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Key West to Fort Myers buses

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Trip Overview

The average bus between Key West and Fort Myers takes 14h 48m and the fastest bus takes 11h 6m. The bus service runs several times per day from Key West to Fort Myers. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

14h 48m
Duration
324 mi
Distance
$66
Average price
Twice daily
Frequency

Key West to Fort Myers bus times

Buses run twice daily between Key West and Fort Myers. The earliest departure is at 7:39 AM in the morning, and the last departure from Key West is at 4:15 PM which arrives into Fort Myers at 10:45 AM. All services require a transfer at Big Pine Key - Auto Store / NAPA MM30 and take an average of 14h 48m. The schedules shown below are for the next available departures.

Departing Sunday, November 15, 2026

  •  → 

    Key West TransitGreyhound USAFlixbus USA11h 6m • 2 changes
  •  → 

    Arrives next day

    Key West TransitGreyhound USAFlixbus USA18h 30m • 2 changes

Departing Monday, November 16, 2026

  •  → 

    Key West TransitGreyhound USAFlixbus USA11h 6m • 2 changes
  •  → 

    Arrives next day

    Key West TransitGreyhound USAFlixbus USA18h 30m • 2 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives next day

    Key West TransitGreyhound USAFlixbus USA18h 30m • 2 changes

Departing Wednesday, November 18, 2026

  •  → 

    Key West TransitGreyhound USAFlixbus USA11h 6m • 2 changes
  •  → 

    Arrives next day

    Key West TransitGreyhound USAFlixbus USA18h 30m • 2 changes

Departing Thursday, November 19, 2026

  •  → 

    Key West TransitGreyhound USAFlixbus USA11h 6m • 2 changes
  •  → 

    Arrives next day

    Key West TransitGreyhound USAFlixbus USA18h 30m • 2 changes

Departing Friday, November 20, 2026

  •  → 

    Key West TransitGreyhound USAFlixbus USA11h 6m • 2 changes
  •  → 

    Arrives next day

    Key West TransitGreyhound USAFlixbus USA18h 30m • 2 changes

Departing Saturday, November 21, 2026

  •  → 

    Key West TransitGreyhound USAFlixbus USA11h 6m • 2 changes

Frequently asked questions

Want to know about travelling from Key West to Fort Myers? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Key West to Fort Myers.ExpandLaunch map view
  • Distance: 324 mi
  • Duration: 14h 48m

What companies run services between Key West, FL, USA and Fort Myers, FL, USA?

You can take a bus from N Roosevelt & 3rd Street to Fort Myers Bus Stop via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, and Miami Airport Station in around 9h 52m.

Operators