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How to get fromMurrells Inlet to Buffaloby plane, car, train, bus (Greyhound), bus or bus (Flixbus)

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There are 7 ways to get from Murrells Inlet to Buffalo by plane, car, train, bus (Greyhound), bus, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)plane plane MYR - BUF
    5h 26m
    $216–1,130

  2. Drive 770.4 mi

    cheapest
    1. Drive from Murrells Inlet to Buffalocar car 770.4 mi
    15h 52m
    $141–204

  3. Drive, train (Amtrak)

    1. Drive from Murrells Inlet to Kingstree Stationcar car
    2. Take the train from Kingstree Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    24h 33m
    $236–557

  4. Bus via Columbus

    1. Take the bus from Myrtle Beach, SC to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Bus Station to Columbusbus bus
    3. Take the bus from Columbus - Mound St to Buffalo, NYbus bus
    25h 56m
    $185–433

  5. Fly to Rochester, bus

    1. Fly from Myrtle Beach (MYR) to Rochester (ROC)plane plane MYR - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus bus
    5h 41m
    $196–595

  6. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    27h 15m
    $241–628

  7. Bus

    1. Take the bus from Myrtle Beach, SC to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Bus Station to New York Midtownbus bus
    3. Take the bus from New York Midtown to Buffalobus bus
    29h 47m
    $225–423

Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) flights

Calendar74Weekly Planes
Duration4h 42mAverage Duration
Ticket$174Cheapest Price
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Questions & Answers

What companies run services between Murrells Inlet, SC, USA and Buffalo, NY, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) every 2 hours. Alternatively, you can take a vehicle from Murrells Inlet to Buffalo, NY via Myrtle Beach, SC, Charlotte Bus Station, and Columbus - Mound St in around 25h 56m.

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Need to know: Greyhound

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