The average train between Mainz and Rome takes 15h 4m and the fastest train takes 12h 8m. The train service runs several times per day from Mainz to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mainz and Rome. The earliest departure is at 1:42 AM at night, and the last departure from Mainz is at 11:12 PM which arrives into Rome at 3:19 PM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 15h 4m. The schedules shown below are for the next available departures.
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20h 22m • 4 changes
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18h 3m • 4 changes
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16h 3m • 4 changes
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16h 7m • 4 changes




12h 12m • 4 changes




12h 19m • 4 changes




12h 8m • 4 changes
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20h 22m • 4 changes




12h 12m • 4 changes




12h 19m • 4 changes




12h 8m • 4 changes
Arrives next day




20h 22m • 4 changes




13h 37m • 4 changes




12h 19m • 4 changes




12h 8m • 4 changes




12h 27m • 4 changes




12h 12m • 4 changes




12h 19m • 4 changes




12h 8m • 4 changes




12h 27m • 4 changes




13h 37m • 4 changes




12h 19m • 4 changes




12h 8m • 4 changes




12h 27m • 4 changes
Want to know about travelling from Mainz to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Rome. However, there are services departing from Mainz station and arriving at Rome station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 15h 4m.
Mainz to Rome train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Römisches Theater station.
Mainz to Rome train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Roma Termini station.
Book your Mainz to Rome train tickets online with Deutsche Bahn Regio (DB Regional), Deutsche Bahn Intercity (DB IC) and 4 other operators.
The distance between Mainz and Rome is 955.8 km. The road distance is 1,231 km.
You can take a train from Mainz, Römisches Theater to Roma Termini via Mannheim, Hauptbahnhof, Basel SBB, Lugano, and Milano Centrale in around 13h 18m.