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How to get fromIsernia to Brusselsby train, plane, train (Trenitalia, Eurostar), bus, night train, car or car train

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There are 11 ways to get from Isernia to Brussels by train, plane, train (Trenitalia, Eurostar), bus, night train, car, or car train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Naples Airport, fly to Brussels Airport

    best
    1. Take the train from Isernia to Napoli Centraletrain train
    2. Fly from Naples Airport (NAP) to Brussels Airport (BRU)plane plane NAP - BRU
    7h 6m
    €88–208

  2. Train to Fiumicino International Airport, fly to Brussels Airport

    cheapest
    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Brussels Airport (BRU)plane plane FCO - BRU
    7h 38m
    €63–215

  3. Train

    1. Take the train from Isernia to Roma Terminitrain train Re
    2. Take the train from Roma Termini to Milano Centraletrain train Fr / ...
    3. Take the train from Milano Centrale to Paris Gare De Lyontrain train Fr
    4. Take the train from Paris Nord to Brussel-Zuid / Bruxelles-Miditrain train
    15h 29m
    €148–519

  4. Bus

    1. Take the bus from Isernia to Termoli Terminal Busbus bus
    2. Take the bus from Termoli to Frankfurtbus bus
    3. Take the bus from Frankfurt to Brusselsbus bus
    23h 38m
    €113–140

  5. Train, night train

    1. Take the train from Isernia to Roma Tiburtinatrain train Re
    2. Take the night train from Roma Tiburtina to Rosenheimnighttrain night train En
    3. Take the night train from Rosenheim to Brussels-Nordnighttrain night train Nj
    30h 2m
    €268–564

  6. Train to Naples Airport, fly to Brussels South Charleroi Airport, bus

    1. Take the train from Isernia to Napoli Centraletrain train
    2. Fly from Naples Airport (NAP) to Brussels South Charleroi Airport (CRL)plane plane NAP - CRL
    3. Take the bus from Charleroi Airport to Brussels Midi / Brussels South Westbus bus
    7h 43m
    €91–248

  7. Train to Roma Ciampino Airport, fly to Brussels South Charleroi Airport, bus

    1. Take the train from Isernia to Ciampinotrain train
    2. Fly from Roma Ciampino Airport (CIA) to Brussels South Charleroi Airport (CRL)plane plane CIA - CRL
    3. Take the bus from Charleroi Airport to Brussels Midi / Brussels South Westbus bus
    7h 59m
    €75–257

  8. Train to Naples Airport, fly to Amsterdam Airport Schiphol, train

    1. Take the train from Isernia to Napoli Centraletrain train
    2. Fly from Naples Airport (NAP) to Amsterdam Airport Schiphol (AMS)plane plane NAP - AMS
    3. Take the train from Schiphol Airport to Brussel-Zuidtrain train
    9h 5m
    €109–378

  9. Bus via Bologna

    1. Take the bus from Isernia to Bologna Centralebus bus 433
    2. Take the bus from Bologna to Brussels-North Stationbus bus
    30h 22m

  10. Drive 1,580.7 km

    1. Drive from Isernia to Brusselscar car 1,580.7 km
    16h 11m
    €242–350

  11. Drive, car train

    1. Drive from Isernia to Villach Hbfcar car
    2. Take the car train from Villach Hbf to Düsseldorf Hbfcartrain train
    3. Drive from Düsseldorf Hbf to Brusselscar car
    18h 1m
    €260–1,233

Isernia to Brussels by train

Calendar14Weekly Trains
Duration15h 29mAverage Duration
Ticket€148Cheapest Price
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Questions & Answers

What companies run services between Isernia, Italy and Brussels, Belgium?

You can take a train from Isernia to Brussel-Zuid / Bruxelles-Midi via Roma Termini, Milano Centrale, Paris Gare de Lyon, and Paris Nord in around 15h 29m. Alternatively, you can take a bus from Isernia to Brussels via Termoli, Frankfurt, and Frankfurt in around 23h 38m.

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