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How to get fromIndianapolis to Buffaloby bus (Greyhound), bus, train, car, plane, bus (Flixbus), train (Amtrak) or shuttle

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There are 8 ways to get from Indianapolis to Buffalo by bus (Greyhound), bus, train, car, plane, bus (Flixbus), train (Amtrak), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Toledo

    best
    1. Take the bus from Indianapolis, IN to Toledobus bus
    2. Take the bus from Toledo Bus Stop to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    11h 5m
    $51–165

  2. Bus, train

    1. Take the bus from Indianapolis, IN to Toledobus bus Cincinnati
    2. Take the train from Toledo to Buffalo Depew Stationtrain train Lake Shore Limited
    11h 38m
    $53–265

  3. Drive 494.8 mi

    1. Drive from Indianapolis to Buffalocar car 494.8 mi
    8h 33m
    $91–131

  4. Fly to Buffalo Niagara International Airport

    1. Fly from Indianapolis (IND) to Buffalo Niagara International Airport (BUF)plane plane IND - BUF
    6h 41m
    $166–1,082

  5. Bus

    1. Take the bus from Indianapolis to Pittsburgh Intermodal Stationbus bus FlixBus N2640
    2. Take the bus from Pittsburgh to Buffalobus bus Fab510
    15h 50m
    $83–262

  6. Train (Amtrak)

    1. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    17h 44m
    $110–340

  7. Fly to Rochester, bus

    1. Fly from Indianapolis (IND) to Rochester (ROC)plane plane IND - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus bus
    8h 59m
    $206–687

  8. Fly to Toronto Pearson International Airport, shuttle

    1. Fly from Indianapolis (IND) to Toronto Pearson International Airport (YYZ)plane plane IND - YYZ
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    8h 5m
    $266–622

Indianapolis to Buffalo by bus

Calendar7Weekly Buses
Duration11h 5mAverage Duration
Ticket$51Cheapest Price
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Questions & Answers

What companies run services between Indianapolis, IN, USA and Buffalo, NY, USA?

You can take a bus from Indianapolis, IN to Buffalo, NY via Toledo Bus Stop, Cleveland Bus Station, and Cleveland, OH in around 11h 5m. Alternatively, Delta, Southwest Airlines, and two other airlines fly from Indianapolis (IND) to Buffalo Niagara International Airport (BUF) hourly.

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Need to know: Greyhound

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