The average train between Mainz and Pisa takes 15h 21m and the fastest train takes 11h 50m. The train service runs several times per day from Mainz to Pisa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mainz and Pisa. The earliest departure is at 1:38 AM at night, and the last departure from Mainz is at 11:08 PM which arrives into Pisa at 3:28 PM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 15h 21m. The schedules shown below are for the next available departures.





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12h 42m • 5 changes
Want to know about travelling from Mainz to Pisa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Pisa. However, there are services departing from Mainz station and arriving at Pisa station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 15h 21m.
Mainz to Pisa train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Hauptbahnhof station.
Mainz to Pisa train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Pisa Centrale station.
Book your Mainz to Pisa train tickets online with Deutsche Bahn Regio (DB Regional), Nederlandse Spoorwegen (NS) and 5 other operators.
The distance between Mainz and Pisa is 716.2 km. The road distance is 1,034 km.
You can take a train from Mainz, Hauptbahnhof to Pisa Centrale via Mannheim, Hauptbahnhof, Basel SBB, Lugano, Milano Centrale, and Firenze S.M.N. in around 13h 21m.