The average train between Prague and Mainz takes 9h 11m and the fastest train takes 8h 9m. The train service runs several times per day from Prague to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Prague and Mainz. The earliest departure is at 5:35 AM in the morning, and the last departure from Prague is at 5:35 PM which arrives into Mainz at 8:22 AM. All services require a transfer at Schwandorf and take an average of 9h 11m. The schedules shown below are for the next available departures.



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9h 9m • 3 changesWant to know about travelling from Prague to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prague to Mainz. However, there are services departing from Prague station and arriving at Mainz station via Schwandorf. The journey, including transfers, takes approximately 9h 11m.
Prague to Mainz train services, operated by ÖBB EuroCity, depart from Praha Hlavni Nadrazi station.
Prague to Mainz train services, operated by ÖBB EuroCity, arrive at Frankfurt station.
Book your Prague to Mainz train tickets online with ÖBB EuroCity, Deutsche Bahn Regio (DB Regional) and 3 other operators.
The distance between Prague and Mainz is 438.7 km. The road distance is 603 km.
You can take a train from Praha Hlavni Nadrazi to Mainz, Römisches Theater via Schwandorf, Nürnberg Hbf, and Frankfurt in around 9h 5m.