There are 5 ways to get from Ancona to Isernia by train, bus, car, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train, bus via Pescara
best- Take the train from Ancona to Pescara CentraleFr
- Take the bus from Pescara to IserniaCb 011
4h 23m€17–58Train, bus
- Take the train from Ancona to TermoliFr
- Take the bus from Termoli Terminal Bus to IserniaCb 014 / ...
4h 44m€30–59Drive 293 km
- Drive from Ancona to Isernia293 km
3h 27m€46–67Bus
- Take the bus from Ancona to Isernia433
4h 54m€24–35Train
- Take the train from Ancona to Roma Termini4157 / ...
- Take the train from Roma Termini to IserniaRe
6h 57m€27–101
Ancona to Isernia by train and bus
Questions & Answers
The cheapest way to get from Ancona to Isernia is to bus which costs €24 - €35 and takes 4h 54m.
The fastest way to get from Ancona to Isernia is to drive which takes 3h 27m and costs €45 - €70.
Yes, there is a direct bus departing from Ancona and arriving at Isernia. Services depart once daily, and operate every day. The journey takes approximately 4h 54m.
No, there is no direct train from Ancona to Isernia. However, there are services departing from Ancona and arriving at Isernia via Roma Termini. The journey, including transfers, takes approximately 6h 57m.
The distance between Ancona and Isernia is 320 km. The road distance is 293 km.
The best way to get from Ancona to Isernia without a car is to train and bus via Pescara which takes 4h 23m and costs €17 - €60.
It takes approximately 4h 23m to get from Ancona to Isernia, including transfers.
Ancona to Isernia bus services, operated by FlixBus, depart from Ancona station.
Ancona to Isernia train services, operated by Trenitalia S.p.A., depart from Ancona station.
The best way to get from Ancona to Isernia is to bus which takes 4h 54m and costs €24 - €35. Alternatively, you can train, which costs €26 - €110 and takes 6h 57m.
What companies run services between Ancona, Italy and Isernia, Italy?
FlixBus operates a bus from Ancona to Isernia once daily. Tickets cost €24–35 and the journey takes 4h 54m. Alternatively, you can take a train from Ancona to Isernia via Roma Termini in around 6h 57m.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Ancona to Pescara Centrale
- Ave. Duration
- 1h 8m
- Frequency
- Hourly
- Estimated price
- €14–30
- Schedules at
- trenitalia.com
Train from Ancona to Termoli
- Ave. Duration
- 1h 58m
- Frequency
- Every 2 hours
- Estimated price
- €35–55
- Schedules at
- trenitalia.com
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Ancona to Pescara Centrale
- Ave. Duration
- 1h 22m
- Frequency
- Every 3 hours
- Estimated price
- €12–18
- Website
- https://www.trenitalia.com/en.html
Train from Ancona to Termoli
- Ave. Duration
- 2h 13m
- Frequency
- Every 4 hours
- Estimated price
- €24–28
- Website
- https://www.trenitalia.com/en.html
Train from Ancona to Roma Termini
- Ave. Duration
- 4h 4m
- Frequency
- Twice daily
- Estimated price
- €15–70
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Ancona to Pescara Centrale
- Ave. Duration
- 2h 9m
- Frequency
- Every 3 hours
- Estimated price
- €9–27
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €19–27
Train from Ancona to Roma Termini
- Ave. Duration
- 3h 45m
- Frequency
- 5 times a day
- Estimated price
- €23–45
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 12m
- Frequency
- Every 4 hours
- Estimated price
- €11–35
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €24–35
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Pescara to Isernia
- Ave. Duration
- 2h 15m
- Frequency
- Twice daily
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Bus from Termoli Terminal Bus to Isernia
- Ave. Duration
- 1h 35m
- Frequency
- Once a week
- Estimated price
- €5–8
- Schedules at
- atm-molise.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Pescara to Isernia
- Ave. Duration
- 2h 29m
- Frequency
- Once daily
- Estimated price
- €16–28
- Website
- https://www.flixbus.co.uk
Bus from Ancona to Isernia
- Ave. Duration
- 4h 54m
- Frequency
- Once daily
- Estimated price
- €24–35
- Website
- https://www.flixbus.co.uk
Want to know more about travelling around Italy
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
Want to know more about Flixbus?
Read the travel guide
More Questions & Answers
Ancona to Isernia bus services, operated by FlixBus, arrive at Isernia station.
Ancona to Isernia train services, operated by Trenitalia S.p.A., arrive at Roma Termini station.
Yes, the driving distance between Ancona to Isernia is 293 km. It takes approximately 3h 27m to drive from Ancona to Isernia.
Book your Ancona to Isernia bus tickets online with Omio and FlixBus.
There are 417+ hotels available in Isernia.


















