Train Isernia to Spoleto from €46 | Tickets & Timetables

Trip Overview

The average train between Isernia and Spoleto takes 5h 45m and the fastest train takes 4h 1m. The train service runs several times per day from Isernia to Spoleto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 45m
Duration: 310 km
Distance: €46
Average price: 5 times a day
Frequency

Train (Trenitalia)

best

Take the train from Isernia to Roma Terminitrain Re
Take the train from Roma Termini to Spoletotrain 4150 / ...

4h 4m

€36–77

Isernia to Spoleto train times

Trains run 5 times a day between Isernia and Spoleto. The earliest departure is at 6:40 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Spoleto at 7:16 AM. All services require a transfer, and take on average 5h 45m. The schedules shown below are for the next available departures.

Departing Tuesday, July 7, 2026

6:00 PM → 10:48 PM
4h 48m • 1 change
8:35 PM → 7:16 AM
Arrives next day
10h 41m • 1 change

Departing Wednesday, July 8, 2026

6:40 AM → 11:02 AM
4h 22m • 1 change
8:38 AM → 1:51 PM
5h 13m • 1 change
3:03 PM → 7:41 PM
4h 38m • 1 change
6:00 PM → 10:48 PM
4h 48m • 1 change
Show more

Departing Thursday, July 9, 2026

6:40 AM → 11:02 AM
4h 22m • 1 change
8:38 AM → 1:51 PM
5h 13m • 1 change
3:03 PM → 7:41 PM
4h 38m • 1 change
6:00 PM → 10:48 PM
4h 48m • 1 change
Show more

Departing Friday, July 10, 2026

6:40 AM → 11:02 AM
4h 22m • 1 change
8:38 AM → 1:51 PM
5h 13m • 1 change
3:03 PM → 7:41 PM
4h 38m • 1 change
6:00 PM → 10:48 PM
4h 48m • 1 change
Show more

Departing Saturday, July 11, 2026

6:40 AM → 11:02 AM
4h 22m • 1 change
8:38 AM → 1:51 PM
5h 13m • 1 change
3:03 PM → 8:03 PM
5h • 1 change
6:00 PM → 10:48 PM
4h 48m • 1 change
Show more

Departing Sunday, July 12, 2026

6:40 AM → 11:00 AM
4h 20m • 1 change
8:38 AM → 1:03 PM
4h 25m • 1 change
3:19 PM → 7:41 PM
4h 22m • 1 change
5:27 PM → 9:28 PM
4h 1m • 1 change
Show more

Departing Monday, July 13, 2026

6:40 AM → 11:02 AM
4h 22m • 1 change
8:38 AM → 1:51 PM
5h 13m • 1 change
3:03 PM → 7:41 PM
4h 38m • 1 change
6:00 PM → 10:48 PM
4h 48m • 1 change

Frequently asked questions

Want to know about travelling from Isernia to Spoleto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.