The average train between Isernia and Pisa takes 7h 29m and the fastest train takes 5h 13m. The train service runs several times per day from Isernia to Pisa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Isernia and Pisa. The earliest departure is at 6:40 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Pisa at 8:45 AM. All services require a transfer, and take on average 7h 29m. The schedules shown below are for the next available departures.

6h 54m • 1 change

6h 11m • 1 change

6h 17m • 1 change
Arrives next day

12h 10m • 1 change

6h 19m • 1 change

6h 11m • 1 change

6h 1m • 1 change

5h 13m • 1 change

6h 19m • 1 change

6h 11m • 1 change

6h 17m • 1 change
Arrives next day

12h 10m • 1 change

6h 19m • 1 change

6h 11m • 1 change

6h 1m • 1 change

5h 13m • 1 change
Want to know about travelling from Isernia to Pisa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Pisa. However, there are services departing from Isernia station and arriving at Pisa station via Roma Termini. The journey, including transfers, takes approximately 7h 29m.
Isernia to Pisa train services, operated by Trenitalia, depart from Isernia station.
Isernia to Pisa train services, operated by Trenitalia, arrive at Pisa Centrale station.
Book your Isernia to Pisa train tickets online with Trenitalia, Trenitalia Frecce and Trenitalia Intercity.
The distance between Isernia and Pisa is 391.5 km. The road distance is 522 km.
You can take a train from Isernia to Pisa Centrale via Roma Termini in around 5h 30m.