There are 8 ways to get from Murrells Inlet to Buffalo by plane, car, train, bus (Greyhound, Flixbus), bus, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Buffalo Niagara International Airport
best- Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)plane MYR - BUF
5h 6m$217–1,078Fly to Niagara Falls International Airport, line 40 bus
cheapest- Fly from Myrtle Beach (MYR) to Niagara Falls International Airport (IAG)plane MYR - IAG
- Take the bus from Main Street & Walnut Avenue to Niagara Street & South Elmwood Avenuebus
4h 55m$106–414Drive, train (Amtrak)
- Drive from Murrells Inlet to Kingstree Stationcar
- Take the train from Kingstree Station to Ny Moynihan Train Hall At Penn Stationtrain
- Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain
24h 33m$271–627Bus
- Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus
- Take the bus from Wilmington Cape Fear Public Transit to Raleigh Bus Stationbus
- Take the bus from Raleigh Bus Station to Newark Penn Stationbus
- Take the bus from Newark Penn Station to Buffalobus
24h 51m$205–402Drive 770.3 mi
- Drive from Murrells Inlet to Buffalocar 770.3 mi
15h 52m$141–204Fly to Rochester, bus
- Fly from Myrtle Beach (MYR) to Rochester (ROC)plane MYR - ROC
- Take the bus from Rochester Bus Stop to Buffalobus
4h 51m$198–845Bus via Chesapeake
- Take the bus from Myrtle Beach Bus Station to Norfolkbus
- Take the bus from Norfolk, VA - Best Square to Times Square – 37th St.bus
- Take the bus from New York to Buffalobus
26h 12m$215–503Bus, train
- Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus
- Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain
- Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain
27h 15m$331–723
Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) flights
Questions & Answers
The cheapest way to get from Murrells Inlet to Buffalo is to drive which costs $140 - $210 and takes 15h 52m.
The fastest way to get from Murrells Inlet to Buffalo is to fly and bus which takes 4h 51m and costs $190 - $850.
The distance between Murrells Inlet and Buffalo is 666 miles. The road distance is 774.8 miles.
The best way to get from Murrells Inlet to Buffalo without a car is to bus which takes 24h 51m and costs $200 - $410.
It takes approximately 5h 6m to get from Murrells Inlet to Buffalo, including transfers.
The best way to get from Murrells Inlet to Buffalo is to fly which takes 5h 6m and costs $210 - $1,100. Alternatively, you can bus, which costs $200 - $410 and takes 24h 51m.
Yes, the driving distance between Murrells Inlet to Buffalo is 775 miles. It takes approximately 15h 52m to drive from Murrells Inlet to Buffalo.
There are 258+ hotels available in Buffalo.
What companies run services between Murrells Inlet, SC, USA and Buffalo, NY, USA?
Southwest Airlines, Delta, and American Airlines fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, you can take a vehicle from Murrells Inlet to Buffalo via Myrtle Beach Bus Station, Wilmington Cape Fear Public Transit, Raleigh Bus Station, and Newark Penn Station in around 24h 51m.
- Website
- aa.com
Flights from Myrtle Beach to Buffalo Niagara International Airport via Philadelphia
- Ave. Duration
- 4h 27m
- When
- Every day
- Estimated price
- $190–1,100
Flights from Myrtle Beach to Buffalo Niagara International Airport via Charlotte
- Ave. Duration
- 5h 11m
- When
- Tuesday and Saturday
- Estimated price
- $180–1,100
Flights from Myrtle Beach to Buffalo Niagara International Airport via Reagan Washington
- Ave. Duration
- 4h 43m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $170–1,000
Flights from Myrtle Beach to Buffalo Niagara International Airport via New York La Guardia
- Ave. Duration
- 7h 19m
- When
- Sunday
- Estimated price
- $200–1,100
Flights from Myrtle Beach to Rochester via Charlotte
- Ave. Duration
- 4h 27m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–600
Flights from Myrtle Beach to Rochester via Philadelphia
- Ave. Duration
- 4h 12m
- When
- Every day
- Estimated price
- $100–600
Flights from Myrtle Beach to Rochester via Reagan Washington
- Ave. Duration
- 4h 31m
- When
- Every day
- Estimated price
- $100–600
- Website
- southwest.com
