Train Isernia to Milan from €128 | Tickets & Timetables

Trip Overview

The average train between Isernia and Milan takes 7h 3m and the fastest train takes 5h 33m. The train service runs several times per day from Isernia to Milan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

7h 3m
Duration: 747 km
Distance: €128
Average price: 5 times a day
Frequency

Train

best

Take the train from Isernia to Roma Terminitrain Re
Take the train from Roma Termini to Milano Centraletrain Fr / ...

5h 51m

€99–198

Isernia to Milan train times

Trains run 5 times a day between Isernia and Milan. The earliest departure is at 6:40 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Milan at 8:30 AM. All services require a transfer, and take on average 7h 3m. The schedules shown below are for the next available departures.

Departing Thursday, April 30, 2026

6:00 PM → 12:00 AM
Arrives next day
6h • 1 change
8:35 PM → 9:50 AM
Arrives next day
13h 15m • 1 change

Departing Friday, May 1, 2026

6:40 AM → 12:24 PM
5h 44m • 1 change
8:38 AM → 2:50 PM
6h 12m • 1 change
3:19 PM → 9:00 PM
5h 41m • 1 change
5:27 PM → 11:00 PM
5h 33m • 1 change
Show more

Departing Saturday, May 2, 2026

6:40 AM → 12:24 PM
5h 44m • 1 change
8:38 AM → 2:50 PM
6h 12m • 1 change
3:03 PM → 9:00 PM
5h 57m • 1 change
6:00 PM → 12:20 AM
Arrives next day
6h 20m • 1 change
Show more

Departing Sunday, May 3, 2026

6:40 AM → 12:24 PM
5h 44m • 1 change
8:38 AM → 2:50 PM
6h 12m • 1 change
3:19 PM → 9:00 PM
5h 41m • 1 change
5:27 PM → 11:00 PM
5h 33m • 1 change
Show more

Departing Monday, May 4, 2026

6:40 AM → 12:24 PM
5h 44m • 1 change
8:38 AM → 2:35 PM
5h 57m • 1 change
3:03 PM → 9:00 PM
5h 57m • 1 change
6:00 PM → 12:20 AM
Arrives next day
6h 20m • 1 change
Show more

Departing Tuesday, May 5, 2026

6:40 AM → 12:24 PM
5h 44m • 1 change
8:38 AM → 2:35 PM
5h 57m • 1 change
3:03 PM → 9:00 PM
5h 57m • 1 change
6:00 PM → 12:20 AM
Arrives next day
6h 20m • 1 change
Show more

Departing Wednesday, May 6, 2026

6:40 AM → 12:24 PM
5h 44m • 1 change
8:38 AM → 2:35 PM
5h 57m • 1 change
3:03 PM → 9:00 PM
5h 57m • 1 change
6:00 PM → 12:20 AM
Arrives next day
6h 20m • 1 change

Frequently asked questions

Want to know about travelling from Isernia to Milan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.