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Key West to Estero buses

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Trip Overview

The average bus between Key West and Estero takes 17h 24m and the fastest bus takes 13h. The bus service runs several times per day from Key West to Estero. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

17h 24m
Duration
341 mi
Distance
$67
Average price
Twice daily
Frequency

Key West to Estero bus times

Buses run twice daily between Key West and Estero. The earliest departure is at 7:39 AM in the morning, and the last departure from Key West is at 4:15 PM which arrives into Estero at 12:33 PM. All services require a transfer at Big Pine Key - Auto Store / NAPA MM30 and take an average of 17h 24m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

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    Key West TransitGreyhound USAFlixbus USALee County TransitLee County Transit13h • 4 changes
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    Arrives next day

    Key West TransitGreyhound USAFlixbus USALee County TransitLee County Transit20h 18m • 4 changes

Departing Friday, November 13, 2026

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    Key West TransitGreyhound USAFlixbus USALee County TransitLee County Transit13h • 4 changes
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    Arrives next day

    Key West TransitGreyhound USAFlixbus USALee County TransitLee County Transit20h 18m • 4 changes

Departing Saturday, November 14, 2026

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    Key West TransitGreyhound USAFlixbus USALee County TransitLee County Transit13h • 4 changes
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    Arrives next day

    Key West TransitGreyhound USAFlixbus USALee County TransitLee County Transit20h 38m • 4 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Key West TransitGreyhound USAFlixbus USALee County TransitLee County Transit21h 47m • 4 changes
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    Arrives next day

    Key West TransitGreyhound USAFlixbus USALee County TransitLee County Transit20h 18m • 4 changes

Departing Monday, November 16, 2026

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    Key West TransitGreyhound USAFlixbus USALee County TransitLee County Transit13h • 4 changes
  •  → 

    Arrives next day

    Key West TransitGreyhound USAFlixbus USALee County TransitLee County Transit20h 18m • 4 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives next day

    Key West TransitGreyhound USAFlixbus USALee County TransitLee County Transit20h 18m • 4 changes

Departing Wednesday, November 18, 2026

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    Key West TransitGreyhound USAFlixbus USALee County TransitLee County Transit13h • 4 changes

Frequently asked questions

Want to know about travelling from Key West to Estero? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Key West to Estero.ExpandLaunch map view
  • Distance: 341 mi
  • Duration: 17h 24m

What companies run services between Key West, FL, USA and Estero, FL, USA?

You can take a bus from N Roosevelt & 3rd Street to S Tamiami Trl @ Lychee Ln via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Rosa Parks Transportation Ctr, and South Fort Myers Transfer/P&R in around 12h 3m.

Operators