There are 11 ways to get from Milan to Isernia by train, bus, car, plane, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train
best- Take the train from Milan Rogoredo to Roma Termini9987 / ...
- Take the train from Roma Termini to IserniaRe
6h 1m€57–137Bus via Termoli
cheapest- Take the bus from Milano - San Donato to Termoli AutostazioneVieste
- Take the bus from Termoli Terminal Bus to IserniaCb 014 / ...
14h 7m€37–55Bus
- Take the bus from Milano, San Donato M3 to San Salvo MarinaN424
- Take the bus from San Salvo Marina to IserniaTermoli-Rome tiburtina
10h 51m€40–100Drive 725.5 km
- Drive from Milan to Isernia725.5 km
6h 40m€112–162Fly Milan Linate Airport to Naples Airport, train
- Fly from Milan Linate Airport (LIN) to Naples Airport (NAP)LIN - NAP
- Take the train from Napoli Centrale to Isernia
5h 57m€56–190Train via Milan Centrale
- Take the train from Milano Centrale to Roma TerminiFr / ...
- Take the train from Roma Termini to IserniaRe
6h 20m€57–129Train to Milano Malpensa Airport, fly to Naples Airport, train
- Take the train from Milano Porta Garibaldi to Malpensa Aeroporto T1
- Fly from Milano Malpensa Airport (MXP) to Naples Airport (NAP)MXP - NAP
- Take the train from Napoli Centrale to Isernia
6h 31m€42–183Bus to Il Caravaggio International Airport, fly to Naples Airport, train
- Take the bus from Piazza Luigi di Savoia to Bergamo Airport Bus Station
- Fly from Il Caravaggio International Airport (BGY) to Naples Airport (NAP)BGY - NAP
- Take the train from Napoli Centrale to Isernia
6h 40m€58–215Fly Milan Linate Airport to Fiumicino International Airport, train
- Fly from Milan Linate Airport (LIN) to Fiumicino International Airport (FCO)LIN - FCO
- Take the train from Roma Termini to Isernia
6h 12m€61–195Train to Milano Malpensa Airport, fly to Foggia Gino Lisa Airport, bus
- Take the train from Milano Porta Garibaldi to Malpensa Aeroporto T1
- Fly from Milano Malpensa Airport (MXP) to Foggia Gino Lisa Airport (FOG)MXP - FOG
- Take the bus from Foggia to Isernia
6h 50m€82–249Train to Milano Malpensa Airport, fly to Abruzzo Airport, bus
- Take the train from Milano Porta Garibaldi to Malpensa Aeroporto T1
- Fly from Milano Malpensa Airport (MXP) to Abruzzo Airport (PSR)MXP - PSR
- Take the bus from Pescara to Isernia
7h 48m€42–222
Milan to Isernia by train
Questions & Answers
The cheapest way to get from Milan to Isernia is to bus via Termoli which costs €35 - €55 and takes 14h 7m.
The fastest way to get from Milan to Isernia is to fly and train which takes 5h 57m and costs €55 - €190.
No, there is no direct bus from Milan to Isernia. However, there are services departing from Milano, San Donato M3 and arriving at Isernia via San Salvo Marina. The journey, including transfers, takes approximately 10h 51m.
No, there is no direct train from Milan to Isernia. However, there are services departing from Milan Rogoredo and arriving at Isernia via Roma Termini. The journey, including transfers, takes approximately 6h 1m.
The distance between Milan and Isernia is 741 km. The road distance is 725.5 km.
The best way to get from Milan to Isernia without a car is to train which takes 6h 1m and costs €55 - €140.
It takes approximately 6h 1m to get from Milan to Isernia, including transfers.
Milan to Isernia bus services, operated by FlixBus, depart from Milano, San Donato M3 station.
Milan to Isernia train services, operated by ItaloTreno, depart from Milan Rogoredo station.
The best way to get from Milan to Isernia is to train which takes 6h 1m and costs €55 - €140. Alternatively, you can bus, which costs €40 - €100 and takes 10h 51m.
What companies run services between Milan, Italy and Isernia, Italy?
You can take a train from Milan Rogoredo to Isernia via Roma Termini in around 6h 1m. Alternatively, you can take a bus from Milano, San Donato M3 to Isernia via San Salvo Marina in around 10h 51m.
