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How to get fromMurrells Inlet to Louisvilleby plane, bus (Greyhound, Flixbus, Amtrak), car, bus, or bus (Greyhound)

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There are 6 ways to get from Murrells Inlet to Louisville by plane, bus (Greyhound, Flixbus, Amtrak), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louisville International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Louisville International Airport (SDF)plane plane MYR - SDF
    5h 11m
    $122–521

  2. Fly to Blue Grass Airport, drive

    cheapest
    1. Fly from Myrtle Beach (MYR) to Blue Grass Airport (LEX)plane plane MYR - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 5m
    $104–367

  3. Bus via Atlanta

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    19h 11m
    $158–271

  4. Drive 618.1 mi

    1. Drive from Murrells Inlet to Louisvillecar car 618.1 mi
    12h 44m
    $113–163

  5. Fly to Covington, bus

    1. Fly from Myrtle Beach (MYR) to Covington (CVG)plane plane MYR - CVG
    2. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    5h 44m
    $492–745

  6. Bus

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville to Winston-Salembus bus
    3. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    4. Take the bus from Columbus - Downtown - Mound St to Louisville, KY Bus Stationbus bus
    29h 46m
    $175–356

Myrtle Beach (MYR) to Louisville International Airport (SDF) flights

Calendar63Weekly Planes
Duration4h 58mAverage Duration
Ticket$81Cheapest Price
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Comparing Your Travel Options

Map of how to get from Murrells Inlet to Louisville.ExpandLaunch map view
  • Distance: 511.2 mi
  • Duration: 5h 11m

What companies run services between Murrells Inlet, SC, USA and Louisville, KY, USA?

American Airlines, Delta, and Southwest Airlines fly from Myrtle Beach (MYR) to Louisville International Airport (SDF) every 3 hours. Alternatively, you can take a vehicle from Murrells Inlet to Louisville, KY via Myrtle Beach Bus Station, Atlanta Bus Station, and Nashville in around 19h 11m.

Airlines
Bus operators

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