The average train between Mainz and Rome takes 14h 51m and the fastest train takes 11h 33m. The train service runs several times per day from Mainz to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Mainz and Rome. The earliest departure is at 5:40 AM in the morning, and the last departure from Mainz is at 11:08 PM which arrives into Rome at 4:19 PM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 14h 51m. The schedules shown below are for the next available departures.




11h 49m • 4 changes



11h 33m • 4 changes



11h 52m • 4 changes



12h 7m • 4 changes



11h 49m • 4 changes



11h 33m • 4 changes



11h 52m • 4 changes



12h 7m • 4 changes



11h 49m • 4 changes



11h 33m • 4 changes



11h 52m • 4 changes



12h 7m • 4 changes



11h 49m • 4 changes



11h 33m • 4 changes



11h 52m • 4 changes



12h 7m • 4 changesWant to know about travelling from Mainz to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Rome. However, there are services departing from Mainz station and arriving at Rome station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 14h 51m.
Mainz to Rome train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Hauptbahnhof station.
Mainz to Rome train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Roma Termini station.
Book your Mainz to Rome train tickets online with Deutsche Bahn Regio (DB Regional), Nederlandse Spoorwegen (NS) and 4 other operators.
The distance between Mainz and Rome is 955.8 km. The road distance is 1,232 km.
You can take a train from Mainz, Hauptbahnhof to Roma Termini via Mannheim, Hauptbahnhof, Basel SBB, Lugano, and Milano Centrale in around 12h 36m.