The train between Isernia and Siena takes 6h 3m. There is at least one train per day from Isernia to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run once daily between Isernia and Siena. The earliest departure is at 6:35 AM in the morning, and the last departure from Isernia is at 6:35 AM which arrives into Siena at 12:38 PM. All services require a transfer at Roma Termini and take an average of 6h 3m. The schedules shown below are for the next available departures.
Want to know about travelling from Isernia to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Siena. However, there are services departing from Isernia station and arriving at Siena station via Roma Termini. The journey, including transfers, takes approximately 6h 3m.
Isernia to Siena train services, operated by Trenitalia, depart from Isernia station.
Isernia to Siena train services, operated by Trenitalia, arrive at Siena station.
Book your Isernia to Siena train tickets online with Trenitalia and Trenitalia Frecce.
The distance between Isernia and Siena is 305.6 km. The road distance is 540 km.
You can take a train from Isernia to Siena via Roma Termini and Firenze S.M.N. in around 6h 40m.
