The average train between Arezzo and Isernia takes 7h 11m and the fastest train takes 4h 42m. The train service runs several times per day from Arezzo to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Arezzo and Isernia. The earliest departure is at 6:33 AM in the morning, and the last departure from Arezzo is at 10:17 PM which arrives into Isernia at 8:27 AM. All services require a transfer, and take on average 7h 11m. The schedules shown below are for the next available departures.

8h 50m • 1 change

5h 38m • 1 change

6h 6m • 1 change
Arrives next day

12h 10m • 1 change

4h 42m • 1 change

7h 33m • 1 change

6h 9m • 1 change
Arrives next day

10h 10m • 1 change

4h 42m • 1 change

7h 33m • 1 change

6h 9m • 1 change
Arrives next day

10h 10m • 1 change

4h 42m • 1 change

7h 33m • 1 change

6h 9m • 1 change
Arrives next day

10h 10m • 1 change

4h 42m • 1 change

7h 33m • 1 change

6h 9m • 1 change
Arrives next day

10h 10m • 1 change
Want to know about travelling from Arezzo to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Arezzo to Isernia. However, there are services departing from Arezzo station and arriving at Isernia station via Roma Termini. The journey, including transfers, takes approximately 7h 11m.
Arezzo to Isernia train services, operated by Trenitalia Frecce, depart from Arezzo station.
Arezzo to Isernia train services, operated by Trenitalia Frecce, arrive at Isernia station.
Book your Arezzo to Isernia train tickets online with Trenitalia Frecce and Trenitalia.
The distance between Arezzo and Isernia is 283.3 km. The road distance is 399 km.
You can take a train from Arezzo to Isernia via Roma Termini in around 5h 56m.