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Key West to Lake Charles buses

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Trip Overview

The bus between Key West and Lake Charles takes 41h 10m. The bus runs, on average, 5 times per week from Key West to Lake Charles. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

41h 10m
Duration
1,577 mi
Distance
$315
Average price
5 times a week
Frequency

Key West to Lake Charles bus times

Buses run 5 times a week between Key West and Lake Charles. The service departs Key West at 4:15 PM in the afternoon, which arrives into Lake Charles at 08:25:00. All services require a transfer at Big Pine Key - Auto Store / NAPA MM30 and take an average of 41h 10m. The schedules shown below are for the next available departures.

Departing Wednesday, November 4, 2026

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    Arrives +2 days

    Key West TransitGreyhound USAGreyhound USAGreyhound USA41h 10m • 3 changes

Departing Thursday, November 5, 2026

  •  → 

    Arrives +2 days

    Key West TransitGreyhound USAGreyhound USAGreyhound USA41h 10m • 3 changes

Departing Friday, November 6, 2026

  •  → 

    Arrives +2 days

    Key West TransitGreyhound USAGreyhound USAGreyhound USA41h 10m • 3 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives +2 days

    Key West TransitGreyhound USAGreyhound USAGreyhound USA41h 10m • 3 changes

Departing Sunday, November 8, 2026

  •  → 

    Arrives +2 days

    Key West TransitGreyhound USAGreyhound USAGreyhound USA41h 10m • 3 changes

Frequently asked questions

Want to know about travelling from Key West to Lake Charles? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Key West to Lake Charles.ExpandLaunch map view
  • Distance: 1,576.8 mi
  • Duration: 41h 10m

What companies run services between Key West, FL, USA and Lake Charles, LA, USA?

You can take a bus from N Roosevelt & 3rd Street to Lake Charles via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Atlanta Bus Station, Garnett Station, Doraville Station, and Atlanta in around 31h 25m.

Operators