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How to get fromMobile to St. Louisby bus, plane, bus (Flixbus), train, car or bus (Greyhound, Flixbus)

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There are 9 ways to get from Mobile to St. Louis by bus, plane, bus (Flixbus), train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Destin–Fort Walton Beach Airport, fly to Lambert–St. Louis International Airport

    best
    1. Take the bus from Mobile to Crestviewbus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL)planeVPS - STL
    5h 52m
    $202–729

  2. Bus

    cheapest
    1. Take the bus from Mobile Bus Station to New Orleans Bus StationbusGreyhound US0602
    2. Take the bus from New Orleans Bus Station to St Louis Bus StationbusGreyhound US1173
    19h 57m
    $88–173

  3. Bus via Sandy Springs

    1. Take the bus from Mobile to AtlantabusHouston
    2. Take the bus from Atlanta Bus Station to St Louis Bus StationbusFlixBus N2521
    18h 54m
    $177–337

  4. Bus, train

    1. Take the bus from Mobile Bus Station to New Orleans Bus Stationbus
    2. Take the train from New Orleans Union Passenger Terminal to Carbondaletrain
    3. Take the bus from Carbondale to St. Louisbus
    21h 42m
    $155–283

  5. Drive 642.5 mi

    1. Drive from Mobile to St. Louiscar642.5 mi
    11h 52m
    $118–170

  6. Bus to Pensacola International Airport, fly to Lambert–St. Louis International Airport

    1. Take the bus from Mobile Bus Station to Pensacola Airportbus
    2. Fly from Pensacola International Airport (PNS) to Lambert–St. Louis International Airport (STL)planePNS - STL
    6h 15m
    $138–711

  7. Fly Mobile Regional Airport to Lambert–St. Louis International Airport

    1. Fly from Mobile Regional Airport (MOB) to Lambert–St. Louis International Airport (STL)planeMOB - STL
    8h 40m
    $124–659

  8. Bus to Destin–Fort Walton Beach Airport, fly to Midamerica St. Louis Airport

    1. Take the bus from Mobile to Crestviewbus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Midamerica St. Louis Airport (BLV)planeVPS - BLV
    6h 7m
    $185–508

  9. Bus to Gulfport-Biloxi Regional Airport, fly to Lambert–St. Louis International Airport

    1. Take the bus from Mobile to Gulfportbus
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Lambert–St. Louis International Airport (STL)planeGPT - STL
    8h 34m
    $242–881

Mobile to St. Louis by bus and train

Calendar7Weekly Services
Duration21h 42mAverage Duration
Ticket$155Cheapest Price
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Questions & Answers

What companies run services between Mobile, AL, USA and St. Louis, MO, USA?

You can take a bus from Mobile to St Louis Bus Station via Mobile, Atlanta, Doraville Station, Garnett Station, and Atlanta Bus Station in around 18h 54m. Alternatively, Delta, American Airlines, and United Airlines fly from Mobile Regional Airport (MOB) to Lambert–St. Louis International Airport (STL) every 3 hours.

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