The average train between Isernia and Brussels takes 21h 57m and the fastest train takes 15h 42m. The train service runs several times per day from Isernia to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Isernia and Brussels. The earliest departure is at 6:35 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Brussels at 9:47 PM. All services require a transfer at Roma Termini and take an average of 21h 57m. The schedules shown below are for the next available departures.




15h 42m • 4 changesArrives next day




23h 6m • 4 changesArrives next day




24h 41m • 4 changes



15h 42m • 4 changesArrives next day




23h 56m • 4 changesArrives next day




24h 41m • 4 changesArrives next day




25h 12m • 4 changesArrives next day




25h 1m • 4 changesArrives next day




25h 41m • 4 changesArrives next day




23h 6m • 4 changesArrives next day




24h 25m • 4 changes



16h 19m • 4 changesArrives next day




23h 6m • 4 changesArrives next day




24h 41m • 4 changesWant to know about travelling from Isernia to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Brussels. However, there are services departing from Isernia station and arriving at Brussels station via Roma Termini. The journey, including transfers, takes approximately 21h 57m.
Isernia to Brussels train services, operated by Trenitalia, depart from Isernia station.
Isernia to Brussels train services, operated by Trenitalia, arrive at Brussel-Zuid / Bruxelles-Midi station.
Book your Isernia to Brussels train tickets online with Trenitalia, Trenitalia Frecce and 3 other operators.
The distance between Isernia and Brussels is 1,277.2 km. The road distance is 1,920 km.
You can take a train from Isernia to Brussel-Zuid / Bruxelles-Midi via Roma Termini, Torino Porta Susa, Paris Gare de Lyon, and Paris Nord in around 15h 51m.