The average bus between Key West and Mississippi takes 34h 22m and the fastest bus takes 29h 41m. The bus service runs several times per day from Key West to Mississippi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Key West and Mississippi. The earliest departure is at 7:39 AM in the morning, and the last departure from Key West is at 4:15 PM which arrives into Mississippi at 7:15 AM. All services require a transfer at Big Pine Key - Auto Store / NAPA MM30 and take an average of 34h 22m. The schedules shown below are for the next available departures.
Arrives next day



28h 41m • 3 changes
Arrives +2 days



39h • 3 changes
Arrives next day



28h 41m • 3 changes
Arrives +2 days



39h • 3 changes
Arrives next day



28h 41m • 3 changes
Arrives +2 days



39h • 3 changes
Arrives next day



28h 41m • 3 changes
Arrives +2 days



39h • 3 changes
Want to know about travelling from Key West to Mississippi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Key West to Mississippi. However, there are services departing from Key West station and arriving at Mississippi station via Big Pine Key - Auto Store / NAPA MM30. The journey, including transfers, takes approximately 34h 22m.
Key West to Mississippi bus services, operated by Key West Transit, depart from N Roosevelt & 3rd Street station.
Key West to Mississippi bus services, operated by Key West Transit, arrive at Jackson station.
The distance between Key West and Mississippi is 1,214.3 km. The road distance is 1,966 km.
You can take a bus from N Roosevelt & 3rd Street to Jackson via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, and Atlanta Bus Station in around 28h 32m.