The average bus between Isernia and Perugia takes 5h 45m and the fastest bus takes 4h 30m. The bus service runs several times per day from Isernia to Perugia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Isernia and Perugia. The earliest departure is at 6:50 AM in the morning, and the last departure from Isernia is at 6:20 PM which arrives into Perugia at 11:10 PM. All services require a transfer, and take on average 5h 45m. The schedules shown below are for the next available departures.

4h 30m • 1 change

6h 25m • 1 change

6h 40m • 1 change

5h 25m • 1 change

4h 30m • 1 change

6h 25m • 1 change

6h 40m • 1 change

5h 25m • 1 change

4h 30m • 1 change

6h 25m • 1 change

6h 40m • 1 change

5h 25m • 1 change
Want to know about travelling from Isernia to Perugia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Isernia to Perugia. However, there are services departing from Isernia station and arriving at Perugia station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 5h 45m.
Isernia to Perugia bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., depart from Isernia station.
Isernia to Perugia bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., arrive at Perugia station.
Book your Isernia to Perugia bus tickets online with ATM Azienda di Trasporti Molisana S.p.A., FlixBus and Sulga Autolinee.
The distance between Isernia and Perugia is 226.7 km. The road distance is 343 km.
You can take a bus from Isernia to Perugia via Roma, Autostazione Tiburtina in around 5h 30m.