The average train between Isernia and Genoa takes 10h 7m and the fastest train takes 8h 15m. The train service runs several times per day from Isernia to Genoa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Isernia and Genoa. The earliest departure is at 6:40 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Genoa at 10:55 AM. All services require a transfer, and take on average 10h 7m. The schedules shown below are for the next available departures.

9h 49m • 1 change

8h 17m • 1 change

8h 15m • 1 change
Arrives next day

14h 20m • 1 change

9h 49m • 1 change

8h 17m • 1 change

8h 15m • 1 change
Arrives next day

14h 20m • 1 change

8h 17m • 1 change

8h 44m • 1 change
Arrives next day

14h 20m • 1 change

8h 17m • 1 change

8h 44m • 1 change
Arrives next day

14h 20m • 1 change

8h 17m • 1 change

8h 44m • 1 change
Arrives next day

14h 20m • 1 change
Want to know about travelling from Isernia to Genoa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Genoa. However, there are services departing from Isernia station and arriving at Genoa station via Roma Termini. The journey, including transfers, takes approximately 10h 7m.
Isernia to Genoa train services, operated by Trenitalia, depart from Isernia station.
Isernia to Genoa train services, operated by Trenitalia, arrive at Genova Brignole station.
Book your Isernia to Genoa train tickets online with Trenitalia, Trenitalia Intercity and Trenitalia Frecce.
The distance between Isernia and Genoa is 531.4 km. The road distance is 680 km.
You can take a train from Isernia to Genova Brignole via Roma Termini in around 7h 57m.