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There are 7 ways to get from Indianapolis to Buffalo by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Buffalo  •  5 h 38 min

  1. Fly from Indianapolis (IND) to Buffalo (BUF) IND - BUF

$164 - $434

Cheapest option

Bus  •  13 h 10 min

  1. Take the bus from Indianapolis, IN to University of Cincinnati
  2. Take the bus from University of Cincinnati, OH to Buffalo, NY Cinncinati,OH-Buffalo

$52 - $117

5 alternative options

Fly to Toronto, bus  •  7 h 34 min

  1. Fly from Indianapolis (IND) to Toronto (YYZ) IND - YYZ
  2. Take the bus from Toronto, ON to Buffalo, NY

$180 - $515

Fly to Rochester, train  •  8 h 29 min

  1. Fly from Indianapolis (IND) to Rochester (ROC) IND - ROC
  2. Take the train from Rochester Amtrak to Buffalo Exchange Street Amtrak

$179 - $858

Train  •  17 h 29 min

  1. Take the train from Indianapolis Amtrak to Chicago Union Station Hoosier State / ...
  2. Take the train from Chicago Union Station to Buffalo Depew Station Amtrak Lake Shore Limited

$135 - $353

Bus, Thru-Bus  •  18 h 49 min

  1. Take the bus from Indianapolis, IN to Ann Arbor, MI
  2. Take the bus from Ann Arbor, MI to Hamilton, ON
  3. Take the Thru-Bus from Hamilton, ON to Buffalo, NY

$82 - $189

Drive  •  8 h 27 min

  1. Drive from Indianapolis to Buffalo 502.7 miles

$45 - $75

Questions & Answers

The cheapest way to get from Indianapolis to Buffalo is to drive which costs $45 - $75 and takes 8 h 27 min.

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The quickest way to get from Indianapolis to Buffalo is to fly which costs $160 - $440 and takes 5 h 38 min.

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No, there is no direct bus from Indianapolis to Buffalo. However, there are services departing from Indianapolis, IN and arriving at Buffalo, NY via University of Cincinnati, OH. The journey, including transfers, takes approximately 13 h 10 min.

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No, there is no direct train from Indianapolis to Buffalo. However, there are services departing from Indianapolis Amtrak and arriving at Buffalo Exchange Street Amtrak via Chicago Union Station and Buffalo Depew Station Amtrak. The journey, including transfers, takes approximately 17 h 29 min.

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The distance between Indianapolis and Buffalo is 437 miles. The road distance is 502.7 miles.

Get driving directions

The best way to get from Indianapolis to Buffalo without a car is to bus which takes 13 h 10 min and costs $50 - $120.

More details

It takes approximately 5 h 38 min to get from Indianapolis to Buffalo, including transfers.

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Indianapolis to Buffalo bus services, operated by Megabus, depart from Indianapolis, IN station.

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Indianapolis to Buffalo train services, operated by Amtrak, depart from Indianapolis Amtrak station.

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The best way to get from Indianapolis to Buffalo is to fly which takes 5 h 38 min and costs $160 - $440. Alternatively, you can bus, which costs $50 - $120 and takes 13 h 10 min, you could also train, which costs $130 - $360 and takes 17 h 29 min.

Mode details

Map of how to get from Indianapolis to Buffalo.
Launch map view
  • Distance: 437.1 miles
  • Duration: 5 h 38 min

What companies run services between Indianapolis, IN, USA and Buffalo, NY, USA?

Southwest Airlines, Delta and two other airlines fly from Indianapolis to Buffalo hourly. Alternatively, you can take a bus from Indianapolis to Buffalo via University of Cincinnati and University of Cincinnati, OH in around 13 h 10 min.

