The average train between Ancona and Isernia takes 8h 42m and the fastest train takes 6h 18m. The train service runs several times per day from Ancona to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Ancona and Isernia. The earliest departure is at 3:33 AM at night, and the last departure from Ancona is at 7:50 PM which arrives into Isernia at 8:27 AM. All services require a transfer, and take on average 8h 42m. The schedules shown below are for the next available departures.

6h 18m • 1 change

8h 36m • 1 change
Arrives next day

12h 37m • 1 change

7h 42m • 1 change

6h 18m • 1 change

8h 36m • 1 change
Arrives next day

12h 37m • 1 change

7h 42m • 1 change

7h 35m • 1 change

8h 33m • 1 change
Arrives next day

12h 37m • 1 change

7h 42m • 1 change

6h 18m • 1 change

8h 36m • 1 change
Arrives next day

12h 37m • 1 change

7h 42m • 1 change

6h 18m • 1 change

8h 36m • 1 change
Arrives next day

12h 37m • 1 change
Want to know about travelling from Ancona to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Ancona to Isernia. However, there are services departing from Ancona station and arriving at Isernia station via Roma Termini. The journey, including transfers, takes approximately 8h 42m.
Ancona to Isernia train services, operated by Trenitalia, depart from Ancona station.
Ancona to Isernia train services, operated by Trenitalia, arrive at Isernia station.
Book your Ancona to Isernia train tickets online with Trenitalia.
The distance between Ancona and Isernia is 230.1 km. The road distance is 463 km.
You can take a train from Ancona to Isernia via Roma Termini in around 6h 54m.