There are 12 ways to get from Milan to Isernia by train, bus, car, plane, or train (Italo)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train
best- Take the train from Milan Rogoredo to Roma Terminitrain 9975 / ...
- Take the train from Roma Termini to Iserniatrain Re
6h 10mBus to Il Caravaggio International Airport, fly to Abruzzo Airport, bus
cheapest- Take the bus from Piazza Luigi di Savoia to Milan Bergamo Orio al Serio Airportbus
- Fly from Il Caravaggio International Airport (BGY) to Abruzzo Airport (PSR)plane BGY - PSR
- Take the bus from Pescara to Iserniabus
7h 47m€54–230Bus
- Take the bus from Milano, San Donato M3 to San Salvo Marinabus N424
- Take the bus from San Salvo Marina to Iserniabus Termoli-Rome tiburtina
10h 51mDrive 725.6 km
- Drive from Milan to Iserniacar 725.6 km
6h 44m€112–162Fly Milan Linate Airport to Fiumicino International Airport, train
- Fly from Milan Linate Airport (LIN) to Fiumicino International Airport (FCO)plane LIN - FCO
- Take the train from Roma Termini to Iserniatrain
6h 12mTrain via Milano Centrale
- Take the train from Milano Centrale to Roma Terminitrain 9981 / ...
- Take the train from Roma Termini to Iserniatrain Re
6h 13mTrain via Milan Centrale
- Take the train from Milano Centrale to Roma Terminitrain Fr / ...
- Take the train from Roma Termini to Iserniatrain Re
6h 20mFly Milan Linate Airport to Naples Airport, train
- Fly from Milan Linate Airport (LIN) to Naples Airport (NAP)plane LIN - NAP
- Take the train from Caserta to Iserniatrain
6h 20mFly Milan Linate Airport to Foggia Gino Lisa Airport, bus
- Fly from Milan Linate Airport (LIN) to Foggia Gino Lisa Airport (FOG)plane LIN - FOG
- Take the bus from Foggia to Iserniabus
6h 27mTrain to Milano Malpensa Airport, fly to Naples Airport, train
- Take the train from Milano Porta Garibaldi to Malpensa Aeroporto T1train
- Fly from Milano Malpensa Airport (MXP) to Naples Airport (NAP)plane MXP - NAP
- Take the train from Caserta to Iserniatrain
6h 56mBus to Il Caravaggio International Airport, fly to Naples Airport, train
- Take the bus from Piazza Luigi di Savoia to Milan Bergamo Orio al Serio Airportbus
- Fly from Il Caravaggio International Airport (BGY) to Naples Airport (NAP)plane BGY - NAP
- Take the train from Caserta to Iserniatrain
7h 3mTrain to Milano Malpensa Airport, fly to Abruzzo Airport, bus
- Take the train from Milano Porta Garibaldi to Malpensa Aeroporto T1train
- Fly from Milano Malpensa Airport (MXP) to Abruzzo Airport (PSR)plane MXP - PSR
- Take the bus from Pescara to Iserniabus
7h 50m
Milan Linate Airport (LIN) to Fiumicino International Airport (FCO) flights
Questions & Answers
The cheapest way to get from Milan to Isernia is to bus and fly which costs €50 - €230 and takes 7h 47m.
The fastest way to get from Milan to Isernia is to drive which takes 6h 44m and costs €110 - €170.
No, there is no direct bus from Milan to Isernia. However, there are services departing from Milano, San Donato M3 and arriving at Isernia via San Salvo Marina. The journey, including transfers, takes approximately 10h 51m.
No, there is no direct train from Milan to Isernia. However, there are services departing from Milan Rogoredo and arriving at Isernia via Roma Termini. The journey, including transfers, takes approximately 6h 10m.
The distance between Milan and Isernia is 739 km. The road distance is 725.6 km.
The best way to get from Milan to Isernia without a car is to train which takes 6h 10m and costs .
It takes approximately 6h 10m to get from Milan to Isernia, including transfers.
Milan to Isernia bus services, operated by FlixBus-eu, depart from Milano, San Donato M3 station.
Milan to Isernia train services, operated by ItaloTreno, depart from Milan Rogoredo station.
The best way to get from Milan to Isernia is to train which takes 6h 10m and costs . Alternatively, you can bus, which costs and takes 10h 51m.
What companies run services between Milan, Italy and Isernia, Italy?
You can take a train from Milan Rogoredo to Isernia via Roma Termini in around 6h 10m. Alternatively, you can take a bus from Milano, San Donato M3 to Isernia via San Salvo Marina in around 10h 51m.
