Isernia to Milan Trains

Isernia to Milan trains

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Trip Overview

The average train between Isernia and Milan takes 7h 11m and the fastest train takes 5h 33m. The train service runs several times per day from Isernia to Milan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

7h 11m
Duration: 751 km
Distance: €121
Average price: 4 times a day
Frequency

Train

best

Take the train from Isernia to Roma Terminitrain Re
Take the train from Roma Termini to Milano Centraletrain Fr / ...

6h 24m

€87–170

Isernia to Milan train times

Trains run 4 times a day between Isernia and Milan. The earliest departure is at 6:40 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Milan at 8:30 AM. All services require a transfer, and take on average 7h 11m. The schedules shown below are for the next available departures.

Departing Wednesday, October 28, 2026

8:38 AM → 2:35 PM
5h 57m • 1 change
3:03 PM → 9:00 PM
5h 57m • 1 change
8:35 PM → 8:30 AM
Arrives next day
11h 55m • 1 change

Departing Thursday, October 29, 2026

6:40 AM → 12:24 PM
5h 44m • 1 change
8:38 AM → 2:35 PM
5h 57m • 1 change
3:03 PM → 9:00 PM
5h 57m • 1 change
8:35 PM → 8:30 AM
Arrives next day
11h 55m • 1 change

Departing Friday, October 30, 2026

6:40 AM → 12:24 PM
5h 44m • 1 change
8:38 AM → 2:35 PM
5h 57m • 1 change
3:03 PM → 9:00 PM
5h 57m • 1 change
8:35 PM → 8:50 AM
Arrives next day
12h 15m • 1 change

Departing Saturday, October 31, 2026

6:40 AM → 12:24 PM
5h 44m • 1 change
8:38 AM → 2:50 PM
6h 12m • 1 change
3:03 PM → 9:00 PM
5h 57m • 1 change
8:35 PM → 8:50 AM
Arrives next day
12h 15m • 1 change

Departing Sunday, November 1, 2026

6:40 AM → 12:24 PM
5h 44m • 1 change
8:38 AM → 2:50 PM
6h 12m • 1 change
3:19 PM → 9:00 PM
5h 41m • 1 change
5:27 PM → 11:00 PM
5h 33m • 1 change
Show more

Departing Monday, November 2, 2026

6:40 AM → 12:24 PM
5h 44m • 1 change
8:38 AM → 2:35 PM
5h 57m • 1 change
3:03 PM → 9:00 PM
5h 57m • 1 change
8:35 PM → 8:30 AM
Arrives next day
11h 55m • 1 change

Departing Tuesday, November 3, 2026

6:40 AM → 12:24 PM
5h 44m • 1 change
8:38 AM → 2:35 PM
5h 57m • 1 change
3:03 PM → 9:00 PM
5h 57m • 1 change

Frequently asked questions

Want to know about travelling from Isernia to Milan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.