Airlines
United Airlines
Website
united.com
Flights from Indianapolis to Buffalo via Washington Dulles
Ave. Duration
3 h 50 min
When
Every day
Estimated price
$170 - $750
Flights from Indianapolis to Buffalo via Chicago O'Hare
Ave. Duration
3 h 46 min
When
Every day
Estimated price
$170 - $750
Flights from Indianapolis to Toronto
Ave. Duration
1 h 37 min
When
Every day
Estimated price
$200 - $1,400
Flights from Indianapolis to Toronto via Chicago O'Hare
Ave. Duration
3 h 46 min
When
Monday, Tuesday, Wednesday, Friday, Saturday and Sunday
Estimated price
$210 - $1,000
Flights from Indianapolis to Toronto via Washington Dulles
Ave. Duration
3 h 50 min
When
Every day
Estimated price
$210 - $1,000
Flights from Indianapolis to Rochester via Washington Dulles
Ave. Duration
3 h 56 min
When
Every day
Estimated price
$190 - $900
Flights from Indianapolis to Rochester via Chicago O'Hare
Ave. Duration
3 h 51 min
When
Every day
Estimated price
$180 - $900
American Airlines
Website
aa.com
Flights from Indianapolis to Buffalo via Chicago O'Hare
Ave. Duration
4 h
When
Every day
Estimated price
$170 - $850
Flights from Indianapolis to Buffalo via Reagan Washington
Ave. Duration
3 h 50 min
When
Every day
Estimated price
$170 - $850
Flights from Indianapolis to Toronto via Chicago O'Hare
Ave. Duration
4 h 4 min
When
Every day
Estimated price
$330 - $950
Flights from Indianapolis to Rochester via Chicago O'Hare
Ave. Duration
3 h 59 min
When
Every day
Estimated price
$170 - $850
Flights from Indianapolis to Rochester via Reagan Washington
Ave. Duration
4 h 8 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $850
Flights from Indianapolis to Rochester via Philadelphia
Ave. Duration
4 h 18 min
When
Saturday
Estimated price
$180 - $850
Flights from Indianapolis to Rochester via Charlotte
Ave. Duration
4 h 27 min
When
Every day
Estimated price
$190 - $900
Delta
Website
delta.com
Flights from Indianapolis to Buffalo via Detroit
Ave. Duration
3 h 34 min
When
Monday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$170 - $700
Flights from Indianapolis to Toronto via Detroit
Ave. Duration
3 h 41 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,000
Flights from Indianapolis to Rochester via Detroit
Ave. Duration
3 h 52 min
When
Every day
Estimated price
$150 - $800
Flights from Indianapolis to Rochester via New York La Guardia
Ave. Duration
4 h 25 min
When
Every day
Estimated price
$170 - $850
Southwest Airlines
Website
southwest.com
Flights from Indianapolis to Buffalo via Chicago Midway
Ave. Duration
3 h 28 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$390 - $750
Flights from Indianapolis to Buffalo via Baltimore
Ave. Duration
3 h 51 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$390 - $750
Flights from Indianapolis to Rochester via Baltimore
Ave. Duration
3 h 50 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $800
Air Canada
Website
aircanada.com
Flights from Indianapolis to Buffalo via Chicago O'Hare
Ave. Duration
3 h 46 min
When
Every day
Estimated price
$170 - $750
Flights from Indianapolis to Toronto
Ave. Duration
1 h 37 min
When
Every day
Estimated price
$200 - $1,400
Flights from Indianapolis to Toronto via Chicago O'Hare
Ave. Duration
3 h 49 min
When
Monday, Tuesday, Wednesday, Friday, Saturday and Sunday
Estimated price
$210 - $1,000
Flights from Indianapolis to Rochester via Chicago O'Hare
Ave. Duration
3 h 51 min
When
Every day
Estimated price
$180 - $900
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Rochester Amtrak to Buffalo Exchange Street Amtrak
Ave. Duration
1 h 17 min
Frequency
3 times a day
Estimated price
$26 - $55
Website
amtrak.com
Coach Seat
$26 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$35 - $55
Room
$140 - $210
Train from Indianapolis Amtrak to Chicago Union Station
Ave. Duration
5 h
Frequency
Once daily
Estimated price
$40 - $100
Website
amtrak.com
Coach Seat
$40 - $60
Flexi Coach Seat
$70 - $110
Business Coach Seat
$70 - $100
Room
$200 - $280
Train from Chicago Union Station to Buffalo Depew Station Amtrak
Ave. Duration
10 h 16 min
Frequency
Twice daily
Estimated price
$75 - $220
Website
amtrak.com
Coach Seat
$75 - $120
Flexi Coach Seat
$140 - $200
Business Coach Seat
$150 - $220
Room
$330 - $460
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Rochester to Buffalo
Ave. Duration
1 h 22 min
Frequency
Once daily
Estimated price
$40 - $85
Website
viarail.ca
Escape
$19 - $40
Economy
$40 - $55
EconomyPlus
$55 - $85
Business
$55 - $80
Bus operators
Greyhound Canada
Phone
+1 1-800-661-8747
Email
Canada.info@greyhound.ca
Website
greyhound.ca
Bus from Toronto, ON to Buffalo, NY
Ave. Duration
1 h 37 min
Frequency
Once daily
Estimated price
$14 - $40
Website
Greyhound.ca
Advanced Purchase
$14 - $21
Online Fare
$16 - $35
Standard Fare
$25 - $40
Refundable
$29 - $45
Bus from Ann Arbor, MI to Hamilton, ON
Ave. Duration
5 h 54 min
Frequency
Once daily
Estimated price
$25 - $65
Website
Greyhound.ca
Advanced Purchase
$25 - $40
Online Fare
$30 - $50
Standard Fare
$40 - $65
Refundable
$45 - $70
Bus from Hamilton, ON to Buffalo, NY
Ave. Duration
2 h 40 min
Frequency
Once daily
Estimated price
$12 - $35
Website
Greyhound.ca
Advanced Purchase
$12 - $18
Online Fare
$13 - $27
Standard Fare
$21 - $35
Refundable
$25 - $40
Megabus Canada
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Toronto, ON to Buffalo, NY
Ave. Duration
2 h 10 min
Frequency
4 times a day
Estimated price
$11 - $21
Book at
megabus.com
Bus from Indianapolis, IN to University of Cincinnati
Ave. Duration
2 h 10 min
Frequency
3 times a day
Estimated price
$12 - $22
Book at
megabus.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Toronto, On to Buffalo, Ny
Ave. Duration
3 h 45 min
Frequency
5 times a day
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $24
Flexible
$28 - $40

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

There is no direct flight from Indianapolis Airport to Buffalo Airport. The quickest flight takes 3 h 10 min and has one stopover.

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Indianapolis to Buffalo bus services, operated by Barons Bus, arrive at Buffalo, NY station.

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Indianapolis to Buffalo train services, operated by Amtrak, arrive at Buffalo Depew Station Amtrak.

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Yes, the driving distance between Indianapolis to Buffalo is 503 miles. It takes approximately 8 h 27 min to drive from Indianapolis to Buffalo.

Get driving directions

Delta, American Airlines, United Airlines and Southwest Airlines offer flights from Indianapolis Airport to Buffalo Airport.

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Book your Indianapolis to Buffalo train tickets online with Rome2rio.

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There are 139+ hotels available in Buffalo. Prices start at $62 USD per night.

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The best way to get from Indianapolis to Indianapolis Airport is to line 8 bus which takes 39 min and costs $2.

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