Rome2Rio

Mainz to Palermo buses

Find Transport to Palermo

View schedule
QR code to download the Rome2Rio app

Download the Rome2Rio travel app

Scan QR code with your phone to download the app

Download on the App StoreGet it on Google Play

Trip Overview

The bus between Mainz and Palermo takes 2d 3h. The bus runs, on average, 4 times per week from Mainz to Palermo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 3h
Duration
3,862 km
Distance
€313
Average price
4 times a week
Frequency

Mainz to Palermo bus times

Buses run 4 times a week between Mainz and Palermo. The service departs Mainz at 6:10 AM in the morning, which arrives into Palermo at 11:00:00. All services require a transfer at Frankfurt(Main)Hbf and take an average of 2d 3h. The schedules shown below are for the next available departures.

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    FlixBusFlixBus2d 3h • 1 change

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    FlixBusFlixBus2d 3h • 1 change

Departing Sunday, November 15, 2026

  •  → 

    Arrives +2 days

    FlixBusFlixBus2d 3h • 1 change

Departing Monday, November 16, 2026

  •  → 

    Arrives +2 days

    FlixBusFlixBus2d 3h • 1 change

Frequently asked questions

Want to know about travelling from Mainz to Palermo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mainz to Palermo.ExpandLaunch map view
  • Distance: 3,861.8 km
  • Duration: 2d 3h

What companies run services between Mainz, Germany and Palermo, Italy?

Onebus operates a bus from Mühlheim am Main to Palermo Piazza Cairoli once a week. Tickets cost €250–350 and the journey takes 28h 19m.

Operators