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How to get fromMobile to St. Louisby plane, train, bus, or car

Find Transport to St. Louis

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There are 6 ways to get from Mobile to St. Louis by plane, train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Mobile Regional Airport

    best
    1. Fly from Mobile Regional Airport (MOB) to Lambert–St. Louis International Airport (STL)plane plane MOB - STL
    5h
    $135–640

  2. Bus to Pensacola International Airport, fly

    cheapest
    1. Take the bus from Mobile Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Lambert–St. Louis International Airport (STL)plane plane PNS - STL
    5h 48m
    $97–498

  3. Train, bus

    1. Take the train from Mobile, AL to New Orleans, LA - Union Passenger Terminaltrain train Mobile / ...
    2. Take the bus from New Orleans Bus Station to St Louis Bus Stationbus bus Greyhound US1173
    19h 23m
    $140–257

  4. Train, bus via Carbondale

    1. Take the train from Mobile, AL to New Orleans, LA - Union Passenger Terminaltrain train
    2. Take the train from New Orleans Union Passenger Terminal to Carbondaletrain train
    3. Take the bus from Carbondale to St. Louisbus bus
    21h 11m
    $204–477

  5. Drive  642.5 mi

    1. Drive from Mobile to St. Louiscar car 642.5 mi
    11h 47m
    $118–170

  6. Bus to Destin–Fort Walton Beach Airport, fly

    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL)plane plane VPS - STL
    5h 48m
    $192–679

Mobile Regional Airport (MOB) to Lambert–St. Louis International Airport (STL) flights

Calendar83Weekly Planes
Duration5h 36mAverage Duration
Ticket$108Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mobile to St. Louis.ExpandLaunch map view
  • Distance: 596.9 mi
  • Duration: 5h

What companies run services between Mobile, AL, USA and St. Louis, MO, USA?

Delta, American Airlines, and United Airlines fly from Mobile Regional Airport (MOB) to Lambert–St. Louis International Airport (STL) every 2 hours.

Airlines
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Bus operators

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