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How to get fromMurrells Inlet to Lake Cityby car, train, bus, bus (Greyhound), or plane

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There are 8 ways to get from Murrells Inlet to Lake City by car, train, bus, bus (Greyhound), or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, train, bus

    best
    1. Drive from Murrells Inlet to Kingstree Stationcar car
    2. Take the train from Kingstree Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    9h 57m
    $116–237

  2. Drive 371.3 mi

    cheapest
    1. Drive from Murrells Inlet to Lake Citycar car 371.3 mi
    7h
    $68–98

  3. Bus (Greyhound)

    1. Take the bus from Myrtle Beach Bus Station to Sumter Bus Stopbus bus
    2. Take the bus from Sumter Bus Stop to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    15h 46m
    $127–223

  4. Fly to Jacksonville, bus

    1. Fly from Myrtle Beach (MYR) to Jacksonville (JAX)plane plane MYR - JAX
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    7h 23m
    $321–918

  5. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    10h 44m
    $147–258

  6. Fly to Orlando, bus

    1. Fly from Myrtle Beach (MYR) to Orlando (MCO)plane plane MYR - MCO
    2. Take the bus from Orlando Bus Station to Lake City Bus Stationbus bus
    8h 22m
    $143–427

  7. Fly to Gainesville Regional Airport, bus

    1. Fly from Myrtle Beach (MYR) to Gainesville Regional Airport (GNV)plane plane MYR - GNV
    2. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    8h 35m
    $106–384

  8. Fly to Valdosta, bus

    1. Fly from Myrtle Beach (MYR) to Valdosta (VLD)plane plane MYR - VLD
    2. Take the bus from Valdosta to Gainesville Bus Stopbus bus
    3. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    10h 50m
    $130–425

Myrtle Beach (MYR) to Jacksonville (JAX) flights

Calendar63Weekly Planes
Duration5h 8mAverage Duration
Ticket$62Cheapest Price
See schedules

Questions & Answers

Map of how to get from Murrells Inlet to Lake City.ExpandLaunch map view
  • Distance: 434.4 mi
  • Duration: 9h 57m

What companies run services between Murrells Inlet, SC, USA and Lake City, FL, USA?

You can take a vehicle from Murrells Inlet to Lake City Bus Station via Myrtle Beach Bus Station, Sumter Bus Stop, and Jacksonville in around 15h 46m.

Airlines
Train operators
Bus operators

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