The average bus between Milan and Isernia takes 16h 12m and the fastest bus takes 10h 50m. There is at least one bus per day from Milan to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Milan and Isernia. The earliest departure is at 11:10 PM at night, and the last departure from Milan is at 11:10 PM which arrives into Isernia at 4:10 PM. All services require a transfer, and take on average 16h 12m. The schedules shown below are for the next available departures.
Want to know about travelling from Milan to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Milan to Isernia. However, there are services departing from Milan station and arriving at Isernia station via Termoli Autostazione. The journey, including transfers, takes approximately 16h 12m.
Milan to Isernia bus services, operated by FlixBus, depart from Milano, San Donato M3 station.
Milan to Isernia bus services, operated by FlixBus, arrive at Isernia station.
Book your Milan to Isernia bus tickets online with FlixBus and ATM Azienda di Trasporti Molisana S.p.A..
The distance between Milan and Isernia is 591.7 km. The road distance is 784 km.
You can take a bus from Milano, San Donato M3 to Isernia via Termoli Terminal Bus in around 8h 55m.
