The average train between Milan and Isernia takes 6h 19m and the fastest train takes 5h 57m. There is at least one train per day from Milan to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run once daily between Milan and Isernia. The earliest departure is at 9:26 AM in the morning, and the last departure from Milan is at 9:26 AM which arrives into Isernia at 3:23 PM. All services require a transfer, and take on average 6h 19m. The schedules shown below are for the next available departures.
Want to know about travelling from Milan to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Milan to Isernia. However, there are services departing from Milan station and arriving at Isernia station via Roma Termini. The journey, including transfers, takes approximately 6h 19m.
Milan to Isernia train services, operated by ItaloTreno, depart from Milan Rogoredo station.
Milan to Isernia train services, operated by ItaloTreno, arrive at Isernia station.
Book your Milan to Isernia train tickets online with ItaloTreno and Trenitalia.
The distance between Milan and Isernia is 591.7 km. The road distance is 739 km.
You can take a train from Milan Rogoredo to Isernia via Roma Termini in around 6h 10m.
