The average train between Prague and Mainz takes 9h 58m and the fastest train takes 8h 41m. The train service runs several times per day from Prague to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Prague and Mainz. The earliest departure is at 6:41 AM in the morning, and the last departure from Prague is at 6:41 PM which arrives into Mainz at 11:22 AM. All services require a transfer at Dresden Bahnhof Neustadt and take an average of 9h 58m. The schedules shown below are for the next available departures.


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Want to know about travelling from Prague to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prague to Mainz. However, there are services departing from Prague station and arriving at Mainz station via Dresden-Neustadt. The journey, including transfers, takes approximately 9h 58m.
Prague to Mainz train services, operated by ÖBB EuroCity, depart from Praha-Holesovice station.
Prague to Mainz train services, operated by ÖBB EuroCity, arrive at Frankfurt station.
The distance between Prague and Mainz is 438.7 km. The road distance is 713 km.
You can take a train from Praha-Holesovice to Mainz, Römisches Theater via Dresden Bahnhof Neustadt and Frankfurt in around 8h 26m.