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How to get fromMurrells Inlet to Lake Cityby car, train, bus or plane

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There are 7 ways to get from Murrells Inlet to Lake City by car, train, bus, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, train, bus

    best
    1. Drive from Murrells Inlet to Kingstree Stationcar car
    2. Take the train from Kingstree Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    10h 7m
    $86–199

  2. Drive 371.3 mi

    cheapest
    1. Drive from Murrells Inlet to Lake Citycar car 371.3 mi
    7h
    $68–98

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    11h 19m
    $126–235

  4. Fly to Jacksonville, bus

    1. Fly from Myrtle Beach (MYR) to Jacksonville (JAX)plane plane MYR - JAX
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    7h 40m
    $292–872

  5. Fly to Gainesville Regional Airport, bus

    1. Fly from Myrtle Beach (MYR) to Gainesville Regional Airport (GNV)plane plane MYR - GNV
    2. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    8h 48m
    $107–407

  6. Fly to Orlando, bus

    1. Fly from Myrtle Beach (MYR) to Orlando (MCO)plane plane MYR - MCO
    2. Take the bus from Orlando Bus Station to Lake City Bus Stationbus bus
    8h 17m
    $151–384

  7. Fly to Valdosta, bus

    1. Fly from Myrtle Beach (MYR) to Valdosta (VLD)plane plane MYR - VLD
    2. Take the bus from Valdosta to Gainesville Bus Stopbus bus
    3. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    10h 48m
    $132–455

Myrtle Beach (MYR) to Jacksonville (JAX) flights

Calendar65Weekly Planes
Duration4h 45mAverage Duration
Ticket$70Cheapest Price
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Questions & Answers

What companies run services between Murrells Inlet, SC, USA and Lake City, FL, USA?

There is no direct connection from Murrells Inlet to Lake City. However, you can drive to Kingstree Station, take the train to Jacksonville, walk to Amtrak Station, take the line 4 bus to JRTC Bay H, walk to Jacksonville, then take the bus to Lake City Bus Station. Alternatively, you can take a vehicle from Murrells Inlet to Lake City Bus Station via Myrtle Beach Bus Station, Charleston Bus Station, Charleston Amtrak Station, Jacksonville, Amtrak Station, JRTC Bay H, and Jacksonville in around 11h 19m.

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