There are 4 ways to get from Tupelo to St. Louis by bus (Greyhound, Flixbus), car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Tupelo to Memphis Bus Stationbus Greyhound US0610
- Take the bus from Memphis Bus Station to St Louis Bus Stationbus Greyhound US1173
8h 9m$79–152Drive 368.8 mi
cheapest- Drive from Tupelo to St. Louiscar 368.8 mi
6h 31m$68–98Drive to Golden Triangle Regional Airport, fly
- Drive from Tupelo to Golden Triangle Regional Airport (GTR)car
- Fly from Golden Triangle Regional Airport (GTR) to Lambert–St. Louis International Airport (STL)plane GTR - STL
6h 13m$124–619Fly from Tupelo Regional Airport
- Fly from Tupelo Regional Airport (TUP) to Lambert–St. Louis International Airport (STL)plane TUP - STL
5h 41m$109–572
Golden Triangle Regional Airport (GTR) to Lambert–St. Louis International Airport (STL) flights
Questions & Answers
The cheapest way to get from Tupelo to St. Louis is to drive which costs $65 - $100 and takes 6h 31m.
The fastest way to get from Tupelo to St. Louis is to fly which takes 5h 41m and costs $100 - $600.
The distance between Tupelo and St. Louis is 398 miles. The road distance is 371 miles.
The best way to get from Tupelo to St. Louis without a car is to bus which takes 8h 9m and costs $75 - $160.
It takes approximately 8h 9m to get from Tupelo to St. Louis, including transfers.
The best way to get from Tupelo to St. Louis is to bus which takes 8h 9m and costs $75 - $160. Alternatively, you can fly, which costs $100 - $600 and takes 5h 41m.
Yes, the driving distance between Tupelo to St. Louis is 371 miles. It takes approximately 6h 31m to drive from Tupelo to St. Louis.
There are 445+ hotels available in St. Louis.
What companies run services between Tupelo, MS, USA and St. Louis, MO, USA?
You can take a vehicle from Tupelo to St Louis Bus Station via Tupelo and Memphis Bus Station in around 8h 9m. Alternatively, Corporate Flight Management Inc, Southwest Airlines, and American Airlines fly from Tupelo Regional Airport (TUP) to Lambert–St. Louis International Airport (STL) once daily.
- Website
- delta.com
Flights from Golden Triangle Regional Airport to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 5h 57m
- When
- Every day
- Estimated price
- $110–600
- Website
- aa.com
Flights from Golden Triangle Regional Airport to Lambert–St. Louis International Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 10m
- When
- Every day
- Estimated price
- $140–700
Flights from Tupelo Regional Airport to Lambert–St. Louis International Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 47m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $140–700
- Website
- southwest.com
Flights from Tupelo Regional Airport to Lambert–St. Louis International Airport via Nashville
- Ave. Duration
- 5h 40m
- When
- Monday and Sunday
- Estimated price
- $90–550
Flights from Tupelo Regional Airport to Lambert–St. Louis International Airport via Nashville, Chicago Midway
- Ave. Duration
- 7h 15m
- When
- Thursday and Friday
- Estimated price
- $120–650
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Tupelo to Memphis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Twice daily
- Estimated price
- $29–60
- Website
- https://www.greyhound.com/
Bus from Memphis Bus Station to St Louis Bus Station
- Ave. Duration
- 5h 15m
- Frequency
- Once daily
- Estimated price
- $40–65
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Memphis Bus Station to St Louis Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- 5 times a week
- Estimated price
- $45–80
- Schedules at
- flixbus.com
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