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How to get fromMurrells Inlet to Buffaloby plane, car, train, bus (Greyhound), bus or bus (Flixbus)

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There are 7 ways to get from Murrells Inlet to Buffalo by plane, car, train, bus (Greyhound), bus, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)planeMYR - BUF
    4h 53m
    $244–1,252

  2. Drive 770.4 mi

    cheapest
    1. Drive from Murrells Inlet to Buffalocar770.4 mi
    15h 45m
    $141–204

  3. Drive, train (Amtrak)

    1. Drive from Murrells Inlet to Kingstree Amtrak Stationcar
    2. Take the train from Kingstree Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain
    24h 32m
    $221–517

  4. Bus via Columbus

    1. Take the bus from Myrtle Beach, SC to Charlotte Bus Stationbus
    2. Take the bus from Charlotte Bus Station to Columbusbus
    3. Take the bus from Columbus - Mound St to Buffalo, NYbus
    25h 56m
    $185–413

  5. Fly to Rochester, bus

    1. Fly from Myrtle Beach (MYR) to Rochester (ROC)planeMYR - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus
    5h 41m
    $196–465

  6. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus
    2. Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain
    26h 50m
    $247–578

  7. Bus

    1. Take the bus from Myrtle Beach, SC to Charlotte Bus Stationbus
    2. Take the bus from Charlotte Bus Station to New York Midtownbus
    3. Take the bus from New York Midtown to Buffalobus
    29h 38m
    $230–388

Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) flights

Calendar82Weekly Planes
Duration4h 52mAverage Duration
Ticket$204Cheapest Price
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Questions & Answers

What companies run services between Murrells Inlet, SC, USA and Buffalo, NY, USA?

Southwest Airlines, American Airlines, and Delta fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) every 2 hours. Alternatively, you can take a vehicle from Murrells Inlet to Buffalo, NY via Myrtle Beach, SC, Charlotte Bus Station, and Columbus - Mound St in around 25h 56m.

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