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How to get fromIndianapolis to Buffaloby plane, bus, train, bus (Greyhound), car, shuttle, bus (Flixbus) or train (Amtrak)

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There are 8 ways to get from Indianapolis to Buffalo by plane, bus, train, bus (Greyhound), car, shuttle, bus (Flixbus), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Indianapolis (IND) to Buffalo Niagara International Airport (BUF)plane plane IND - BUF
    6h 53m
    $196–1,282

  2. Bus

    cheapest
    1. Take the bus from Indianapolis Union Station to Cincinnati Bus Stationbus bus Greyhound US0120
    2. Take the bus from Cincinnati, OH to Buffalo, NYbus bus Cinncinati,OH-Buffalo
    12h 15m
    $69–169

  3. Bus, train

    1. Take the bus from Indianapolis, IN to Toledobus bus Cincinnati
    2. Take the train from Toledo to Buffalo Depew Stationtrain train Lake Shore Limited
    11h 38m
    $121–275

  4. Drive 494.8 mi

    1. Drive from Indianapolis to Buffalocar car 494.8 mi
    8h 33m
    $91–131

  5. Fly to Rochester, bus

    1. Fly from Indianapolis (IND) to Rochester (ROC)plane plane IND - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus bus
    9h 1m
    $206–737

  6. Fly to Toronto Pearson International Airport, shuttle

    1. Fly from Indianapolis (IND) to Toronto Pearson International Airport (YYZ)plane plane IND - YYZ
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    8h 5m
    $266–682

  7. Bus via Pittsburgh

    1. Take the bus from Indianapolis to Pittsburgh Intermodal Stationbus bus FlixBus N2640
    2. Take the bus from Pittsburgh to Buffalobus bus Fab510
    15h 50m
    $83–261

  8. Train (Amtrak)

    1. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    17h 44m
    $110–482

Indianapolis to Buffalo by bus and train

Calendar7Weekly Services
Duration11h 38mAverage Duration
Ticket$121Cheapest Price
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Questions & Answers

What companies run services between Indianapolis, IN, USA and Buffalo, NY, USA?

Delta, Southwest Airlines, and two other airlines fly from Indianapolis (IND) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Indianapolis Union Station to Buffalo, NY via Cincinnati Bus Station and Cincinnati, OH in around 12h 15m.

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