The average train between Manfredonia and Isernia takes 8h 9m and the fastest train takes 5h 32m. The train service runs several times per day from Manfredonia to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Manfredonia and Isernia. The earliest departure is at 7:38 AM in the morning, and the last departure from Manfredonia is at 6:42 PM which arrives into Isernia at 9:21 AM. All services require a transfer at Foggia and take an average of 8h 9m. The schedules shown below are for the next available departures.


6h 26m • 2 changes


5h 32m • 2 changes
Arrives next day


14h 39m • 2 changes


6h 26m • 2 changes


5h 32m • 2 changes
Arrives next day


14h 39m • 2 changes


6h 26m • 2 changes


5h 32m • 2 changes
Arrives next day


14h 39m • 2 changes


6h 26m • 2 changes


5h 32m • 2 changes
Arrives next day


14h 39m • 2 changes
Want to know about travelling from Manfredonia to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Manfredonia to Isernia. However, there are services departing from Manfredonia station and arriving at Isernia station via Caserta. The journey, including transfers, takes approximately 8h 9m.
Manfredonia to Isernia train services, operated by Trenitalia, depart from Foggia station.
Manfredonia to Isernia train services, operated by Trenitalia, arrive at Isernia station.
Book your Manfredonia to Isernia train tickets online with Trenitalia and Trenitalia Frecce.
The distance between Manfredonia and Isernia is 140.1 km. The road distance is 284 km.
You can take a train from Manfredonia to Isernia via Foggia and Caserta in around 5h 20m.