The average train between Mainz and Palermo takes 30h 57m and the fastest train takes 29h 41m. The train service runs several times per day from Mainz to Palermo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Mainz and Palermo. The earliest departure is at 11:17 AM in the morning, and the last departure from Mainz is at 5:17 PM which arrives into Palermo at 10:58 PM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 30h 57m. The schedules shown below are for the next available departures.
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31h 47m • 5 changes
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30h 5m • 5 changes
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31h 47m • 5 changes
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29h 41m • 5 changes
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31h 47m • 5 changes
Arrives next day





29h 41m • 5 changes
Arrives next day





31h 47m • 5 changes
Arrives next day





30h 5m • 5 changes
Want to know about travelling from Mainz to Palermo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Palermo. However, there are services departing from Mainz station and arriving at Palermo station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 30h 57m.
Mainz to Palermo train services, operated by Süwex, depart from Mainz, Hauptbahnhof station.
Mainz to Palermo train services, operated by Süwex, arrive at Palermo Centrale station.
Book your Mainz to Palermo train tickets online with Süwex, Deutsche Bahn Intercity (DB IC) and 4 other operators.
The distance between Mainz and Palermo is 1,377.6 km. The road distance is 2,098 km.
You can take a train from Mainz, Hauptbahnhof to Palermo Centrale via Mannheim, Hauptbahnhof, Basel SBB, Lugano, Milano Centrale, and Roma Termini in around 25h 5m.