There are 7 ways to get from Prague to Mainz by subway, plane, bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Subway to Václav Havel Airport Prague, fly
best- Take the subway from Staroměstská to Nádraží Veleslavínsubway
- Fly from Václav Havel Airport Prague (PRG) to Frankfurt (FRA)plane PRG - FRA
4h 2m€74–167Bus
cheapest- Take the bus from Prague to Mainz central train stationbus N1310
8h 5m€30–85Train via Dresden
- Take the train from Praha-Holesovice to Dresden Hbftrain Rj
- Take the train from Dresden Hauptbahnhof to Frankfurttrain 50
8h 23m€68–160Drive 539.5 km
- Drive from Prague to Mainzcar 539.5 km
4h 31m€83–120Train to Dresden Airport, fly
- Take the train from Praha-Holesovice to Dresden Hbftrain
- Fly from Dresden Airport (DRS) to Frankfurt (FRA)plane DRS - FRA
5h 28m€174–343Bus via Frankfurt am Main
- Take the bus from Prague Florenc Bus Station to Frankfurt am Mainbus
9h 40mTrain
- Take the train from Praha Hlavni Nadrazi to Frankfurt(Main)Suedtrain Ec
10h 5m€124–170
Prague to Mainz by bus
Questions & Answers
The cheapest way to get from Prague to Mainz is to bus which costs €30 - €85 and takes 8h 5m.
The fastest way to get from Prague to Mainz is to subway and fly which takes 4h 2m and costs €70 - €170.
Yes, there is a direct bus departing from Prague and arriving at Mainz central train station station. Services depart once daily, and operate every day. The journey takes approximately 8h 5m.
No, there is no direct train from Prague to Mainz. However, there are services departing from Praha-Holesovice and arriving at Mainz, Römisches Theater via Dresden Hauptbahnhof and Frankfurt. The journey, including transfers, takes approximately 8h 23m.
The distance between Prague and Mainz is 447 km. The road distance is 539.5 km.
The best way to get from Prague to Mainz without a car is to bus which takes 8h 5m and costs €30 - €85.
It takes approximately 4h 2m to get from Prague to Mainz, including transfers.
Prague to Mainz bus services, operated by FlixBus, depart from Prague station.
Prague to Mainz train services, operated by České dráhy (ČD), depart from Praha-Holesovice station.
The best way to get from Prague to Mainz is to bus which takes 8h 5m and costs €30 - €85. Alternatively, you can train via Dresden, which costs €65 - €160 and takes 8h 23m.
What companies run services between Prague, Czechia and Mainz, Germany?
FlixBus operates a bus from Prague to Mainz central train station once daily. Tickets cost €30–85 and the journey takes 8h 5m. Alternatively, you can take a train from Praha-Holesovice to Mainz, Römisches Theater via Dresden Hauptbahnhof and Frankfurt in around 8h 23m.
- Website
- lufthansa.com
Flights from Václav Havel Airport Prague to Frankfurt
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €80–270
Flights from Václav Havel Airport Prague to Frankfurt via Munich
- Ave. Duration
- 2h 45m
- When
- Monday, Tuesday, Friday, Saturday, and Sunday
- Estimated price
- €80–260
Flights from Dresden Airport to Frankfurt
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- €130–270
Flights from Dresden Airport to Frankfurt via Munich
- Ave. Duration
- 2h 50m
- When
- Monday, Wednesday, and Friday
- Estimated price
- €130–270
- Website
- condor.com
Flights from Václav Havel Airport Prague to Frankfurt
- Ave. Duration
- 1h 1m
- When
- Every day
- Estimated price
- €65–140
- Website
- airdolomiti.it
Flights from Václav Havel Airport Prague to Frankfurt
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €85–270
- Phone
- +420 234 704 560
- info@pid.cz
- Website
- pid.cz
Subway from Staroměstská to Nádraží Veleslavín
- Ave. Duration
- 9 min
- Frequency
- Every 10 minutes
- Estimated price
- €1–2
- Website
- https://pid.cz/en/
- Phone
- +420 221 111 122
- info@cd.cz
- Website
- cd.cz
Train from Praha-Holesovice to Dresden Hbf
- Ave. Duration
- 2h 9m
- Frequency
- Every 4 hours
- Estimated price
- €11–23
- Website
- https://www.cd.cz/en/default.htm
- 2nd Class
- €11–16
- 1st Class
- €17–23
- Business
- €19–21
Train from Praha-Holesovice to Dresden Hbf
- Ave. Duration
- 2h 9m
- Frequency
- Once daily
- Estimated price
- €30–45
- Website
- https://www.oebb.at/en/reiseplanung-services/im-zug/unsere-zuege/railjet
- *
- €30–45
- Phone
- +43 5 1717
- Website
- oebb.at
Train from Praha-Holesovice to Dresden Hbf
- Ave. Duration
- 2h 18m
- Frequency
- 5 times a week
- Estimated price
- €35–50
- Website
- https://www.oebb.at/en/reiseplanung-services/im-zug/unsere-zuege/eurocity-intercity
- Website
- https://shop.oebbtickets.at/en/ticket
Train from Praha Hlavni Nadrazi to Frankfurt(Main)Sued
- Ave. Duration
- 9h 4m
- Frequency
- 5 times a week
- Estimated price
- €110–150
- Website
- https://www.oebb.at/en/reiseplanung-services/im-zug/unsere-zuege/eurocity-intercity
- Website
- https://shop.oebbtickets.at/en/ticket
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Dresden Hauptbahnhof to Frankfurt
- Ave. Duration
- 4h 26m
- Frequency
- Every 4 hours
- Estimated price
- €30–95
- Website
- https://int.bahn.de/en
#/media/File:ICE_4_Berlin_Hauptbahnhof_(3).jpg "ICE 4 Berlin Hauptbahnhof")
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Prague to Mainz central train station
- Ave. Duration
- 8h 5m
- Frequency
- Once daily
- Estimated price
- €30–85
- Website
- https://www.flixbus.co.uk
- helpline.svs@gmail.com
- Website
- svs.md
Bus from Prague Florenc Bus Station to Frankfurt am Main
- Ave. Duration
- 8h 44m
- Frequency
- Once a week
- Website
- https://svs.md/en/bus/route/number-19167
Want to know more about travelling around Germany
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Heading to Europe? Read this before you buy a Eurail Pass
Read the travel guide
Want to know more about Flixbus?
Read the travel guide
More Questions & Answers
Prague to Mainz bus services, operated by FlixBus, arrive at Mainz central train station.
Prague to Mainz train services, operated by České dráhy (ČD), arrive at Dresden Hbf station.
Yes, the driving distance between Prague to Mainz is 540 km. It takes approximately 4h 31m to drive from Prague to Mainz.
Book your Prague to Mainz bus tickets online with Omio and FlixBus.
There are 1121+ hotels available in Mainz.