The average train between Isernia and Spoleto takes 5h 51m and the fastest train takes 4h 25m. The train service runs several times per day from Isernia to Spoleto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Isernia and Spoleto. The earliest departure is at 6:35 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Spoleto at 7:16 AM. All services require a transfer, and take on average 5h 51m. The schedules shown below are for the next available departures.

4h 27m • 1 change

5h 13m • 1 change

4h 38m • 1 change
Arrives next day

10h 41m • 1 change

4h 27m • 1 change

5h 13m • 1 change

4h 38m • 1 change
Arrives next day

10h 41m • 1 change

4h 27m • 1 change

5h 13m • 1 change

4h 38m • 1 change

4h 48m • 1 change

4h 27m • 1 change

5h 13m • 1 change

4h 38m • 1 change

4h 48m • 1 change
Want to know about travelling from Isernia to Spoleto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Spoleto. However, there are services departing from Isernia station and arriving at Spoleto station via Roma Termini. The journey, including transfers, takes approximately 5h 51m.
Isernia to Spoleto train services, operated by Trenitalia, depart from Isernia station.
Isernia to Spoleto train services, operated by Trenitalia, arrive at Spoleto station.
Book your Isernia to Spoleto train tickets online with Trenitalia.
The distance between Isernia and Spoleto is 177.1 km. The road distance is 310 km.
You can take a train from Isernia to Spoleto via Roma Termini in around 4h 35m.