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How to get fromMurrells Inlet to Buffaloby plane, bus (Greyhound, Flixbus), car, train, bus, or bus (Greyhound)

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There are 7 ways to get from Murrells Inlet to Buffalo by plane, bus (Greyhound, Flixbus), car, train, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)plane plane MYR - BUF
    3h 36m
    $146–676

  2. Drive  770.7 mi

    cheapest
    1. Drive from Murrells Inlet to Buffalocar car 770.7 mi
    15h 48m
    $137–197

  3. Bus

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville Bus Station to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to Buffalobus bus
    23h 31m
    $221–336

  4. Drive, train (Amtrak)

    1. Drive from Murrells Inlet to Kingstree Stationcar car
    2. Take the train from Kingstree Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    24h 21m
    $621–996

  5. Fly to Rochester, bus

    1. Fly from Myrtle Beach (MYR) to Rochester (ROC)plane plane MYR - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    5h 5m
    $201–841

  6. Bus via Raleigh

    1. Take the bus from Myrtle Beach Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Buffalobus bus
    24h 51m
    $238–541

  7. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the train from Fayetteville Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    25h 19m
    $611–946

Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) flights

Calendar46Weekly Planes
Duration3h 55mAverage Duration
Ticket$103Cheapest Price
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Comparing Your Travel Options

Map of how to get from Murrells Inlet to Buffalo.ExpandLaunch map view
  • Distance: 662.1 mi
  • Duration: 3h 36m

What companies run services between Murrells Inlet, SC, USA and Buffalo, NY, USA?

Breeze Airways, Southwest Airlines, and two other airlines fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, you can take a vehicle from Murrells Inlet to Buffalo via Myrtle Beach Bus Station, Fayetteville Bus Station, and Newark Penn Station in around 23h 31m.

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