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How to get fromTupelo to St. LouisBy bus (Greyhound, Flixbus), car, plane, or bus

Find Transport to St. Louis

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There are 5 ways to get from Tupelo to St. Louis by bus (Greyhound, Flixbus), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Tupelo to Memphis Bus Stationbus bus Greyhound US0610
    2. Take the bus from Memphis Bus Station to St Louis Bus Stationbus bus FlixBus 2510
    7h 39m
    $62–139

  2. Drive 368.8 mi

    1. Drive from Tupelo to St. Louiscar car 368.8 mi
    6h 24m
    $68–98

  3. Drive to Golden Triangle Regional Airport, fly

    1. Drive from Tupelo to Golden Triangle Regional Airport (GTR)car car
    2. Fly from Golden Triangle Regional Airport (GTR) to Lambert–St. Louis International Airport (STL)plane plane GTR - STL
    7h 49m
    $144–719

  4. Fly from Tupelo Regional Airport

    1. Fly from Tupelo Regional Airport (TUP) to Lambert–St. Louis International Airport (STL)plane plane TUP - STL
    5h 56m
    $138–820

  5. Bus to Memphis, fly

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Fly from Memphis (MEM) to Lambert–St. Louis International Airport (STL)plane plane MEM - STL
    8h 34m
    $161–853

Golden Triangle Regional Airport (GTR) to Lambert–St. Louis International Airport (STL) flights

Calendar20Weekly Planes
Duration6h 35mAverage Duration
Ticket$130Cheapest Price
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Questions & Answers

What companies run services between Tupelo, MS, USA and St. Louis, MO, USA?

You can take a vehicle from Tupelo to St Louis Bus Station via Tupelo and Memphis Bus Station in around 7h 39m. Alternatively, Corporate Flight Management Inc, Southwest Airlines, and two other airlines fly from Tupelo Regional Airport (TUP) to Lambert–St. Louis International Airport (STL) twice daily.

Airlines
Bus operators

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