There are 11 ways to get from Milan to Isernia by train (Trenitalia), bus, car, plane, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train
best- Take the train from Milano Centrale to Roma Terminitrain Fr / ...
- Take the train from Roma Termini to Iserniatrain Re
6h 20m€97–197Train to Milano Malpensa Airport, fly to Abruzzo Airport, bus
cheapest- Take the train from Milano Porta Garibaldi to Malpensa Aeroporto T1train
- Fly from Milano Malpensa Airport (MXP) to Abruzzo Airport (PSR)plane MXP - PSR
- Take the bus from Pescara to Iserniabus
7h 50m€42–177Bus
- Take the bus from Milano, San Donato M3 to Termoli Autostazionebus Turin
- Take the bus from Termoli Terminal Bus to Iserniabus Cb 014 / ...
8h 50m€51–96Drive 725.6 km
- Drive from Milan to Iserniacar 725.6 km
6h 44m€112–162Fly Milan Linate Airport to Naples Airport, train
- Fly from Milan Linate Airport (LIN) to Naples Airport (NAP)plane LIN - NAP
- Take the train from Caserta to Iserniatrain
6h 18m€59–175Train via Milan Rogoredo
- Take the train from Milan Rogoredo to Roma Terminitrain 9975 / ...
- Take the train from Roma Termini to Iserniatrain Re
6h 31m€95–181Bus via Florence
- Take the bus from Milano, San Donato M3 to Florence Villa Constanza Bus Stationbus N528 / ...
- Take the bus from Florence Villa Constanza Bus Station to Iserniabus 433
14h 19m€60–108Fly Milan Linate Airport to Fiumicino International Airport, train
- Fly from Milan Linate Airport (LIN) to Fiumicino International Airport (FCO)plane LIN - FCO
- Take the train from Roma Termini to Iserniatrain
6h 12m€74–189Fly Milan Linate Airport to Foggia Gino Lisa Airport, bus
- Fly from Milan Linate Airport (LIN) to Foggia Gino Lisa Airport (FOG)plane LIN - FOG
- Take the bus from Foggia to Iserniabus
6h 21m€82–262Train to Milano Malpensa Airport, fly to Naples Airport, train
- Take the train from Milano Porta Garibaldi to Malpensa Aeroporto T1train
- Fly from Milano Malpensa Airport (MXP) to Naples Airport (NAP)plane MXP - NAP
- Take the train from Caserta to Iserniatrain
6h 59m€44–158Bus to Il Caravaggio International Airport, fly to Naples Airport, train
- Take the bus from Piazza Luigi di Savoia to Bergamo Airport Bus Stationbus
- Fly from Il Caravaggio International Airport (BGY) to Naples Airport (NAP)plane BGY - NAP
- Take the train from Caserta to Iserniatrain
7h 1m€51–218
Milan to Isernia by train
Questions & Answers
The cheapest way to get from Milan to Isernia is to bus which costs €50 - €100 and takes 8h 50m.
The fastest way to get from Milan to Isernia is to fly and train which takes 6h 12m and costs €70 - €190.
No, there is no direct bus from Milan to Isernia. However, there are services departing from Milano, San Donato M3 and arriving at Isernia via Termoli Terminal Bus. The journey, including transfers, takes approximately 8h 50m.
No, there is no direct train from Milan to Isernia. However, there are services departing from Milano Centrale and arriving at Isernia via Roma Termini. The journey, including transfers, takes approximately 6h 20m.
The distance between Milan and Isernia is 747 km. The road distance is 725.6 km.
The best way to get from Milan to Isernia without a car is to train which takes 6h 20m and costs €95 - €200.
It takes approximately 6h 20m to get from Milan to Isernia, including transfers.
Milan to Isernia bus services, operated by FlixBus, depart from Milano, San Donato M3 station.
Milan to Isernia train services, operated by Trenitalia Frecce, depart from Milano Centrale station.
The best way to get from Milan to Isernia is to train which takes 6h 20m and costs €95 - €200. Alternatively, you can bus, which costs €50 - €100 and takes 8h 50m.
What companies run services between Milan, Italy and Isernia, Italy?
You can take a train from Milano Centrale to Isernia via Roma Termini in around 6h 20m. Alternatively, you can take a bus from Milano, San Donato M3 to Isernia via Termoli Terminal Bus in around 8h 50m.
