Rome2Rio

How to get fromKey West to Louisvilleby plane, bus (Greyhound, Flixbus, Amtrak), car or bus

Find Transport to Louisville

See all options

There are 7 ways to get from Key West to Louisville by plane, bus (Greyhound, Flixbus, Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louisville International Airport

    best
    1. Fly from Key West International Airport (EYW) to Louisville International Airport (SDF)plane plane EYW - SDF
    5h 33m
    $163–817
  2. Fly to Blue Grass Airport, drive

    cheapest
    1. Fly from Key West International Airport (EYW) to Blue Grass Airport (LEX)plane plane EYW - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 36m
    $125–583
  3. Bus

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    5. Take the bus from Nashville to Louisville, KYbus bus
    30h 12m
    $147–349
  4. Drive 1,179.1 mi

    1. Drive from Key West to Louisvillecar car 1,179.1 mi
    21h 58m
    $216–311
  5. Fly to Covington, bus

    1. Fly from Key West International Airport (EYW) to Covington (CVG)plane plane EYW - CVG
    2. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    6h 55m
    $233–1,161
  6. Fly to Evansville, bus

    1. Fly from Key West International Airport (EYW) to Evansville (EVV)plane plane EYW - EVV
    2. Take the bus from Evansville, IN to Louisville, KYbus bus
    8h 57m
    $167–644
  7. Bus via Tallahassee

    1. Take the bus from N Roosevelt & 3rd Street to Big Pine Key - Auto Store / NAPA MM30bus bus Lks
    2. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Tallahasseebus bus
    4. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    5. Take the bus from Nashville to Louisville, KYbus bus
    32h 2m
    $177–379

Key West to Louisville by bus and foot

Calendar14Weekly Services
Duration30h 12mAverage Duration
Ticket$147Cheapest Price
See schedules

Questions & Answers

What companies run services between Key West, FL, USA and Louisville, KY, USA?

Delta, Allegiant Air, and two other airlines fly from Key West International Airport (EYW) to Louisville International Airport (SDF) 5 times a day. Alternatively, you can take a bus from N Roosevelt & 3rd Street to Louisville, KY via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Atlanta Bus Station, and Nashville in around 30h 12m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers