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How to get fromMurrells Inlet to Buffaloby plane, bus (Greyhound, Flixbus), car, train, bus, or bus (Greyhound)

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There are 7 ways to get from Murrells Inlet to Buffalo by plane, bus (Greyhound, Flixbus), car, train, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)plane plane MYR - BUF
    5h 1m
    $146–626

  2. Drive  770.3 mi

    cheapest
    1. Drive from Murrells Inlet to Buffalocar car 770.3 mi
    15h 52m
    $141–204

  3. Bus

    1. Take the bus from Myrtle Beach Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to Buffalobus bus
    23h 46m
    $213–336

  4. Drive, train (Amtrak)

    1. Drive from Murrells Inlet to Kingstree Stationcar car
    2. Take the train from Kingstree Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    24h 22m
    $311–797

  5. Fly to Rochester, bus

    1. Fly from Myrtle Beach (MYR) to Rochester (ROC)plane plane MYR - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    5h 5m
    $200–839

  6. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the train from Fayetteville Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    24h 49m
    $337–781

  7. Bus via Columbus

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville to Winston-Salembus bus
    3. Take the bus from Winston Salem to Columbusbus bus
    4. Take the bus from Columbus - Mound St to Buffalo, NYbus bus
    26h 26m
    $166–296

Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) flights

Calendar99Weekly Planes
Duration5h 3mAverage Duration
Ticket$99Cheapest Price
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Comparing Your Travel Options

Map of how to get from Murrells Inlet to Buffalo.ExpandLaunch map view
  • Distance: 662.1 mi
  • Duration: 5h 1m

What companies run services between Murrells Inlet, SC, USA and Buffalo, NY, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a vehicle from Murrells Inlet to Buffalo via Myrtle Beach Bus Station, Raleigh Bus Station, and Newark Penn Station in around 23h 46m.

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