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How to get fromMurrells Inlet to Buffaloby plane, car, train, bus (Greyhound, Flixbus), bus or bus (Greyhound)

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There are 7 ways to get from Murrells Inlet to Buffalo by plane, car, train, bus (Greyhound, Flixbus), bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)plane plane MYR - BUF
    5h 16m
    $227–1,178

  2. Drive 770.3 mi

    cheapest
    1. Drive from Murrells Inlet to Buffalocar car 770.3 mi
    15h 52m
    $141–204

  3. Drive, train (Amtrak)

    1. Drive from Murrells Inlet to Kingstree Stationcar car
    2. Take the train from Kingstree Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    24h 33m
    $256–597

  4. Bus

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Cape Fear Public Transit to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Newark Penn Stationbus bus
    4. Take the bus from Newark Penn Station to Buffalobus bus
    24h 51m
    $199–391

  5. Fly to Rochester, bus

    1. Fly from Myrtle Beach (MYR) to Rochester (ROC)plane plane MYR - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus bus
    5h 41m
    $187–733

  6. Bus via Chesapeake

    1. Take the bus from Myrtle Beach Bus Station to Norfolkbus bus
    2. Take the bus from Norfolk, VA - Best Square to Times Square – 37th St.bus bus
    3. Take the bus from New York to Buffalobus bus
    26h 12m
    $210–503

  7. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    27h 15m
    $316–683

Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) flights

Calendar60Weekly Planes
Duration4h 38mAverage Duration
Ticket$183Cheapest Price
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Questions & Answers

What companies run services between Murrells Inlet, SC, USA and Buffalo, NY, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) every 3 hours. Alternatively, you can take a vehicle from Murrells Inlet to Buffalo via Myrtle Beach Bus Station, Wilmington Cape Fear Public Transit, Raleigh Bus Station, and Newark Penn Station in around 24h 51m.

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