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Key Largo to Lake Charles buses

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Trip Overview

The bus between Key Largo and Lake Charles takes 37h 25m. The bus runs, on average, 6 times per week from Key Largo to Lake Charles. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

37h 25m
Duration
1,151 mi
Distance
$284
Average price
6 times a week
Frequency

Key Largo to Lake Charles bus times

Buses run 6 times a week between Key Largo and Lake Charles. The service departs Key Largo at 8:00 PM in the evening, which arrives into Lake Charles at 08:25:00. All services require a transfer at Miami, Airport Intermodal Station and take an average of 37h 25m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA37h 25m • 2 changes

Departing Thursday, November 12, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA37h 25m • 2 changes

Departing Friday, November 13, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA37h 25m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA37h 25m • 2 changes

Departing Sunday, November 15, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA37h 25m • 2 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA37h 25m • 2 changes

Frequently asked questions

Want to know about travelling from Key Largo to Lake Charles? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Key Largo to Lake Charles.ExpandLaunch map view
  • Distance: 1,151.3 mi
  • Duration: 37h 25m

What companies run services between Key Largo, FL, USA and Lake Charles, LA, USA?

You can take a bus from Key Largo Bus Stop to Lake Charles via Miami, Airport Intermodal Station, Miami Airport Station, Miami International Airport, Miami Airport, Old St Augustine at Intramural Field, and Tallahassee in around 26h.

Operators