The train between Isernia and Palermo takes 12h 32m. The train runs, on average, 2 times per week from Isernia to Palermo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice a week between Isernia and Palermo. The earliest departure is at 6:40 AM in the morning, and the last departure from Isernia is at 6:40 AM which arrives into Palermo at 7:12 PM. All services require a transfer, and take on average 12h 32m. The schedules shown below are for the next available departures.
Want to know about travelling from Isernia to Palermo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Palermo. However, there are services departing from Isernia station and arriving at Palermo station via Cassino. The journey, including transfers, takes approximately 12h 32m.
Isernia to Palermo train services, operated by Trenitalia, depart from Isernia station.
Isernia to Palermo train services, operated by Trenitalia, arrive at Palermo Centrale station.
Book your Isernia to Palermo train tickets online with Trenitalia and Trenitalia Intercity.
The distance between Isernia and Palermo is 392.7 km. The road distance is 805 km.
You can take a train from Isernia to Palermo Centrale via Cassino in around 13h 3m.
