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How to get fromMobile to St. Louisby bus, plane, train, car, or taxi

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There are 9 ways to get from Mobile to St. Louis by bus, plane, train, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Destin–Fort Walton Beach Airport, fly to Lambert–St. Louis International Airport

    best
    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL)plane plane VPS - STL
    5h 43m
    $222–779

  2. Drive 642.5 mi

    cheapest
    1. Drive from Mobile to St. Louiscar car 642.5 mi
    11h 47m
    $118–170

  3. Train, bus

    1. Take the train from Mobile, AL to New Orleans, LA - Union Passenger Terminaltrain train Mobile / ...
    2. Take the bus from New Orleans Bus Station to St Louis Bus Stationbus bus Greyhound US1173
    19h 23m
    $130–300

  4. Train, bus via Carbondale

    1. Take the train from Mobile, AL to New Orleans, LA - Union Passenger Terminaltrain train
    2. Take the train from New Orleans Union Passenger Terminal to Carbondaletrain train
    3. Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus bus
    21h 6m
    $222–530

  5. Bus to Pensacola International Airport, fly to Lambert–St. Louis International Airport

    1. Take the bus from Mobile Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Lambert–St. Louis International Airport (STL)plane plane PNS - STL
    6h 15m
    $122–671

  6. Fly Mobile Regional Airport to Lambert–St. Louis International Airport

    1. Fly from Mobile Regional Airport (MOB) to Lambert–St. Louis International Airport (STL)plane plane MOB - STL
    8h 17m
    $145–717

  7. Bus to Destin–Fort Walton Beach Airport, fly to Midamerica St. Louis Airport

    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Midamerica St. Louis Airport (BLV)plane plane VPS - BLV
    6h 3m
    $190–518

  8. Train to Louis Armstrong New Orleans International Airport, fly to Lambert–St. Louis International Airport

    1. Take the train from Mobile, AL to New Orleans, LA - Union Passenger Terminaltrain train
    2. Fly from Louis Armstrong New Orleans International Airport (MSY) to Lambert–St. Louis International Airport (STL)plane plane MSY - STL
    8h 32m
    $415–698

  9. Bus, taxi to Northwest Florida Beaches International Airport, fly to Lambert–St. Louis International Airport

    1. Take the bus from Love's Travel Stop - Loxley to Whataburger - Defuniak Springsbus bus
    2. Take the taxi from Whataburger - Defuniak Springs to Northwest Florida Beaches International Airport (ECP)taxi taxi
    3. Fly from Northwest Florida Beaches International Airport (ECP) to Lambert–St. Louis International Airport (STL)plane plane ECP - STL
    7h 27m
    $319–1,043

Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL) flights

Calendar26Weekly Planes
Duration3h 3mAverage Duration
Ticket$119Cheapest Price
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Questions & Answers

What companies run services between Mobile, AL, USA and St. Louis, MO, USA?

Delta, American Airlines, and United Airlines fly from Mobile Regional Airport (MOB) to Lambert–St. Louis International Airport (STL) every 3 hours.

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