There are 5 ways to get from Isernia to Perugia by bus, train (Trenitalia), car, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Isernia to Roma, Autostazione TiburtinaCampobasso / ...
- Take the bus from Roma, Autostazione Tiburtina to Perugia538 / ...
5h 28m€17–75Train, bus
cheapest- Take the train from Isernia to CassinoRe
- Take the bus from Cassino to Perugia - Piazza Partigiani
6h 10m€8–10Train
- Take the train from Isernia to Roma TerminiRe
- Take the train from Roma Termini to Perugia4730 / ...
6h 3m€50–133Drive 324.6 km
- Drive from Isernia to Perugia324.6 km
3h 28m€51–73Train via Foligno
- Take the train from Isernia to Roma TerminiRe
- Take the train from Roma Termini to Foligno4154 / ...
6h 18m€52–102
Isernia to Perugia by bus
Questions & Answers
The cheapest way to get from Isernia to Perugia is to train and bus which costs €7 - €10 and takes 6h 10m.
The fastest way to get from Isernia to Perugia is to drive which takes 3h 28m and costs €50 - €75.
No, there is no direct bus from Isernia to Perugia. However, there are services departing from Isernia and arriving at Perugia via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 5h 28m.
No, there is no direct train from Isernia to Perugia. However, there are services departing from Isernia and arriving at Perugia via Roma Termini. The journey, including transfers, takes approximately 6h 3m.
The distance between Isernia and Perugia is 343 km. The road distance is 324.6 km.
The best way to get from Isernia to Perugia without a car is to bus which takes 5h 28m and costs €16 - €75.
It takes approximately 5h 28m to get from Isernia to Perugia, including transfers.
Isernia to Perugia bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., depart from Isernia station.
Isernia to Perugia train services, operated by Trenitalia S.p.A., depart from Isernia station.
The best way to get from Isernia to Perugia is to bus which takes 5h 28m and costs €16 - €75. Alternatively, you can train, which costs €50 - €140 and takes 6h 3m.
What companies run services between Isernia, Italy and Perugia, Italy?
You can take a bus from Isernia to Perugia via Roma, Autostazione Tiburtina in around 5h 28m. Alternatively, you can take a train from Isernia to Perugia via Roma Termini in around 6h 3m.
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Isernia to Roma Termini
- Ave. Duration
- 2h 25m
- Frequency
- 5 times a day
- Estimated price
- €35–60
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Perugia
- Ave. Duration
- 2h 38m
- Frequency
- 5 times a day
- Estimated price
- €40–75
- Website
- https://www.trenitalia.com/en.html
Train from Isernia to Cassino
- Ave. Duration
- 40 min
- Frequency
- Every 4 hours
- Estimated price
- €4–7
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Foligno
- Ave. Duration
- 1h 56m
- Frequency
- Hourly
- Estimated price
- €14–25
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Perugia
- Ave. Duration
- 2h 29m
- Frequency
- 6 times a week
- Estimated price
- €11–30
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Foligno
- Ave. Duration
- 1h 54m
- Frequency
- 3 times a day
- Estimated price
- €9–23
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Foligno
- Ave. Duration
- 1h 42m
- Frequency
- Once daily
- Estimated price
- €23–35
- Schedules at
- trenitalia.com
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Isernia to Roma, Autostazione Tiburtina
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Isernia to Roma, Autostazione Tiburtina
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- €14–40
- Website
- https://www.flixbus.co.uk
Bus from Roma, Autostazione Tiburtina to Perugia
- Ave. Duration
- 2h 20m
- Frequency
- Every 4 hours
- Estimated price
- €8–22
- Website
- https://www.flixbus.co.uk
- Phone
- +39 075 5009641
- info@sulga.it
- Website
- sulga.it
Bus from Roma, Autostazione Tiburtina to Perugia
- Ave. Duration
- 2h 15m
- Frequency
- 4 times a day
- Estimated price
- €22–26
- Schedules at
- sulga.it
- 2nd Class
- €22–26
- Phone
- +39 080 3112335
- info@marinobus.it
- Website
- marinobus.it
Bus from Roma, Autostazione Tiburtina to Perugia
- Ave. Duration
- 2h 40m
- Frequency
- Once daily
- Estimated price
- €18–35
- Website
- https://marinobus.it/en/
- Phone
- +39 0972 24590
- booking@autolineemoretti.it
- Website
- autolineemoretti.it
Bus from Roma, Autostazione Tiburtina to Perugia
- Ave. Duration
- 2h 15m
- Frequency
- 3 times a week
- Estimated price
- €12–14
- Schedules at
- autolineemoretti.it
- Phone
- 0971 54673
- info@autolineeliscio.it
- Website
- autolineeliscio.it
Bus from Roma, Autostazione Tiburtina to Perugia
- Ave. Duration
- 2h 30m
- Frequency
- Twice a week
- Estimated price
- €10–15
- Schedules at
- autolineeliscio.it
- Phone
- +39 089 233 899
- salerno@autolineecurcio.it
- Website
- autolineecurcio.it
Bus from Cassino to Perugia - Piazza Partigiani
- Ave. Duration
- 3h 40m
- Frequency
- Once daily
- Estimated price
- €2
- Website
- https://www.autolineecurcio.it/
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More Questions & Answers
Isernia to Perugia bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., arrive at Roma, Autostazione Tiburtina station.
Isernia to Perugia train services, operated by Trenitalia S.p.A., arrive at Roma Termini station.
Yes, the driving distance between Isernia to Perugia is 325 km. It takes approximately 3h 28m to drive from Isernia to Perugia.
Book your Isernia to Perugia train tickets online with Omio.
Book your Isernia to Perugia bus tickets online with Omio and FlixBus.
There are 1957+ hotels available in Perugia.






































