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Key West to Orlando buses

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Trip Overview

The average bus between Key West and Orlando takes 12h 13m and the fastest bus takes 10h 38m. The bus service runs several times per day from Key West to Orlando. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

12h 13m
Duration
388 mi
Distance
$78
Average price
Twice daily
Frequency

Key West to Orlando bus times

Buses run twice daily between Key West and Orlando. The earliest departure is at 7:39 AM in the morning, and the last departure from Key West is at 4:15 PM which arrives into Orlando at 5:37 AM. All services require a transfer at Big Pine Key - Auto Store / NAPA MM30 and take an average of 12h 13m. The schedules shown below are for the next available departures.

Departing Saturday, November 14, 2026

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    Key West TransitGreyhound USAFlixbus USALynx Central Florida Transport10h 42m • 3 changes
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    Arrives next day

    Key West TransitGreyhound USAFlixbus USALynx Central Florida Transport13h 22m • 3 changes

Departing Sunday, November 15, 2026

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    Key West TransitGreyhound USAFlixbus USALynx Central Florida Transport10h 38m • 3 changes
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    Arrives next day

    Key West TransitGreyhound USAFlixbus USALynx Central Florida Transport12h 48m • 3 changes

Departing Monday, November 16, 2026

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    Key West TransitGreyhound USAFlixbus USALynx Central Florida Transport10h 47m • 3 changes
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    Arrives next day

    Key West TransitGreyhound USAFlixbus USALynx Central Florida Transport12h 48m • 3 changes

Departing Tuesday, November 17, 2026

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    Key West TransitGreyhound USAFlixbus USALynx Central Florida Transport10h 47m • 3 changes
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    Arrives next day

    Key West TransitGreyhound USAFlixbus USALynx Central Florida Transport12h 48m • 3 changes

Departing Wednesday, November 18, 2026

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    Key West TransitGreyhound USAFlixbus USALynx Central Florida Transport15h 30m • 3 changes
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    Arrives next day

    Key West TransitGreyhound USAFlixbus USALynx Central Florida Transport12h 48m • 3 changes

Departing Thursday, November 19, 2026

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    Arrives next day

    Key West TransitGreyhound USAFlixbus USALynx Central Florida Transport12h 48m • 3 changes

Departing Friday, November 20, 2026

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    Key West TransitGreyhound USAFlixbus USALynx Central Florida Transport10h 47m • 3 changes

Frequently asked questions

Want to know about travelling from Key West to Orlando? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Key West to Orlando.ExpandLaunch map view
  • Distance: 388.4 mi
  • Duration: 12h 13m

What companies run services between Key West, FL, USA and Orlando, FL, USA?

You can take a bus from N Roosevelt & 3rd Street to Mccoy Rd & Central Ave via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Orlando, and Florida Mall in around 11h 11m.

Operators