Prague to Mainz Trains

Trip Overview

The average train between Prague and Mainz takes 9h 29m and the fastest train takes 8h 11m. The train service runs several times per day from Prague to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

9h 29m
Duration: 713 km
Distance: €155
Average price: 5 times a day
Frequency

Train via Erfurt

best

Take the train from Praha-Holesovice to Dresden Hbftrain Rj
Take the train from Dresden Hauptbahnhof to Leipzig Hbftrain 55 / ...
Take the train from Leipzig Hbf to Erfurt Hbftrain 28 / ...
Take the train from Erfurt Hbf to Frankfurttrain 12 / ...

8h 3m

€101–317

Prague to Mainz train times

Trains run 5 times a day between Prague and Mainz. The earliest departure is at 6:41 AM in the morning, and the last departure from Prague is at 8:57 PM which arrives into Mainz at 9:23 AM. All services require a transfer at Dresden Hauptbahnhof and take an average of 9h 29m. The schedules shown below are for the next available departures.

Departing Friday, October 30, 2026

5:38 PM → 2:52 AM
Arrives next day
9h 14m • 4 changes
8:57 PM → 9:23 AM
Arrives next day
12h 26m • 4 changes

Departing Saturday, October 31, 2026

6:41 AM → 3:23 PM
8h 42m • 4 changes
8:41 AM → 5:23 PM
8h 42m • 4 changes
10:41 AM → 7:23 PM
8h 42m • 4 changes
12:41 PM → 9:23 PM
8h 42m • 4 changes
Show more

Departing Sunday, November 1, 2026

6:41 AM → 3:23 PM
8h 42m • 4 changes
8:41 AM → 5:23 PM
8h 42m • 4 changes
10:41 AM → 7:23 PM
8h 42m • 4 changes
12:41 PM → 9:23 PM
8h 42m • 4 changes
Show more

Departing Monday, November 2, 2026

6:41 AM → 3:22 PM
8h 41m • 4 changes
6:41 PM → 2:52 AM
Arrives next day
8h 11m • 4 changes
8:57 PM → 11:22 AM
Arrives next day
14h 25m • 4 changes

Departing Tuesday, November 3, 2026

6:41 AM → 3:22 PM
8h 41m • 4 changes
10:41 AM → 7:22 PM
8h 41m • 4 changes
6:41 PM → 2:52 AM
Arrives next day
8h 11m • 4 changes
8:57 PM → 11:22 AM
Arrives next day
14h 25m • 4 changes

Departing Wednesday, November 4, 2026

6:41 AM → 3:22 PM
8h 41m • 4 changes
10:41 AM → 7:22 PM
8h 41m • 4 changes
6:41 PM → 2:52 AM
Arrives next day
8h 11m • 4 changes
8:57 PM → 9:22 AM
Arrives next day
12h 25m • 4 changes

Departing Thursday, November 5, 2026

6:41 AM → 3:22 PM
8h 41m • 4 changes
10:41 AM → 7:22 PM
8h 41m • 4 changes

Frequently asked questions

Want to know about travelling from Prague to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

What companies run services between Prague, Czechia and Mainz, Germany?

You can take a train from Praha-Holesovice to Mainz, Römisches Theater via Dresden Hauptbahnhof, Leipzig Hbf, Erfurt Hbf, and Frankfurt in around 8h 3m.

Operators