Flights from Myrtle Beach to Buffalo Niagara International Airport via Baltimore
- Ave. Duration
- 3h 50m
- When
- Every day
- Estimated price
- $180–1,100
Flights from Myrtle Beach to Buffalo Niagara International Airport via Nashville
- Ave. Duration
- 6h 50m
- When
- Saturday and Sunday
- Estimated price
- $240–1,300
Flights from Myrtle Beach to Rochester via Baltimore
- Ave. Duration
- 4h 20m
- When
- Every day
- Estimated price
- $100–600
- Website
- delta.com
Flights from Myrtle Beach to Buffalo Niagara International Airport via Detroit
- Ave. Duration
- 4h 8m
- When
- Every day
- Estimated price
- $210–1,200
Flights from Myrtle Beach to Buffalo Niagara International Airport via New York La Guardia
- Ave. Duration
- 4h 24m
- When
- Every day
- Estimated price
- $200–1,100
Flights from Myrtle Beach to Rochester via Detroit
- Ave. Duration
- 4h 13m
- When
- Saturday
- Estimated price
- $120–650
Flights from Myrtle Beach to Rochester via New York La Guardia
- Ave. Duration
- 4h 46m
- When
- Every day
- Estimated price
- $110–650
- Website
- flybreeze.com
Flights from Myrtle Beach to Rochester
- Ave. Duration
- 2h 5m
- When
- Thursday and Sunday
- Estimated price
- $120–800
- Website
- allegiantair.com
Flights from Myrtle Beach to Niagara Falls International Airport
- Ave. Duration
- 1h 51m
- When
- Monday and Friday
- Estimated price
- $60–360
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Kingstree Station to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 13h 14m
- Frequency
- Twice daily
- Estimated price
- $160–370
- Website
- https://www.amtrak.com/home.html
Train from Ny Moynihan Train Hall At Penn Station to Buffalo
- Ave. Duration
- 8h 45m
- Frequency
- 3 times a day
- Estimated price
- $100–240
- Website
- https://www.amtrak.com/home.html
Train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 13h 44m
- Frequency
- Twice daily
- Estimated price
- $170–400
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transit
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $13–24
- Website
- https://www.greyhound.com/
Bus from Wilmington Cape Fear Public Transit to Raleigh Bus Station
- Ave. Duration
- 2h 55m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- https://www.greyhound.com/
Bus from Raleigh Bus Station to Newark Penn Station
- Ave. Duration
- 9h 10m
- Frequency
- 3 times a day
- Estimated price
- $80–150
- Website
- https://www.greyhound.com/
Bus from Newark Penn Station to Buffalo
- Ave. Duration
- 8h 35m
- Frequency
- Once daily
- Estimated price
- $65–130
- Website
- https://www.greyhound.com/
Bus from Rochester Bus Stop to Buffalo
- Ave. Duration
- 1h 25m
- Frequency
- 4 times a day
- Estimated price
- $12–23
- Website
- https://www.greyhound.com/
Bus from Myrtle Beach Bus Station to Norfolk
- Ave. Duration
- 8h 45m
- Frequency
- Once daily
- Estimated price
- $60–110
- Website
- https://www.greyhound.com/
Bus from Myrtle Beach Bus Station to Charleston Bus Station
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- $16–30
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Newark Penn Station to Buffalo
- Ave. Duration
- 7h 45m
- Frequency
- 5 times a day
- Estimated price
- $45–85
- Schedules at
- flixbus.com
Bus from Rochester Bus Stop to Buffalo
- Ave. Duration
- 1h 20m
- Frequency
- Every 3 hours
- Estimated price
- $8–15
- Schedules at
- flixbus.com
- Phone
- +1 716-855-7211
- info@nfta.com
- Website
- metro.nfta.com
Bus from Main Street & Walnut Avenue to Niagara Street & South Elmwood Avenue
- Ave. Duration
- 56 min
- Frequency
- Hourly
- Estimated price
- $2
- Website
- https://metro.nfta.com
- Phone
- +1 757-456-5555
- Website
- sprinterbus.net
Bus from Norfolk, VA - Best Square to Times Square – 37th St.
- Ave. Duration
- 7h
- Frequency
- Once daily
- Estimated price
- $50–60
- Website
- https://www.sprinterbus.net
- Passenger
- $50–60
- Phone
- +1 800-858-8555
- Website
- trailways.com
Bus from New York to Buffalo
- Ave. Duration
- 8h
- Frequency
- Every 4 hours
- Estimated price
- $60–280
- Website
- https://trailways.com
- Schedules at
- https://trailways.com/schedules/
- Saver
- $60–260
- Flexible
- $110–280
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