Mainz to Italy trains

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Trip Overview

The average train between Mainz and Italy takes 15h 22m and the fastest train takes 12h 30m. The train service runs several times per day from Mainz to Italy. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

15h 22m
Duration: 1,230 km
Distance: €297
Average price: Every 4 hours
Frequency

Train

best

Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain S5 / ...
Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain 20 / ...
Take the train from Basel SBB to Luganotrain Ec
Take the train from Lugano to Milano Centraletrain
Take the train from Milano Centrale to Roma Terminitrain

13h 18m

€164–631

Mainz to Italy train times

Trains run every 4 hours between Mainz and Italy. The earliest departure is at 1:42 AM at night, and the last departure from Mainz is at 11:12 PM which arrives into Italy at 3:19 PM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 15h 22m. The schedules shown below are for the next available departures.

Departing Tuesday, June 2, 2026

10:26 AM → 11:24 PM
12h 58m • 4 changes
12:26 PM → 9:19 AM
Arrives next day
20h 53m • 4 changes
4:30 PM → 11:00 AM
Arrives next day
18h 30m • 4 changes

Departing Wednesday, June 3, 2026

5:00 AM → 5:30 PM
12h 30m • 4 changes
6:27 AM → 7:19 PM
12h 52m • 4 changes
8:26 AM → 9:05 PM
12h 39m • 4 changes
10:26 AM → 11:24 PM
12h 58m • 4 changes
Show more

Departing Thursday, June 4, 2026

1:42 AM → 5:30 PM
15h 48m • 4 changes
6:27 AM → 7:19 PM
12h 52m • 4 changes
8:26 AM → 9:05 PM
12h 39m • 4 changes
10:26 AM → 11:24 PM
12h 58m • 4 changes
Show more

Departing Friday, June 5, 2026

5:00 AM → 5:30 PM
12h 30m • 4 changes
6:27 AM → 7:19 PM
12h 52m • 4 changes
8:26 AM → 9:05 PM
12h 39m • 4 changes
10:26 AM → 11:24 PM
12h 58m • 4 changes
Show more

Departing Saturday, June 6, 2026

1:42 AM → 3:19 PM
13h 37m • 4 changes
6:27 AM → 7:19 PM
12h 52m • 4 changes
8:26 AM → 9:05 PM
12h 39m • 4 changes
10:26 AM → 11:24 PM
12h 58m • 4 changes
Show more

Departing Sunday, June 7, 2026

1:42 AM → 3:19 PM
13h 37m • 4 changes
6:27 AM → 7:19 PM
12h 52m • 4 changes
8:26 AM → 9:05 PM
12h 39m • 4 changes
10:26 AM → 11:24 PM
12h 58m • 4 changes
Show more

Departing Monday, June 8, 2026

5:00 AM → 5:30 PM
12h 30m • 4 changes
6:27 AM → 7:19 PM
12h 52m • 4 changes
8:26 AM → 9:05 PM
12h 39m • 4 changes
10:26 AM → 11:24 PM
12h 58m • 4 changes

Frequently asked questions

Want to know about travelling from Mainz to Italy? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Launch map view

Distance: 1,230.5 km
Duration: 15h 22m

What companies run services between Mainz, Germany and Italy?

You can take a train from Mainz, Römisches Theater to Roma Termini via Mannheim, Hauptbahnhof, Basel SBB, Lugano, and Milano Centrale in around 13h 18m.

Operators