Train Lugano to Isernia from €161 | Tickets & Timetables

Trip Overview

The average train between Lugano and Isernia takes 9h 40m and the fastest train takes 7h 21m. The train service runs several times per day from Lugano to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

9h 40m
Duration: 823 km
Distance: €161
Average price: 5 times a day
Frequency

Train

best

Take the train from Lugano to Milano Centraletrain
Take the train from Milano Centrale to Roma Terminitrain Fr / ...
Take the train from Roma Termini to Iserniatrain Re

7h 51m

€121–279

Lugano to Isernia train times

Trains run 5 times a day between Lugano and Isernia. The earliest departure is at 8:02 AM in the morning, and the last departure from Lugano is at 9:02 PM which arrives into Isernia at 11:15 AM. All services require a transfer at Milano Centrale and take an average of 9h 40m. The schedules shown below are for the next available departures.

Departing Tuesday, May 19, 2026

8:02 AM → 3:23 PM
7h 21m • 2 changes
9:02 AM → 4:40 PM
7h 38m • 2 changes
3:02 PM → 10:26 PM
7h 24m • 2 changes
7:02 PM → 8:27 AM
Arrives next day
13h 25m • 2 changes
Show more

Departing Wednesday, May 20, 2026

8:02 AM → 3:23 PM
7h 21m • 2 changes
9:02 AM → 4:40 PM
7h 38m • 2 changes
3:02 PM → 10:26 PM
7h 24m • 2 changes
7:02 PM → 8:27 AM
Arrives next day
13h 25m • 2 changes
Show more

Departing Thursday, May 21, 2026

8:02 AM → 3:23 PM
7h 21m • 2 changes
9:02 AM → 4:40 PM
7h 38m • 2 changes
3:02 PM → 10:26 PM
7h 24m • 2 changes
7:02 PM → 8:27 AM
Arrives next day
13h 25m • 2 changes
Show more

Departing Friday, May 22, 2026

8:02 AM → 3:23 PM
7h 21m • 2 changes
9:02 AM → 4:40 PM
7h 38m • 2 changes
3:02 PM → 10:26 PM
7h 24m • 2 changes
7:02 PM → 8:27 AM
Arrives next day
13h 25m • 2 changes

Departing Saturday, May 23, 2026

8:02 AM → 3:23 PM
7h 21m • 2 changes
9:02 AM → 4:40 PM
7h 38m • 2 changes
3:02 PM → 10:26 PM
7h 24m • 2 changes
6:02 PM → 8:27 AM
Arrives next day
14h 25m • 2 changes

Departing Sunday, May 24, 2026

9:02 AM → 4:40 PM
7h 38m • 2 changes
12:02 PM → 7:55 PM
7h 53m • 2 changes
3:02 PM → 10:23 PM
7h 21m • 2 changes
7:02 PM → 8:27 AM
Arrives next day
13h 25m • 2 changes
Show more

Departing Monday, May 25, 2026

8:02 AM → 3:23 PM
7h 21m • 2 changes
9:02 AM → 4:40 PM
7h 38m • 2 changes
3:02 PM → 10:26 PM
7h 24m • 2 changes

Frequently asked questions

Want to know about travelling from Lugano to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.