- Website
- ryanair.com
Flights from Milano Malpensa Airport to Naples Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €29–130
Flights from Milano Malpensa Airport to Naples Airport via Alghero
- Ave. Duration
- 3h 45m
- When
- Monday, Wednesday, and Friday
- Estimated price
- €29–130
Flights from Il Caravaggio International Airport to Naples Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €35–160
Flights from Il Caravaggio International Airport to Naples Airport via Cagliari
- Ave. Duration
- 3h 40m
- When
- Friday
- Estimated price
- €35–160
Flights from Il Caravaggio International Airport to Naples Airport via Palermo
- Ave. Duration
- 3h 40m
- When
- Tuesday
- Estimated price
- €35–160
Flights from Milano Malpensa Airport to Abruzzo Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €29–130
- Website
- ita-airways.com
Flights from Milan Linate Airport to Naples Airport
- Ave. Duration
- 1h 24m
- When
- Every day
- Estimated price
- €45–150
Flights from Milan Linate Airport to Naples Airport via Fiumicino International Airport
- Ave. Duration
- 3h 22m
- When
- Every day
- Estimated price
- €45–150
Flights from Milan Linate Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €45–140
Flights from Milano Malpensa Airport to Naples Airport via Zurich
- Ave. Duration
- 3h 40m
- When
- Every day
- Estimated price
- €70–280
- Website
- easyjet.com
Flights from Milano Malpensa Airport to Naples Airport
- Ave. Duration
- 1h 31m
- When
- Every day
- Estimated price
- €30–130
- Website
- aeroitalia.com
Flights from Milan Linate Airport to Foggia Gino Lisa Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €70–400
- Website
- flexflight.dk
Flights from Milan Linate Airport to Foggia Gino Lisa Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €70–400
- Website
- flyulendo.com
Flights from Milano Malpensa Airport to Naples Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €15–140
- Website
- swiss.com
Flights from Milano Malpensa Airport to Naples Airport via Zurich
- Ave. Duration
- 3h 40m
- When
- Every day
- Estimated price
- €70–280
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 12m
- Frequency
- Every 30 minutes
- Estimated price
- €80–160
- Schedules at
- trenitalia.com
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 50m
- Frequency
- Once daily
- Estimated price
- €70–150
- Website
- https://www.italotreno.it/en
Train from Milan Rogoredo to Roma Termini
- Ave. Duration
- 3h 23m
- Frequency
- Twice daily
- Estimated price
- €70–150
- Website
- https://www.italotreno.it/en
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €23–40
- Website
- https://www.trenitalia.com/en.html
Train from Caserta to Isernia
- Ave. Duration
- 1h 18m
- Frequency
- 5 times a day
- Estimated price
- €11–19
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 02 7249 4494
- my-link@trenord.it
- Website
- trenord.it
Train from Milano Porta Garibaldi to Malpensa Aeroporto T1
- Ave. Duration
- 43 min
- Frequency
- Every 30 minutes
- Estimated price
- €4–6
- Website
- https://www.trenord.it/en/
- Phone
- +39 (0) 0882 - 228960
- Website
- ferroviedelgargano.com
Bus from Milano, San Donato M3 to Termoli Autostazione
- Ave. Duration
- 6h 15m
- Frequency
- Once daily
- Estimated price
- €50–90
- Schedules at
- ferroviedelgargano.com
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- https://www.flixbus.fr
Bus from Milano, San Donato M3 to Termoli Autostazione
- Ave. Duration
- 9h
- Frequency
- Once daily
- Estimated price
- €45–80
- Website
- https://www.flixbus.co.uk
Bus from Milano, San Donato M3 to Florence Villa Constanza Bus Station
- Ave. Duration
- 3h 25m
- Frequency
- Every 3 hours
- Estimated price
- €19–35
- Website
- https://www.flixbus.co.uk
Bus from Florence Villa Constanza Bus Station to Isernia
- Ave. Duration
- 9h 54m
- Frequency
- Once daily
- Estimated price
- €40–75
- Website
- https://www.flixbus.co.uk
Bus from Foggia to Isernia
- Ave. Duration
- 2h 9m
- Frequency
- Once daily
- Estimated price
- €9–16
- Website
- https://www.flixbus.co.uk
Bus from Pescara to Isernia
- Ave. Duration
- 2h 29m
- Frequency
- Once daily
- Estimated price
- €11–20
- Website
- https://www.flixbus.co.uk
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Termoli Terminal Bus to Isernia
- Ave. Duration
- 1h 35m
- Frequency
- Once a week
- Estimated price
- €5–9
- Schedules at
- atm-molise.it
Bus from Pescara to Isernia
- Ave. Duration
- 2h 15m
- Frequency
- Twice daily
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
- info@flibco.com
- Website
- flibco.com
Bus from Piazza Luigi di Savoia to Bergamo Airport Bus Station
- Ave. Duration
- 50 min
- Frequency
- Hourly
- Estimated price
- €8–21
- Website
- https://www.flibco.com/en
- customerservices@terravision.eu
- Website
- terravision.eu
Bus from Piazza Luigi di Savoia to Bergamo Airport Bus Station
- Ave. Duration
- 50 min
- Frequency
- Every 30 minutes
- Estimated price
- €5–25
- Website
- https://www.terravision.eu/
- Phone
- +39 02 3008 9000
- mail@autostradale.it
- Website
- autostradale.it
Bus from Piazza Luigi di Savoia to Bergamo Airport Bus Station
- Ave. Duration
- 1h
- Frequency
- Every 30 minutes
- Estimated price
- €4–8
- Website
- https://autostradale.it/?lang=en-GB
Want to know more about travelling around Italy
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More Questions & Answers
Milan to Isernia bus services, operated by FlixBus, arrive at Florence Villa Constanza Bus Station.
Milan to Isernia train services, operated by Trenitalia Frecce, arrive at Roma Termini station.
Yes, the driving distance between Milan to Isernia is 726 km. It takes approximately 6h 44m to drive from Milan to Isernia.
Book your Milan to Isernia train tickets online with Omio.
Book your Milan to Isernia bus tickets online with Omio and FlixBus.
There are 424+ hotels available in Isernia.
















