- Website
- ryanair.com
Flights from Milano Malpensa Airport to Naples Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €40–150
Flights from Il Caravaggio International Airport to Naples Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €45–170
Flights from Il Caravaggio International Airport to Naples Airport via Cagliari
- Ave. Duration
- 3h 40m
- When
- Monday and Sunday
- Estimated price
- €45–170
Flights from Milano Malpensa Airport to Abruzzo Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €29–150
- Website
- ita-airways.com
Flights from Milan Linate Airport to Naples Airport
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- €40–170
Flights from Milan Linate Airport to Naples Airport via Fiumicino International Airport
- Ave. Duration
- 3h
- When
- Monday to Saturday
- Estimated price
- €40–170
Flights from Milan Linate Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €45–150
- Website
- easyjet.com
Flights from Milano Malpensa Airport to Naples Airport
- Ave. Duration
- 1h 29m
- When
- Every day
- Estimated price
- €26–140
- Website
- aeroitalia.com
Flights from Milano Malpensa Airport to Foggia Gino Lisa Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €65–650
- Website
- flexflight.dk
Flights from Milano Malpensa Airport to Foggia Gino Lisa Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €65–650
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Milan Rogoredo to Roma Termini
- Ave. Duration
- 2h 53m
- Frequency
- Hourly
- Estimated price
- €45–120
- Website
- https://www.italotreno.it/en
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 39m
- Frequency
- Hourly
- Estimated price
- €45–120
- Website
- https://www.italotreno.it/en
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €11–17
- Website
- https://www.trenitalia.com/en.html
Train from Napoli Centrale to Isernia
- Ave. Duration
- 2h 3m
- Frequency
- 4 times a day
- Estimated price
- €8–13
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 12m
- Frequency
- Every 30 minutes
- Estimated price
- €50–120
- Schedules at
- trenitalia.com
- Phone
- +39 02 7249 4494
- my-link@trenord.it
- Website
- trenord.it
Train from Milano Porta Garibaldi to Malpensa Aeroporto T1
- Ave. Duration
- 41 min
- Frequency
- Hourly
- Estimated price
- €4–6
- Website
- https://www.trenord.it/en/
- Phone
- +39 02-72494949
- Website
- malpensaexpress.it
Train from Milano Porta Garibaldi to Malpensa Aeroporto T1
- Ave. Duration
- 41 min
- Frequency
- Hourly
- Estimated price
- €15
- Website
- https://www.malpensaexpress.it/en/
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Milano, San Donato M3 to San Salvo Marina
- Ave. Duration
- 8h 39m
- Frequency
- Once daily
- Estimated price
- €35–95
- Website
- https://www.flixbus.co.uk
Bus from Foggia to Isernia
- Ave. Duration
- 2h 9m
- Frequency
- Once daily
- Estimated price
- €12–35
- Website
- https://www.flixbus.co.uk
Bus from Pescara to Isernia
- Ave. Duration
- 2h 29m
- Frequency
- Twice daily
- Estimated price
- €18–35
- Website
- https://www.flixbus.co.uk
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from San Salvo Marina to Isernia
- Ave. Duration
- 1h 12m
- Frequency
- Once a week
- Estimated price
- €4–6
- Schedules at
- atm-molise.it
Bus from Termoli Terminal Bus to Isernia
- Ave. Duration
- 1h 35m
- Frequency
- Once a week
- Estimated price
- €5–8
- Schedules at
- atm-molise.it
Bus from Pescara to Isernia
- Ave. Duration
- 2h 15m
- Frequency
- Twice daily
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
- Phone
- +39 (0) 0882 - 228960
- Website
- ferroviedelgargano.com
Bus from Milano - San Donato to Termoli Autostazione
- Ave. Duration
- 10h 21m
- Frequency
- Once daily
- Estimated price
- €30–45
- Schedules at
- ferroviedelgargano.com
- info@flibco.com
- Website
- flibco.com
Bus from Piazza Luigi di Savoia to Bergamo Airport Bus Station
- Ave. Duration
- 50 min
- Frequency
- Every 30 minutes
- Estimated price
- €8–10
- Website
- https://www.flibco.com/en
- Phone
- +39 02 3008 9000
- mail@autostradale.it
- Website
- autostradale.it
Bus from Piazza Luigi di Savoia to Bergamo Airport Bus Station
- Ave. Duration
- 1h
- Frequency
- Every 30 minutes
- Estimated price
- €4–17
- Website
- https://autostradale.it/?lang=en-GB
- Standard Rate
- €13–17
Want to know more about travelling around Italy
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More Questions & Answers
Milan to Isernia bus services, operated by FlixBus, arrive at San Salvo Marina station.
Milan to Isernia train services, operated by ItaloTreno, arrive at Roma Termini station.
Yes, the driving distance between Milan to Isernia is 726 km. It takes approximately 6h 40m to drive from Milan to Isernia.
There are 422+ hotels available in Isernia.













































