Rome2Rio

How to get fromMurrells Inlet to Lake Cityby car, train, bus or plane

Find Transport to Lake City

See all options

There are 7 ways to get from Murrells Inlet to Lake City by car, train, bus, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, train, bus

    best
    1. Drive from Murrells Inlet to Kingstree Stationcar car
    2. Take the train from Kingstree Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    9h 57m
    $102–229

  2. Drive 371.3 mi

    cheapest
    1. Drive from Murrells Inlet to Lake Citycar car 371.3 mi
    7h
    $68–98

  3. Fly to Jacksonville, bus

    1. Fly from Myrtle Beach (MYR) to Jacksonville (JAX)plane plane MYR - JAX
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    7h 27m
    $432–1,070

  4. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    11h 9m
    $135–258

  5. Fly to Orlando, bus

    1. Fly from Myrtle Beach (MYR) to Orlando (MCO)plane plane MYR - MCO
    2. Take the bus from Orlando Bus Station to Lake City Bus Stationbus bus
    8h 22m
    $141–372

  6. Fly to Gainesville Regional Airport, bus

    1. Fly from Myrtle Beach (MYR) to Gainesville Regional Airport (GNV)plane plane MYR - GNV
    2. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    8h 44m
    $111–425

  7. Fly to Valdosta, bus

    1. Fly from Myrtle Beach (MYR) to Valdosta (VLD)plane plane MYR - VLD
    2. Take the bus from Valdosta to Gainesville Bus Stopbus bus
    3. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    8h 46m
    $136–463

Myrtle Beach (MYR) to Jacksonville (JAX) flights

Calendar75Weekly Planes
Duration4h 46mAverage Duration
Ticket$79Cheapest Price
See schedules

Questions & Answers

What companies run services between Murrells Inlet, SC, USA and Lake City, FL, USA?

There is no direct connection from Murrells Inlet to Lake City. However, you can drive to Kingstree Station, take the train to Jacksonville, walk to Amtrak Station, take the line 4 bus to JRTC Bay H, walk to Jacksonville, then take the bus to Lake City Bus Station. Alternatively, you can drive from Murrells Inlet to Lake City in around 7h.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Trips from Murrells Inlet

Trips to Lake City

Popular routes