The average train between Isernia and Perugia takes 8h 18m and the fastest train takes 4h 57m. The train service runs several times per day from Isernia to Perugia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Isernia and Perugia. The earliest departure is at 6:40 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Perugia at 9:39 AM. All services require a transfer, and take on average 8h 18m. The schedules shown below are for the next available departures.

5h 26m • 1 change

8h 20m • 1 change

5h 31m • 1 change

4h 57m • 1 change

8h 20m • 1 change

6h 34m • 1 change
Arrives next day

14h 22m • 1 change

5h 26m • 1 change

8h 20m • 1 change

5h 31m • 1 change

4h 57m • 1 change

8h 20m • 1 change

5h 47m • 1 change
Arrives next day

13h 4m • 1 change

8h 20m • 1 change

5h 47m • 1 change
Arrives next day

13h 4m • 1 change
Want to know about travelling from Isernia to Perugia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Perugia. However, there are services departing from Isernia station and arriving at Perugia station via Roma Termini. The journey, including transfers, takes approximately 8h 18m.
Isernia to Perugia train services, operated by Trenitalia, depart from Isernia station.
Isernia to Perugia train services, operated by Trenitalia, arrive at Perugia station.
Book your Isernia to Perugia train tickets online with Trenitalia and Trenitalia Intercity.
The distance between Isernia and Perugia is 226.7 km. The road distance is 375 km.
You can take a train from Isernia to Perugia via Roma Termini in around 6h 3m.