- Website
- ryanair.com
Flights from Milano Malpensa Airport to Naples Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €30–130
Flights from Il Caravaggio International Airport to Naples Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €40–160
Flights from Il Caravaggio International Airport to Naples Airport via Palermo
- Ave. Duration
- 3h 40m
- When
- Tuesday
- Estimated price
- €40–160
Flights from Milano Malpensa Airport to Abruzzo Airport
- Ave. Duration
- 1h 20m
- When
- Monday, Tuesday, Wednesday, Friday, Saturday, and Sunday
- Estimated price
- €25–130
Flights from Il Caravaggio International Airport to Abruzzo Airport
- Ave. Duration
- 1h 11m
- When
- Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €40–190
- Website
- ita-airways.com
Flights from Milan Linate Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €45–140
Flights from Milan Linate Airport to Naples Airport
- Ave. Duration
- 1h 24m
- When
- Every day
- Estimated price
- €40–130
Flights from Milan Linate Airport to Naples Airport via Fiumicino International Airport
- Ave. Duration
- 3h 18m
- When
- Every day
- Estimated price
- €40–130
- Website
- easyjet.com
Flights from Milano Malpensa Airport to Naples Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €24–120
- Website
- aeroitalia.com
Flights from Milan Linate Airport to Fiumicino International Airport via Olbia
- Ave. Duration
- 3h
- When
- Every day
- Estimated price
- €95–370
Flights from Milan Linate Airport to Foggia Gino Lisa Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €65–400
- Website
- flexflight.dk
Flights from Milan Linate Airport to Fiumicino International Airport via Olbia
- Ave. Duration
- 3h
- When
- Every day
- Estimated price
- €95–370
Flights from Milan Linate Airport to Foggia Gino Lisa Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €65–400
- Website
- flyulendo.com
Flights from Milano Malpensa Airport to Naples Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €30–140
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Milan Rogoredo to Roma Termini
- Ave. Duration
- 3h 2m
- Frequency
- Once daily
- Estimated price
- €75–150
- Website
- https://www.italotreno.it/en
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 44m
- Frequency
- 5 times a day
- Estimated price
- €75–150
- Website
- https://www.italotreno.it/en
- Website
- fsitaliane.it
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Schedules at
- fsitaliane.it
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 12m
- Frequency
- Hourly
- Schedules at
- fsitaliane.it
Train from Caserta to Isernia
- Ave. Duration
- 1h 18m
- Frequency
- 5 times a day
- Schedules at
- fsitaliane.it
- Website
- italotreno.com
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 5m
- Frequency
- Every 30 minutes
- Schedules at
- italotreno.com
- Website
- trenord.it
Train from Milano Porta Garibaldi to Malpensa Aeroporto T1
- Ave. Duration
- 43 min
- Frequency
- Every 30 minutes
- Schedules at
- trenord.it
- Website
- global.flixbus.com
Bus from Milano, San Donato M3 to San Salvo Marina
- Ave. Duration
- 8h 39m
- Frequency
- Once daily
- Schedules at
- global.flixbus.com
Bus from Foggia to Isernia
- Ave. Duration
- 2h 9m
- Frequency
- Once daily
- Schedules at
- global.flixbus.com
Bus from Pescara to Isernia
- Ave. Duration
- 2h 29m
- Frequency
- Once daily
- Schedules at
- global.flixbus.com
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from San Salvo Marina to Isernia
- Ave. Duration
- 1h 12m
- Frequency
- Once a week
- Estimated price
- €4–6
- Schedules at
- atm-molise.it
Bus from Pescara to Isernia
- Ave. Duration
- 2h 15m
- Frequency
- Twice daily
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
- customerservices@terravision.eu
- Website
- terravision.eu
Bus from Piazza Luigi di Savoia to Milan Bergamo Orio al Serio Airport
- Ave. Duration
- 50 min
- Frequency
- Every 30 minutes
- Estimated price
- €5–25
- Website
- https://www.terravision.eu/
Want to know more about travelling around Italy
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More Questions & Answers
Milan to Isernia bus services, operated by FlixBus-eu, arrive at San Salvo Marina station.
Milan to Isernia train services, operated by ItaloTreno, arrive at Roma Termini station.
Yes, the driving distance between Milan to Isernia is 726 km. It takes approximately 6h 44m to drive from Milan to Isernia.
Book your Milan to Isernia train tickets online with Omio.
There are 438+ hotels available in Isernia.

















