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Prague to Palermo trains

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Trip Overview

The average train between Prague and Palermo takes 42h 55m and the fastest train takes 36h 37m. There is at least one train per day from Prague to Palermo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

42h 55m
Duration
2,205 km
Distance
€339
Average price
Once daily
Frequency

Prague to Palermo train times

Trains run once daily between Prague and Palermo. The earliest departure is at 6:21 AM in the morning, and the last departure from Prague is at 2:21 PM which arrives into Palermo at 7:13 PM. All services require a transfer at Linz/Donau Hbf and take an average of 42h 55m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

  •  → 

    Arrives next day

    ÖBB EuroCityRailjetÖBBTrenitalia FrecceTrenitalia Intercity40h 37m • 4 changes

Departing Wednesday, November 11, 2026

  •  → 

    Arrives next day

    ÖBB EuroCityRailjetÖBBTrenitalia FrecceTrenitalia Intercity40h 37m • 4 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    ÖBB EuroCityRailjetÖBBTrenitalia FrecceTrenitalia Intercity36h 37m • 4 changes
  •  → 

    Arrives +2 days

    ÖBB EuroCityRailjetÖBBTrenitalia FrecceTrenitalia Intercity2d 4h • 4 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    ÖBB EuroCityRailjetÖBBTrenitalia FrecceTrenitalia Intercity36h 37m • 4 changes
  •  → 

    Arrives +2 days

    ÖBB EuroCityRailjetÖBBTrenitalia FrecceTrenitalia Intercity2d 4h • 4 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    ÖBB EuroCityRailjetÖBBTrenitalia FrecceTrenitalia Intercity36h 37m • 4 changes
  •  → 

    Arrives +2 days

    ÖBB EuroCityRailjetÖBBTrenitalia FrecceTrenitalia Intercity2d 4h • 4 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    ÖBB EuroCityRailjetÖBBTrenitalia FrecceTrenitalia Intercity36h 37m • 4 changes

Frequently asked questions

Want to know about travelling from Prague to Palermo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Prague to Palermo.ExpandLaunch map view
  • Distance: 2,205.2 km
  • Duration: 42h 55m

What companies run services between Prague, Czechia and Palermo, Italy?

You can take a train from Praha Hlavni Nadrazi to Palermo Centrale via Linz/Donau Hbf, Innsbruck Hauptbahnhof, Bolzano Bozen, and Roma Termini in around 29h 1m.

Operators