The average train between Isernia and Milan takes 7h 12m and the fastest train takes 5h 33m. The train service runs several times per day from Isernia to Milan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Isernia and Milan. The earliest departure is at 6:40 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Milan at 8:30 AM. All services require a transfer, and take on average 7h 12m. The schedules shown below are for the next available departures.

5h 57m • 1 change

5h 57m • 1 change
Arrives next day

11h 55m • 1 change

5h 44m • 1 change

5h 57m • 1 change

5h 57m • 1 change
Arrives next day

12h 15m • 1 change

5h 44m • 1 change

6h 12m • 1 change

5h 57m • 1 change
Arrives next day

12h 15m • 1 change

5h 44m • 1 change

6h 35m • 1 change

5h 41m • 1 change

5h 33m • 1 change

5h 44m • 1 change

5h 57m • 1 change

5h 57m • 1 change
Arrives next day

11h 55m • 1 change
Want to know about travelling from Isernia to Milan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Milan. However, there are services departing from Isernia station and arriving at Milan station via Roma Termini. The journey, including transfers, takes approximately 7h 12m.
Isernia to Milan train services, operated by Trenitalia, depart from Isernia station.
Isernia to Milan train services, operated by Trenitalia, arrive at Milano Centrale station.
Book your Isernia to Milan train tickets online with Trenitalia and Trenitalia Frecce.
The distance between Isernia and Milan is 591.7 km. The road distance is 747 km.
You can take a train from Isernia to Milano Centrale via Roma Termini in around 5h 50m.