Mainz to Rome Trains

Trip Overview

The average train between Mainz and Rome takes 15h 10m and the fastest train takes 11h 33m. The train service runs several times per day from Mainz to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

15h 10m
Duration: 1,232 km
Distance: €275
Average price: Every 4 hours
Frequency

Train

best

Take the train from Mainz, Hauptbahnhof to Mannheim, Hauptbahnhoftrain 55 / ...
Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain 12 / ...
Take the train from Basel SBB to Luganotrain Ec
Take the train from Lugano to Milano Centraletrain
Take the train from Milano Centrale to Roma Terminitrain

12h 35m

€149–483

Mainz to Rome train times

Trains run every 4 hours between Mainz and Rome. The earliest departure is at 1:43 AM at night, and the last departure from Mainz is at 11:08 PM which arrives into Rome at 4:19 PM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 15h 10m. The schedules shown below are for the next available departures.

Departing Wednesday, October 28, 2026

4:42 PM → 11:00 AM
Arrives next day
18h 18m • 4 changes
11:08 PM → 4:19 PM
Arrives next day
17h 11m • 4 changes

Departing Thursday, October 29, 2026

1:43 AM → 5:30 PM
15h 47m • 4 changes
7:46 AM → 7:19 PM
11h 33m • 4 changes
9:13 AM → 9:05 PM
11h 52m • 4 changes
11:17 AM → 11:24 PM
12h 7m • 4 changes
Show more

Departing Friday, October 30, 2026

2:01 AM → 5:30 PM
15h 29m • 4 changes
7:46 AM → 7:19 PM
11h 33m • 4 changes
9:13 AM → 9:05 PM
11h 52m • 4 changes
11:17 AM → 11:24 PM
12h 7m • 4 changes
Show more

Departing Saturday, October 31, 2026

5:40 AM → 5:30 PM
11h 50m • 4 changes
9:13 AM → 9:05 PM
11h 52m • 4 changes
11:17 AM → 11:24 PM
12h 7m • 4 changes
1:13 PM → 9:19 AM
Arrives next day
20h 6m • 4 changes
Show more

Departing Sunday, November 1, 2026

5:40 AM → 5:30 PM
11h 50m • 4 changes
9:13 AM → 9:05 PM
11h 52m • 4 changes
11:17 AM → 11:24 PM
12h 7m • 4 changes
1:13 PM → 9:19 AM
Arrives next day
20h 6m • 4 changes
Show more

Departing Monday, November 2, 2026

5:40 AM → 5:30 PM
11h 50m • 4 changes
7:46 AM → 7:19 PM
11h 33m • 4 changes
9:13 AM → 9:05 PM
11h 52m • 4 changes
11:17 AM → 11:24 PM
12h 7m • 4 changes
Show more

Departing Tuesday, November 3, 2026

5:40 AM → 5:30 PM
11h 50m • 4 changes
7:46 AM → 7:19 PM
11h 33m • 4 changes
9:13 AM → 9:05 PM
11h 52m • 4 changes
11:17 AM → 11:24 PM
12h 7m • 4 changes

Frequently asked questions

Want to know about travelling from Mainz to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.