There are 6 ways to get from Tupelo to Paducah by bus, car, plane, or bus (Greyhound, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, drive (Greyhound)
best- Take the bus from Tupelo to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Cape Girardeaubus
- Drive from Cape Girardeau to Paducahcar
7h 51m$78–135Drive 216.4 mi
cheapest- Drive from Tupelo to Paducahcar 216.4 mi
4h 35m$40–57Fly Tupelo Regional Airport to Nashville, bus
- Fly from Tupelo Regional Airport (TUP) to Nashville (BNA)plane TUP - BNA
- Take the bus from Nashville Bus Station to Paducah Bus Stationbus
5h 27m$99–377Bus
- Take the bus from Tupelo to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Nashville Bus Stationbus
- Take the bus from Nashville Bus Station to Paducah Bus Stationbus
10h 9m$96–212Drive to Northwest Alabama Regional Airport, fly to Barkley Regional Airport
- Drive from Tupelo to Northwest Alabama Regional Airport (MSL)car
- Fly from Northwest Alabama Regional Airport (MSL) to Barkley Regional Airport (PAH)plane MSL - PAH
7h 8m$281–1,154Fly Tupelo Regional Airport to Cape Girardeau Municipal Airport, drive
- Fly from Tupelo Regional Airport (TUP) to Cape Girardeau Municipal Airport (CGI)plane TUP - CGI
- Drive from Cape Girardeau Municipal Airport (CGI) to Paducahcar
9h 15m$189–739
Tupelo Regional Airport (TUP) to Nashville (BNA) flights
Questions & Answers
The cheapest way to get from Tupelo to Paducah is to drive which costs $35 - $60 and takes 4h 35m.
The fastest way to get from Tupelo to Paducah is to drive which takes 4h 35m and costs $35 - $60.
The distance between Tupelo and Paducah is 355 miles. The road distance is 217.7 miles.
The best way to get from Tupelo to Paducah without a car is to bus which takes 10h 9m and costs $95 - $220.
It takes approximately 7h 51m to get from Tupelo to Paducah, including transfers.
Yes, the driving distance between Tupelo to Paducah is 218 miles. It takes approximately 4h 35m to drive from Tupelo to Paducah.
There are 33+ hotels available in Paducah.
What companies run services between Tupelo, MS, USA and Paducah, KY, USA?
You can take a vehicle from Tupelo to Paducah via Tupelo, Memphis Bus Station, Nashville Bus Station, and Paducah Bus Station in around 10h 9m.
- Website
- contouraviation.com
Flights from Tupelo Regional Airport to Nashville
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- $55–260
Flights from Northwest Alabama Regional Airport to Barkley Regional Airport via Charlotte
- Ave. Duration
- 5h 37m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $240–1,100
Flights from Tupelo Regional Airport to Cape Girardeau Municipal Airport via Dallas/Ft.Worth
- Ave. Duration
- 9h 17m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $160–700
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Tupelo to Memphis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Twice daily
- Estimated price
- $20–29
- Website
- https://www.greyhound.com/
Bus from Memphis Bus Station to Cape Girardeau
- Ave. Duration
- 3h 15m
- Frequency
- Once daily
- Estimated price
- $35–75
- Website
- https://www.greyhound.com/
Bus from Memphis Bus Station to Nashville Bus Station
- Ave. Duration
- 3h 45m
- Frequency
- 4 times a day
- Estimated price
- $40–75
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Nashville Bus Station to Paducah Bus Station
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- $17–85
- Schedules at
- flixbus.com
- Adult
- $17–85
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide



