The average train between Pisa and Milan takes 3h 25m and the fastest train takes 3h 16m. There is a train service every few hours from Pisa to Milan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Pisa and Milan. The earliest departure is at 4:15 AM at night, and the last departure from Pisa is at 8:34 PM which arrives into Milan at 11:50 PM. All services require a transfer, and take on average 3h 25m. The schedules shown below are for the next available departures.

4h 35m • 1 change

3h 26m • 1 change

3h 20m • 1 change

3h 18m • 1 change

4h 35m • 1 change

3h 26m • 1 change

3h 20m • 1 change

3h 18m • 1 change

3h 31m • 1 change

3h 26m • 1 change

3h 20m • 1 change

3h 18m • 1 change
Want to know about travelling from Pisa to Milan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Pisa to Milan. However, there are services departing from Pisa station and arriving at Milan station via Firenze S.M.N.. The journey, including transfers, takes approximately 3h 25m.
Pisa to Milan train services, operated by Trenitalia, depart from Pisa Centrale station.
Pisa to Milan train services, operated by Trenitalia, arrive at Milano Centrale station.
Book your Pisa to Milan train tickets online with Trenitalia and Trenitalia Frecce.
The distance between Pisa and Milan is 217.6 km. The road distance is 382 km.
You can take a train from Pisa Centrale to Milano Centrale via Firenze S.M.N. in around 4h 7m.