to Isernia. However, there are services departing from Florence Santa Maria Novella and arriving at Isernia via Roma Termini. The journey, including transfers, takes approximately 4h 40m.
The distance between Tuscany and Isernia is 447 km. The road distance is 428.2 km.
The best way to get from Tuscany to Isernia without a car is to train which takes 4h 40m and costs €30 - €70.
It takes approximately 4h 40m to get from Tuscany to Isernia, including transfers.
Tuscany to Isernia bus services, operated by FlixBus, depart from Florence station.
Tuscany to Isernia train services, operated by ItaloTreno, depart from Florence Santa Maria Novella station.
The best way to get from Tuscany to Isernia is to train which takes 4h 40m and costs €30 - €70. Alternatively, you can bus via Rome, which costs €15 - €45 and takes 6h 35m.
What companies run services between Tuscany, Italy and Isernia, Italy?
You can take a train from Florence Santa Maria Novella to Isernia via Roma Termini in around 4h 40m. Alternatively, you can take a bus from Florence to Isernia via Roma, Autostazione Tiburtina in around 6h 35m.
- Website
- ita-airways.com
Flights from Florence Peretola Airport to Fiumicino International Airport
- Ave. Duration
- 55 min
- When
- Every day
- Estimated price
- €55–160
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Florence Santa Maria Novella to Roma Termini
- Ave. Duration
- 1h 32m
- Frequency
- Hourly
- Estimated price
- €22–50
- Website
- https://www.italotreno.it/en
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €11–17
- Website
- https://www.trenitalia.com/en.html
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Florence to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 25m
- Frequency
- 3 times a day
- Estimated price
- €7–16
- Website
- https://www.flixbus.co.uk
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- €8–22
- Website
- https://www.flixbus.co.uk
- Phone
- +39081/969167
- servizioclienti@leonettiroma.it
- Website
- leonettiroma.it
Bus from Florence to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h
- Frequency
- Once a week
- Estimated price
- €14–20
- Website
- https://www.leonettiroma.it/
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
- Phone
- +39 0827 34 117
- info@gruppodimaio.it
- Website
- gruppodimaio.it
Bus from Florence Villa Constanza Bus Station to Caianello
- Ave. Duration
- 5h 20m
- Frequency
- Twice a week
- Estimated price
- €30–50
- Schedules at
- gruppodimaio.it
- Phone
- 0865.221788
- info@satiautobus.com
- Website
- satiautobus.com
Bus from Casello - A1 Ingresso Caianello to Isernia
- Ave. Duration
- 55 min
- Frequency
- 3 times a day
- Estimated price
- €2–3
- Schedules at
- satiautobus.com
Want to know more about travelling around Italy
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More Questions & Answers
Tuscany to Isernia bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Tuscany to Isernia train services, operated by ItaloTreno, arrive at Roma Termini station.
Yes, the driving distance between Tuscany to Isernia is 428 km. It takes approximately 4h 6m to drive from Tuscany to Isernia.
Book your Tuscany to Isernia bus tickets online with Omio and FlixBus.
There are 357+ hotels available in Isernia.

























