The average train between Trieste and Isernia takes 13h 19m and the fastest train takes 8h 45m. The train service runs several times per day from Trieste to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Trieste and Isernia. The earliest departure is at 6:38 AM in the morning, and the last departure from Trieste is at 2:27 PM which arrives into Isernia at 8:27 AM. All services require a transfer, and take on average 13h 19m. The schedules shown below are for the next available departures.

10h 2m • 1 change

11h 34m • 1 change
Arrives next day

18h • 1 change

8h 45m • 1 change

14h 5m • 1 change
Arrives next day

18h • 1 change

8h 45m • 1 change

14h 5m • 1 change
Arrives next day

18h • 1 change

8h 45m • 1 change

14h 5m • 1 change
Arrives next day

18h • 1 change
Want to know about travelling from Trieste to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Trieste to Isernia. However, there are services departing from Trieste station and arriving at Isernia station via Roma Termini. The journey, including transfers, takes approximately 13h 19m.
Trieste to Isernia train services, operated by Trenitalia Intercity, depart from Trieste Centrale station.
Trieste to Isernia train services, operated by Trenitalia Intercity, arrive at Isernia station.
Book your Trieste to Isernia train tickets online with Trenitalia Intercity, Trenitalia and Trenitalia Frecce.
The distance between Trieste and Isernia is 452.2 km. The road distance is 830 km.
You can take a train from Trieste Centrale to Isernia via Roma Termini in around 8h 45m.